DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cul4 and Cul4b

DIOPT Version :9

Sequence 1:NP_001163084.1 Gene:Cul4 / 35780 FlyBaseID:FBgn0033260 Length:821 Species:Drosophila melanogaster
Sequence 2:NP_001103612.1 Gene:Cul4b / 72584 MGIID:1919834 Length:970 Species:Mus musculus


Alignment Length:817 Identity:509/817 - (62%)
Similarity:624/817 - (76%) Gaps:17/817 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 KKYKPMDTTELHENTENIAACLKKAENVAPTAAAASSVGRSAFAAQNMNSASTNGERLPNFSKLG 69
            ||.:..||.|.      :....|.||.   :::::||...:|..:|....     ::|...|.|.
Mouse   171 KKLRFEDTLEF------VGIDTKMAEE---SSSSSSSSSPTAATSQQQQQ-----QQLKTKSILI 221

  Fly    70 GSHGEIRTASTTSNLLNRMGAIHNSKPGDVKKIVIKNFKDKPTLPDNYSKDTYVKLEEAVIAIQL 134
            .|...:..|:..:.....:.:..|||||..||:|||||||||.||:||:.:|:.||:|||.|||.
Mouse   222 SSVASVHHANGLAKSSTAVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQN 286

  Fly   135 SKPIKYSLEELYQAVVNMCSHKMDAQLYAKLKELTEQHVKRNIKLKELTGGSMDKLILLEKINHW 199
            |..|||:||||||||.|:||||:.|.||.:|:::.|.|:|..|  .:....|:|.::.|:||:..
Mouse   287 STSIKYNLEELYQAVENLCSHKISANLYKQLRQICEDHIKAQI--HQFREDSLDSVLFLKKIDRC 349

  Fly   200 WLSFCQQMIMIRSIFLYMDRTYVLQNSTVHSIWDMGLDLFRIHFAQNSVVQKRTVDGLLTLIEKE 264
            |.:.|:||||||||||::|||||||||.:.|||||||:|||.|...:..||.:|:||:|.|||:|
Mouse   350 WQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERE 414

  Fly   265 RQGSTVDRGLLKSLVRMLCDLQIYTSSFEEKFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLA 329
            |.|..:||.||:||:.||.|||||..|||::||..||:||.||.|:.|||.||||||.||||||.
Mouse   415 RNGEAIDRSLLRSLLSMLSDLQIYQDSFEQQFLQETNRLYAAEGQKLMQEREVPEYLHHVNKRLE 479

  Fly   330 EENERLRHYLDSSTKHPLIYNVEKELLAEHLTSILQKGLDSLLEDNRLSDLTLLYGLLSRVKNGT 394
            ||.:||..|||.:|:..||.:|||:||.||||:||||||:|||::||:.||:|||.|.|||:.|.
Mouse   480 EEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGV 544

  Fly   395 SELCGNFNGFIKKKGRTIVIDPEKDKSMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFI 459
            ..|...:..:||..|.||||:|||||:|||:|||||||:|.|:.|||..||||.|:::||||.||
Mouse   545 QVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFI 609

  Fly   460 NQRANKPAELIAKYVDMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLV 524
            |:|.||||||||||||.|||:|||..|||||||.|||||::||||:|||||||||||||||||||
Mouse   610 NKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLV 674

  Fly   525 GKSASVDSEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVSI 589
            |||||||:|||||||||.|||..|||||||||||||||:||.|.|:.: :.|.....|::|.|:|
Mouse   675 GKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQY-MQNQNVPGNIELTVNI 738

  Fly   590 LTMGYWPTYAPTEVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGPKELLVS 654
            |||||||||.|.||.:||:.:..|:||..|||.||||||||||.|||:|:|:|:|..|.|||.||
Mouse   739 LTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVS 803

  Fly   655 LFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACGRARVITKTPKGREILDGDQFDFN 719
            |||.:|||:||:....|.|||..||.||||||||||||||||:|||:.|.|||::|.|||:|..|
Mouse   804 LFQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICN 868

  Fly   720 NEFTNKLFRIKINQIQMKETNEEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITELFNQ 784
            ::|.:|||||||||||||||.|||.:|.||||||||||||||||||||||||||||||::|::||
Mouse   869 DDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQ 933

  Fly   785 LTFPVKPADLKKRIESLIDRDYMERDKDNQNQYNYVA 821
            |.|||||||||||||||||||||||||:|.|||||:|
Mouse   934 LKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA 970

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cul4NP_001163084.1 Cullin 124..721 CDD:279260 385/596 (65%)
CULLIN 503..644 CDD:214545 100/140 (71%)
Cullin_Nedd8 750..815 CDD:214883 58/64 (91%)
Cul4bNP_001103612.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..157
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q13620 112..115
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 189..211 6/24 (25%)
Cullin 275..870 CDD:279260 385/597 (64%)
CULLIN 653..793 CDD:214545 100/140 (71%)
Cullin_Nedd8 899..964 CDD:214883 58/64 (91%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 759 1.000 Domainoid score I85
eggNOG 1 0.900 - - E1_COG5647
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2660
Inparanoid 1 1.050 977 1.000 Inparanoid score I316
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53685
OrthoDB 1 1.010 - - D1040292at2759
OrthoFinder 1 1.000 - - FOG0000491
OrthoInspector 1 1.000 - - otm44086
orthoMCL 1 0.900 - - OOG6_101788
Panther 1 1.100 - - O PTHR11932
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R16814
SonicParanoid 1 1.000 - - X1830
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.870

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