Protein Alignment Cul4 and cul5

DIOPT Version :10

• Sequence 1: NP_610352.2
• Gene: Cul4 / 35780
• FlyBaseID: FBgn0033260
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: NP_001072836.1
• Gene: cul5 / 780297
• XenbaseID: XB-GENE-484069
• Length: 780
• Species: Xenopus tropicalis
• Alignment Length: 840
• Identity: 219/840 - (26%)
• Similarity: 383/840 - (45%)
• Gaps: 161/840 - (19%)

  Fly    81 TSNLLNRMGAIHNSKPGD-VKKIVIKNFKDKPTLPDNYSKDTYVKLEEAVIAIQL---SKPIKYS 141
            |||||...|::......| ::.||:|..:.     ::.:|..:..|...|.|:.|   ..|.|..
 Frog     3 TSNLLKNKGSLQFEDKWDFMRPIVLKLLRQ-----ESVTKQQWFDLFSDVHAVCLWDDKGPAKIH 62

  Fly   142 -------LEELYQAVVNMCSHKMDAQLYAKLKELTEQHVKRNIKLKELTGGSMDKLILLEKINHW 199
                   |:.:.||...:.||:.|..|.                          |..::|
 Frog    63 QALKEDILDFIKQAQARVLSHQDDTALL--------------------------KAYIVE----- 96

  Fly   200 WLSFCQQMIMIRSIFLYMDRTYV----------LQNSTVHSIWDMGLDLFRIHFAQNSVVQKRTV 254
            |..|..|..::...|..::.|.:          :::|.|..:.   ||.:......|  ::.|..
 Frog    97 WRKFFTQCDILPKPFCQLEITLMGKQGSNKKSNVEDSIVRKLM---LDTWNESIFSN--IKNRLQ 156

  Fly   255 DGLLTLIEKERQGSTVDR----GLLKSLVRMLCD-----LQIYTSSFEEKFLDATNQLYKAESQR 310
            |..:.|:..||.|...|.    |:.:|.|. ||.     ||||..:||:.:||:|.:.|:.::..
 Frog   157 DSAMKLVHAERLGEAFDSQLVIGVRESYVN-LCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPS 220

  Fly   311 KMQELEVPEYLQHVNKRLAEENERLRHYLDSSTK------------HPLIYNVEKELLAEHLTSI 363
            .:|:..|..|:::.:.:|.||..|...||::..:            :.|:.:.::.:|||
 Frog   221 YLQQNGVQNYMKYADAKLKEEENRALRYLETRRECNSVQALMECCVNALVTSFKETILAE----- 280

  Fly   364 LQKGLDSLLEDNRLSDLTLLYGLLSRVKNGTSELCGNFNGFIKKKG--------RTIVIDPEKDK 420
                ...:::.|....|.|::.|:.:|.||...:..:....|...|        .||..|.||
 Frog   281 ----CQGMIKRNETEKLHLMFSLMDKVPNGIEPMLKDLEEHIVSAGLADMVAAAETITTDSEK-- 339

  Fly   421 SMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFIN--------------------QRANK 465
             .|:.||...::...:|:..|:.:.:|..:..:|::..:|                    |..:|
 Frog   340 -YVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESK 403

  Fly   466 PAELIAKYVDMKLRSG--NKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSA 528
            ..||:|.|.||.||..  :|..|.||:|..|.:::::.:::..||||..::|..|.:||::..||
 Frog   404 CPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISA 468

  Fly   529 SVDSEKSMLSKLKQECG--GGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVSILT 591
            ..:.|::|:..|: |.|  ..:.:||..||:|:::|.|:|.||:....:|...:....:.:.||.
 Frog   469 DSEIEENMVEWLR-EVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILN 532

  Fly   592 MGYWPTYA-------PTEVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGPK 649
            .|.|...:       |||:    :.:.|:  ..:||.:.||||||.|...:.|.::..:.:.|..
 Frog   533 AGAWSRSSEKVFVSLPTEL----EDLIPE--VEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQY 591

  Fly   650 ELLVSLFQALVLLLFNDKP--VLSYEEILAATLIEDGELRRTLQSLACG---RARVITKTP---K 706
            :|.|:.||..||..:|.:|  .:|:|.:..||.:.|.||||||.||...   :.:|::..|   .
 Frog   592 DLEVTTFQLAVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLSYEPTVNS 656

  Fly   707 GREILDGDQFDFNNEFT----NKL-FRIKINQI-QMKETNEEQKATE-ERVFQDRQYQIDAAIVR 764
            .::..:|..|..|.||:    .|: .|.|||.| :::.|.|..:..| |.:.|.|..:...||::
 Frog   657 PKDFTEGTLFSVNQEFSLIKNGKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQ 721

  Fly   765 IMKMRKTLSHNLLITEL---FNQLTFPVKPADLKKRIESLIDRDYMERDKDNQNQYNYVA 821
            ||||||.:::..|.|||   ...:..|.|.. :|::||.||:..|::||:.:.|.:.|:|
 Frog   722 IMKMRKKITNAQLQTELVEILKNMFLPQKKM-IKEQIEWLIEHKYIKRDESDINTFIYMA 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_610352.2	Cullin	124..722	CDD:459983	169/685 (25%)
		Cullin_Nedd8	753..813	CDD:463146	23/62 (37%)
cul5	NP_001072836.1	Cullin	19..672	CDD:459983	174/713 (24%)
		Cullin_Nedd8	711..772	CDD:463146	23/61 (38%)