DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul4 and Cul5

DIOPT Version :9

Sequence 1:	NP_001163084.1	Gene:	Cul4 / 35780	FlyBaseID:	FBgn0033260	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_082083.3	Gene:	Cul5 / 75717	MGIID:	1922967	Length:	780	Species:	Mus musculus

Alignment Length:	842	Identity:	219/842 - (26%)
Similarity:	383/842 - (45%)	Gaps:	165/842 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 TSNLLNRMGAIHNSKPGD-VKKIVIKNFKDKPTLPDNYSKDTYVKLEEAVIAIQL-----SKPIK 139
            |||||...|::......| :..||:|..:.     ::.:|..:..|...|.|:.|     |..|.
Mouse     3 TSNLLKNKGSLQFEDKWDFMHPIVLKLLRQ-----ESVTKQQWFDLFSDVHAVCLWDDKGSSKIH 62

  Fly   140 YSLEE-----LYQAVVNMCSHKMDAQLYAKLKELTEQHVKRNIKLKELTGGSMDKLILLEKINHW 199
            .:|:|     :.||...:.||:.|..|.                          |..::|
Mouse    63 QALKEDILEFIKQAQARVLSHQDDTALL--------------------------KAYIVE----- 96

  Fly   200 WLSFCQQMIMIRSIFLYMDRTYV----------LQNSTVHSIWDMGLDLFRIHFAQNSVVQKRTV 254
            |..|..|..::...|..::.|.:          :::|.|..:.   ||.:......|  ::.|..
Mouse    97 WRKFFTQCDILPKPFCQLEVTLLGKQSSNKKSNMEDSIVRKLM---LDTWNESIFSN--IKNRLQ 156

  Fly   255 DGLLTLIEKERQGSTVDR----GLLKSLVRMLCD-----LQIYTSSFEEKFLDATNQLYKAESQR 310
            |..:.|:..||.|...|.    |:.:|.|. ||.     ||||..:||:.:||:|.:.|:.::..
Mouse   157 DSAMKLVHAERLGEAFDSQLVIGVRESYVN-LCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPS 220

  Fly   311 KMQELEVPEYLQHVNKRLAEENERLRHYLDSSTK------------HPLIYNVEKELLAEHLTSI 363
            .:|:..|..|:::.:.:|.||.:|...||::..:            :.|:.:.::.:|||
Mouse   221 YLQQNGVQNYMKYADAKLKEEEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAE----- 280

  Fly   364 LQKGLDSLLEDNRLSDLTLLYGLLSRVKNGTSELCGNFNGFIKKKG--------RTIVIDPEKDK 420
                ...:::.|....|.|::.|:.:|.||...:..:....|...|        .||..|.||
Mouse   281 ----CQGMIKRNETEKLHLMFSLMDKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEK-- 339

  Fly   421 SMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFIN--------------------QRANK 465
             .|:.||...::...:|:..|:.:.:|..:..:|::..:|                    |..:|
Mouse   340 -YVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESK 403

  Fly   466 PAELIAKYVDMKLRSG--NKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSA 528
            ..||:|.|.||.||..  :|..|.||:|..|.:::::.:::..||||..::|..|.:||::..||
Mouse   404 CPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISA 468

  Fly   529 SVDSEKSMLSKLKQECG--GGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVSILT 591
            ..:.|::|:..|: |.|  ..:.:||..||:|:::|.|:|.||:....:|...:....:.:.||.
Mouse   469 DSEIEENMVEWLR-EVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILN 532

  Fly   592 MGYWPTYA-------PTEVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGPK 649
            .|.|...:       |||:    :.:.|:  ..:||.:.||||||.|...:.|.::..:.:.|..
Mouse   533 AGAWSRSSEKVFVSLPTEL----EDLIPE--VEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQY 591

  Fly   650 ELLVSLFQALVLLLFNDKP--VLSYEEILAATLIEDGELRRTLQSLACG---RARVITKTPK--- 706
            :|.|:.||..||..:|.:|  .:|:|.:..||.:.|.||||||.||...   :.:|:...|:
Mouse   592 DLEVTTFQLAVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYDPQVNS 656

  Fly   707 GREILDGDQFDFNNEFT-------NKLFRIKINQI-QMKETNEEQKATE-ERVFQDRQYQIDAAI 762
            .::..:|..|..|.:|:       .|  |.|||.| :::.|.|..:..| |.:.|.|..:...||
Mouse   657 PKDFTEGTLFSVNQDFSLIKNAKVQK--RGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAI 719

  Fly   763 VRIMKMRKTLSHNLLITEL---FNQLTFPVKPADLKKRIESLIDRDYMERDKDNQNQYNYVA 821
            ::||||||.:|:..|.|||   ...:..|.|.. :|:::|.||:..|:.||:.:.|.:.|:|
Mouse   720 IQIMKMRKKISNAQLQTELVEILKNMFLPQKKM-IKEQMEWLIEHRYIRRDEADINTFIYMA 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_001163084.1	Cullin	124..721	CDD:279260	170/684 (25%)
		CULLIN	503..644	CDD:214545	44/149 (30%)
		Cullin_Nedd8	750..815	CDD:214883	24/67 (36%)
Cul5	NP_082083.3	Cullin	19..672	CDD:334305	175/713 (25%)
Cul5	NP_082083.3	Cullin_Nedd8	713..772	CDD:337788	22/59 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820