DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul4 and cul3b

DIOPT Version :9

Sequence 1:	NP_001163084.1	Gene:	Cul4 / 35780	FlyBaseID:	FBgn0033260	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_001177414.1	Gene:	cul3b / 572370	ZFINID:	ZDB-GENE-081007-1	Length:	766	Species:	Danio rerio

Alignment Length:	773	Identity:	293/773 - (37%)
Similarity:	446/773 - (57%)	Gaps:	53/773 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 NSKPGDVKKIVIKNFKDKP-TLPDNYSKDTYVKLEEAVIAIQLSKPIKYSLEELYQAVVNMCSHK 156
            |...|..||......:..| |:.:.|..:.:..|:.|:..||.......|.||||:....|..||
Zfish     3 NLSKGGTKKDTKMRIRAFPMTMDEKYVNNIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHK 67

  Fly   157 MDAQLYAKLKELTEQHVKRNIK---LKELTGGSMDKLILLEKINHWWLSFCQQMIMIRSIFLYMD 218
            ...:||..|:|:..:|:...::   |..|...      .|:.:|..|......|:|||.|.:|||
Zfish    68 HGEKLYTGLREVVTEHLINKVREDVLNSLNNN------FLQTLNQAWNDHQTAMVMIRDILMYMD 126

  Fly   219 RTYVLQNSTVHSIWDMGLDLFRIHFAQNSVVQKRTVDGLLTLIEKERQGSTVDRGLLKSLVRMLC 283
            |.||.||: |.:::::||.:||....:...::......||.:|.:||:|..||||.:::..:||.
Zfish   127 RVYVQQNN-VENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLM 190

  Fly   284 DL-----QIYTSSFEEKFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENERLRHYLDSST 343
            .|     .:|...||..||:.:.:.::.|||:.:.|.....|::.|..|:.||.||:.|.||.||
Zfish   191 ILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVIHCLDKST 255

  Fly   344 KHPLIYNVEKELLAEHLTSILQ---KGLDSLLEDNRLSDLTLLYGLLSRVKNGTSELCGNFNGFI 405
            :.|::..||:||:::|:.:|::   .||..:|::.:..||..:|.|.|||.||...:|...:.::
Zfish   256 EEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSSYL 320

  Fly   406 KKKGRTIVIDPEKDKS---MVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFINQRANKPA 467
            :::|:.:|.:..:.|:   .:|.|||.|.:.|..::..|.::..|..::...||:|:|..:..|
Zfish   321 REQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSP- 384

  Fly   468 ELIAKYVDMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDS 532
            |.::.::|.||:.|.||.|::|:|..|||.||||||:..|||||.:||:.||:|||..||.|.||
Zfish   385 EYLSLFIDDKLKKGVKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDS 449

  Fly   533 EKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVSILTMGYWPT 597
            ||:|:||||.|||..|||||||||:||.:|......||.|..|....:..:||.|.:||.|||||
Zfish   450 EKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLTSTGVSLGGVDLIVRVLTTGYWPT 514

  Fly   598 YAPT-EVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGP--KE--------- 650
            .:.| :..:||...:..::|.:|||.|||||:|..|..:|:..|.|.| .||  ||
Zfish   515 QSATPKCNIPPSPRHAFEVFRRFYLAKHSGRQLTLQHHMGSADLNATF-YGPIKKEDGSDMVGGA 578

  Fly   651 -----------LLVSLFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACGR--ARVIT 702
                       |.||.||..:|:|||::...::|||...|.|.:.||.|.|||||||:  .||:|
Zfish   579 QVTGSNTRKHILQVSTFQMTILMLFNNREKSTFEEIQQETDIPERELVRALQSLACGKPTQRVLT 643

  Fly   703 KTPKGREILDGDQFDFNNEFTNKLFRIKINQIQMK--ETNEEQKATEERVFQDRQYQIDAAIVRI 765
            |.||.:||.:|..|..|::||::|.|:||..:..|  |::.|:|.|.::|..||:::|:||||||
Zfish   644 KEPKSKEIENGHVFTVNDQFTSRLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRI 708

  Fly   766 MKMRKTLSHNLLITELFNQL--TFPVKPADLKKRIESLIDRDYMERDKDNQNQYNYVA 821
            ||.||.:.||:|:.|:..||  .|...|..:|||||.||:|:|:.|..:::..|.|||
Zfish   709 MKSRKKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_001163084.1	Cullin	124..721	CDD:279260	239/635 (38%)
		CULLIN	503..644	CDD:214545	71/141 (50%)
		Cullin_Nedd8	750..815	CDD:214883	32/66 (48%)
cul3b	NP_001177414.1	Cullin	34..662	CDD:279260	239/636 (38%)
		CULLIN	420..562	CDD:214545	71/141 (50%)
		Cullin_Nedd8	698..758	CDD:287520	29/59 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.930