Protein Alignment Cul4 and Cul5

DIOPT Version :10

• Sequence 1: NP_610352.2
• Gene: Cul4 / 35780
• FlyBaseID: FBgn0033260
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: XP_006243152.1
• Gene: Cul5 / 64624
• RGDID: 621742
• Length: 828
• Species: Rattus norvegicus
• Alignment Length: 830
• Identity: 215/830 - (25%)
• Similarity: 372/830 - (44%)
• Gaps: 168/830 - (20%)

  Fly    81 TSNLLNRMGAIHNSKPGD-VKKIVIKNFKDKPTLPDNYSKDTYVKLEEAVIAIQL-----SKPIK 139
            |||||...|::......| ::.||:|..:.     ::.:|..:..|...|.|:.|     |..|.
  Rat    78 TSNLLKNKGSLQFEDKWDFMRPIVLKLLRQ-----ESVTKQQWFDLFSDVHAVCLWDDKGSSKIH 137

  Fly   140 YSLEE-----LYQAVVNMCSHKMDAQLYAKLKELTEQHVKRNIKLKELTGGSMDKLILLEKINHW 199
            .:|:|     :.||...:.||:.|..|.                          |..::|
  Rat   138 QALKEDILEFIKQAQARVLSHQDDTALL--------------------------KAYIVE----- 171

  Fly   200 WLSFCQQMIMIRSIFLYMDRTYV----------LQNSTVHSIWDMGLDLFRIHFAQNSVVQKRTV 254
            |..|..|..::...|..::.|.:          :::|.|..:.   ||.:......|  ::.|..
  Rat   172 WRKFFTQCDILPKPFCQLEVTLLGKQSSNKKSNMEDSIVRKLM---LDTWNESIFSN--IKNRLQ 231

  Fly   255 DGLLTLIEKERQGSTVDR----GLLKSLVRMLCD-----LQIYTSSFEEKFLDATNQLYKAESQR 310
            |..:.|:..||.|...|.    |:.:|.|. ||.     ||||..:||:.:||:|.:.|:.::..
  Rat   232 DSAMKLVHAERLGEAFDSQLVIGVRESYVN-LCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPS 295

  Fly   311 KMQELEVPEYLQHVNKRLAEENERLRHYLDSSTKHPLIYNVEKELLAEHLTSILQKGLDSLLEDN 375
            .:|:..|..|::               ||.....:.|:.:.::.:|||         ...:::.|
  Rat   296 YLQQNGVQNYMK---------------YLMECCVNALVTSFKETILAE---------CQGMIKRN 336

  Fly   376 RLSDLTLLYGLLSRVKNGTSELCGNFNGFIKKKG--------RTIVIDPEKDKSMVQDLLDFKDK 432
            ....|.|::.|:.:|..|...:..:....|...|        .||..|.||   .|:.||...::
  Rat   337 ETEKLHLMFSLMDKVPGGIEPMLKDLEEHIISAGLADMVAAAETITTDSEK---YVEQLLTLFNR 398

  Fly   433 MDVIVRTCFEHNEKFTNSLREAFEFFIN--------------------QRANKPAELIAKYVDMK 477
            ...:|:..|:.:.:|..:..:|::..:|                    |..:|..||:|.|.||.
  Rat   399 FSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDML 463

  Fly   478 LRSG--NKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDSEKSMLSKL 540
            ||..  :|..|.||:|..|.:::::.:::..||||..::|..|.:||::..||..:.|::|:..|
  Rat   464 LRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWL 528

  Fly   541 KQECG--GGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVSILTMGYWPTYA---- 599
            : |.|  ..:.:||..||:|:::|.|:|.||:....:|...:....:.:.||..|.|...:
  Rat   529 R-EVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVF 592

  Fly   600 ---PTEVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGPKELLVSLFQALVL 661
               |||:    :.:.|:  ..:||.:.||||||.|...:.|.::..:.:.|..:|.|:.||..||
  Rat   593 VSLPTEL----EDLIPE--VEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVL 651

  Fly   662 LLFNDKP--VLSYEEILAATLIEDGELRRTLQSLACG---RARVITKTPK---GREILDGDQFDF 718
            ..:|.:|  .:|:|.:..||.:.|.||||||.||...   :.:|:...|:   .::..:|..|..
  Rat   652 FAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYDPQVNSPKDFTEGTLFSV 716

  Fly   719 NNEFT-------NKLFRIKINQI-QMKETNEEQKATE-ERVFQDRQYQIDAAIVRIMKMRKTLSH 774
            |.:|:       .|  |.|||.| :::.|.|..:..| |.:.|.|..:...||::||||||.:|:
  Rat   717 NQDFSLIKNAKVQK--RGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISN 779

  Fly   775 NLLITEL---FNQLTFPVKPADLKKRIESLIDRDYMERDKDNQNQYNYVA 821
            ..|.|||   ...:..|.|.. :|::||.||:..|:.||:.:.|.:.|:|
  Rat   780 AQLQTELVEILKNMFLPQKKM-IKEQIEWLIEHKYIRRDEADINTFIYMA 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_610352.2	Cullin	124..722	CDD:459983	165/673 (25%)
		Cullin_Nedd8	753..813	CDD:463146	24/62 (39%)
Cul5	XP_006243152.1	Cullin	94..720	CDD:459983	170/701 (24%)
		Cullin_Nedd8	759..820	CDD:463146	24/61 (39%)