DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cul4 and Cacul1

DIOPT Version :9

Sequence 1:	NP_001163084.1	Gene:	Cul4 / 35780	FlyBaseID:	FBgn0033260	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_084473.1	Gene:	Cacul1 / 78832	MGIID:	1926082	Length:	377	Species:	Mus musculus

Alignment Length:	331	Identity:	71/331 - (21%)
Similarity:	128/331 - (38%)	Gaps:	86/331 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KKYKPMDTTELHENTENIAACLKKAENVAPTAAAASSVGRSAFAAQNMNSASTNGERLPNFSKLG 69
            |:..||....|.| ...:...||..:       ||::|.::|.|..:.::.:.|
Mouse    79 KEGLPMGPPPLPE-PNGVIMMLKSCD-------AAAAVAKTAPAPTSSSTININ----------- 124

  Fly    70 GSHGEIRTASTTSNLLNRMGAIHNSKPGDVKKIVIKNFKDKPTLPDNYSKDTY-VKLEEAVIAIQ 133
                    .||:..|:|              .|.|:::           |.|| .||:.|:..:.
Mouse   125 --------TSTSKFLMN--------------VITIEDY-----------KSTYWPKLDGAIDQLL 156

  Fly   134 LSKP---IKYSLEELYQAVVNMCSHKMDAQLYAKLKELTEQHVKRNIKLKELTGGSMDKLILLEK 195
            ...|   |..|.|::|..|......:...|:|:.|.:....|::|  ..|||.....|  :.:|:
Mouse   157 TQSPGDYIPISYEQIYSCVYKCVCQQHSEQMYSDLIKKITSHLER--VSKELQASPPD--LYIER 217

  Fly   196 INHWWLSFCQQMIMIRSI---FLYMDRTYVLQNSTVHSIWDMGLDLFRIHFAQNSVVQKRTVDGL 257
            .|   ::..|.|..::||   |:||::.|: :......:.|..:.||..|     |.:|.....:
Mouse   218 FN---IALGQYMGALQSIVPLFIYMNKFYI-ETKLNRDLKDDLIKLFTEH-----VAEKHIYSLM 273

  Fly   258 LTLIEKERQGSTVDRGLLKSLVRMLCDL-----QIYTSSFEEKFL--------DATNQLYKAESQ 309
            ..|:|.:.....|....:.::|:.|..|     |:..:.| .||:        ::....|.|:.|
Mouse   274 PLLLEAQSTPFQVTPSTMANIVKGLYTLRPEWVQMAPTLF-SKFIPNILPPAVESELSEYAAQDQ 337

  Fly   310 RKMQEL 315
            :..:||
Mouse   338 KLQREL 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_001163084.1	Cullin	124..721	CDD:279260	49/211 (23%)
		CULLIN	503..644	CDD:214545
		Cullin_Nedd8	750..815	CDD:214883
Cacul1	NP_084473.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63
		Cullin	146..>264	CDD:279260	32/130 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..377
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900