DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul4 and cul3

DIOPT Version :9

Sequence 1:	NP_001163084.1	Gene:	Cul4 / 35780	FlyBaseID:	FBgn0033260	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_001015975.2	Gene:	cul3 / 548729	XenbaseID:	XB-GENE-974982	Length:	768	Species:	Xenopus tropicalis

Alignment Length:	754	Identity:	289/754 - (38%)
Similarity:	438/754 - (58%)	Gaps:	53/754 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 TLPDNYSKDTYVKLEEAVIAIQLSKPIKYSLEELYQAVVNMCSHKMDAQLYAKLKELTEQHVKRN 176
            |:.:.|....:..|:.|:..||.......|.||||:....|..||...:||..|:|:..:|:...
Frog    24 TMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINK 88

  Fly   177 IK---LKELTGGSMDKLILLEKINHWWLSFCQQMIMIRSIFLYMDRTYVLQNSTVHSIWDMGLDL 238
            ::   |..|...      .|:.:|..|......|:|||.|.:||||.||.||: |.:::::||.:
Frog    89 VREDVLNSLNNN------FLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNN-VENVYNLGLII 146

  Fly   239 FRIHFAQNSVVQKRTVDGLLTLIEKERQGSTVDRGLLKSLVRMLCDL-----QIYTSSFEEKFLD 298
            ||....:...::......||.:|.:||:|..||||.:::..:||..|     .:|...||..||:
Frog   147 FRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLE 211

  Fly   299 ATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENERLRHYLDSSTKHPLIYNVEKELLAEHLTSI 363
            .:.:.::.|||:.:.|.....|::.|..|:.||.||:.|.||.||:.|::..||:||:::|:.:|
Frog   212 MSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTI 276

  Fly   364 LQ---KGLDSLLEDNRLSDLTLLYGLLSRVKNGTSELCGNFNGFIKKKGRTIVIDPEKDKS---M 422
            ::   .||..:|::.:..||..:|.|.|||.||...:|...:.:::::|:.:|.:..:.|:   .
Frog   277 VEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSLYLREQGKALVSEEGEGKNPVDY 341

  Fly   423 VQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFINQRANKPAELIAKYVDMKLRSGNKGTTD 487
            :|.|||.|.:.|..::..|.::..|..::...||:|:|..:..| |.::.::|.||:.|.||.|:
Frog   342 IQGLLDLKSRFDRFLQESFSNDRLFKQTIAGDFEYFLNLNSRSP-EYLSLFIDDKLKKGVKGLTE 405

  Fly   488 EELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDSEKSMLSKLKQECGGGFTSKL 552
            :|:|..|||.||||||:..|||||.:||:.||:|||..||.|.||||:|:||||.|||..|||||
Frog   406 QEVESILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKL 470

  Fly   553 EGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVSILTMGYWPTYAPT-EVTMPPQFINPQQIF 616
            ||||:||.:|......||.|..:....:..:||.|.:||.|||||.:.| :..:||...:..:||
Frog   471 EGMFRDMSISNTTMDEFRQHLQTTGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIF 535

  Fly   617 NKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGP--KE---------------------LLVSLFQA 658
            .:|||.|||||:|..|..:|:..|.|.| .||  ||                     |.||.||.
Frog   536 RRFYLAKHSGRQLTLQHHMGSADLNATF-YGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQM 599

  Fly   659 LVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACGR--ARVITKTPKGREILDGDQFDFNNE 721
            .:|:|||::...::|||...|.|.:.||.|.|||||||:  .||:||.||.:||..|..|..|::
Frog   600 TILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESGHMFTVNDQ 664

  Fly   722 FTNKLFRIKINQIQMK--ETNEEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITELFNQ 784
            ||:||.|:||..:..|  |::.|:|.|.::|..||:::|:||||||||.||.:.||:|:.|:..|
Frog   665 FTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQ 729

  Fly   785 L--TFPVKPADLKKRIESLIDRDYMERDKDNQNQYNYVA 821
            |  .|...|..:|||||.||:|:|:.|..:::..|.|||
Frog   730 LKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_001163084.1	Cullin	124..721	CDD:279260	239/636 (38%)
		CULLIN	503..644	CDD:214545	71/141 (50%)
		Cullin_Nedd8	750..815	CDD:214883	32/66 (48%)
cul3	NP_001015975.2	Cullin	34..665	CDD:366357	239/639 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	677..698		6/20 (30%)
		Cullin_Nedd8	695..762	CDD:214883	32/66 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930