DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul4 and cul4a

DIOPT Version :9

Sequence 1:	NP_001163084.1	Gene:	Cul4 / 35780	FlyBaseID:	FBgn0033260	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_001015893.1	Gene:	cul4a / 548647	XenbaseID:	XB-GENE-1014775	Length:	753	Species:	Xenopus tropicalis

Alignment Length:	762	Identity:	483/762 - (63%)
Similarity:	588/762 - (77%)	Gaps:	14/762 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 ERLPNFSKLGGSHGEIRTASTTSNLLNRMGAIHNSKPGDVKKIVIKNFKDKPTLPDNYSKDTYVK 124
            ::..|||.|.|.          :|.|.:..|: .|||...||::||||||||.|||:|::||:.|
Frog     6 QKKANFSTLAGH----------TNGLTKSSAL-TSKPSASKKLIIKNFKDKPKLPDSYTQDTWQK 59

  Fly   125 LEEAVIAIQLSKPIKYSLEELYQAVVNMCSHKMDAQLYAKLKELTEQHVKRNIKLKELTGGSMDK 189
            |:|||.||:.|..|||:||||||||.|:||:|:...||.:|:::.|:|:|..|  .:....|:|.
Frog    60 LQEAVNAIESSTSIKYNLEELYQAVENLCSYKVSHTLYKQLRQVCEEHMKAQI--HQFREDSLDS 122

  Fly   190 LILLEKINHWWLSFCQQMIMIRSIFLYMDRTYVLQNSTVHSIWDMGLDLFRIHFAQNSVVQKRTV 254
            .:.|:|:|..|...|:||||||||||::|||||||||.:.|||||||:|||.|...:.:||.:|:
Frog   123 FLFLKKVNRCWKDHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRCHVVSDRMVQIKTI 187

  Fly   255 DGLLTLIEKERQGSTVDRGLLKSLVRMLCDLQIYTSSFEEKFLDATNQLYKAESQRKMQELEVPE 319
            ||:|.|||:||.|..|||.||:||:.||.|||:|..|||.|||:.||.||.||.||.|||.||||
Frog   188 DGILKLIEQERSGEAVDRSLLRSLLGMLSDLQVYKESFETKFLEETNCLYAAEGQRLMQEREVPE 252

  Fly   320 YLQHVNKRLAEENERLRHYLDSSTKHPLIYNVEKELLAEHLTSILQKGLDSLLEDNRLSDLTLLY 384
            ||.|||:||.||.:|:..|||..|..|||..|||:||.||||:||||||.::|::||..:|||:|
Frog   253 YLHHVNRRLEEEVDRVITYLDHGTHKPLIACVEKQLLGEHLTAILQKGLKNMLDENRDPELTLMY 317

  Fly   385 GLLSRVKNGTSELCGNFNGFIKKKGRTIVIDPEKDKSMVQDLLDFKDKMDVIVRTCFEHNEKFTN 449
            .|.||||.|...|..::..:||..|..:||:|||||.|||:||||||.:|.|:..||:.||||.|
Frog   318 QLFSRVKGGQIILLQHWGEYIKNFGSGLVINPEKDKDMVQELLDFKDNVDHIIDVCFQKNEKFVN 382

  Fly   450 SLREAFEFFINQRANKPAELIAKYVDMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFY 514
            :::|:||.|||:||||||||||||||.|||||||..||||||:.|||||::||||||||||||||
Frog   383 TMKESFETFINRRANKPAELIAKYVDSKLRSGNKEATDEELERLLDKIMIIFRFIHGKDVFEAFY 447

  Fly   515 KKDLAKRLLVGKSASVDSEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRD 579
            |||||||||||||||||||||||||||.|||..|||||||||||||||:|:.:.|:.| :.|:.|
Frog   448 KKDLAKRLLVGKSASVDSEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDVMVQFKQH-MQNHSD 511

  Fly   580 VHNLDLCVSILTMGYWPTYAPTEVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQF 644
            ..|:||.|:||||||||||.|.:|.:|.:.:..|:||..|||.|||||:||||.|||:.:|:|.|
Frog   512 PGNIDLTVNILTMGYWPTYTPVDVHLPAEMVKLQEIFKAFYLGKHSGRRLQWQSTLGHAVLKADF 576

  Fly   645 DAGPKELLVSLFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACGRARVITKTPKGRE 709
            ....|||.|||||.|||||||......:|||...|.|||.||||||||||||:|||:.|:||.::
Frog   577 KEEKKELQVSLFQTLVLLLFNKGDEFGFEEIKITTGIEDNELRRTLQSLACGKARVLNKSPKSKD 641

  Fly   710 ILDGDQFDFNNEFTNKLFRIKINQIQMKETNEEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSH 774
            :.|||:|.||.:|.:||:||||||||||||.|||..|.|||||||||||||||||||||||||:|
Frog   642 VEDGDRFCFNADFKHKLYRIKINQIQMKETVEEQVNTTERVFQDRQYQIDAAIVRIMKMRKTLTH 706

  Fly   775 NLLITELFNQLTFPVKPADLKKRIESLIDRDYMERDKDNQNQYNYVA 821
            |||::||:|||.|||||.|||||||||||||||||||||..||:|:|
Frog   707 NLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNAKQYHYLA 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_001163084.1	Cullin	124..721	CDD:279260	373/596 (63%)
		CULLIN	503..644	CDD:214545	99/140 (71%)
		Cullin_Nedd8	750..815	CDD:214883	58/64 (91%)
cul4a	NP_001015893.1	Cullin	58..653	CDD:279260	373/597 (62%)
		CULLIN	436..576	CDD:214545	99/140 (71%)
		Cullin_Nedd8	682..747	CDD:214883	58/64 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	732	1.000	Domainoid score	I109
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	944	1.000	Inparanoid score	I339
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	1	1.000	-	-		otm49263
Panther	1	1.100	-	-	LDO	PTHR11932
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1830
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160