Protein Alignment Cul4 and mr

DIOPT Version :9

• Sequence 1: NP_001163084.1
• Gene: Cul4 / 35780
• FlyBaseID: FBgn0033260
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: NP_611862.1
• Gene: mr / 45906
• FlyBaseID: FBgn0002791
• Length: 802
• Species: Drosophila melanogaster
• Alignment Length: 689
• Identity: 128/689 - (18%)
• Similarity: 246/689 - (35%)
• Gaps: 195/689 - (28%)

  Fly    82 SNLLNRMGAIHNS-------KPGDVKKIVIKNFKDKPTLPDNYSKDTYVKLEEAV-------IAI 132
            :..::.:..:|:|       ||   :.|.:...:.|||     :|...:..||.:       :..
  Fly   105 TQFIDAINELHDSFQSLMQVKP---RLIQLVGAETKPT-----AKTVKLMQEEGIKNCLRDCLLA 161

  Fly   133 QLSKPIKYSLE---------ELYQAVVNMCSHKMDAQLYAKL--------------KELTEQHVK 174
            ||  |..:|:.         :|:....|:....:|:.::.:|              :.||:...|
  Fly   162 QL--PPNFSVVVGAFYWVHFKLFTKASNLALTTVDSDVFDELLCVGCNFEAEQCCCQRLTDMVNK 224

  Fly   175 RNIKLKE------LTGGSMDKLILLEKINHWWLSFCQQMIMIRSIFLYMDRTYVLQNSTVHSIWD 233
            .|:||.|      |||.::..||.|:...|                                |.|
  Fly   225 TNMKLFEMNLIDRLTGSALTALIKLKIKEH--------------------------------ISD 257

  Fly   234 MGLDLFRIHFAQNSVVQKRTVDGLLTLIEKERQGSTVDRGLLKSLVRMLCDLQIYTSSFEEKFLD 298
            ..:.:|                               ||..||.|...|.|:.:       .:|
  Fly   258 TCMGIF-------------------------------DRSHLKQLETWLSDVIM-------SWL- 283

  Fly   299 ATNQLYKAESQRKMQELEVPEYLQHVNKRL--------AEE--NERLRHYLDSSTKHPLIYN--- 350
             ||...:.:|:..:.::||||.::....:|        |:.  .:.....:|.....|.|.:
  Fly   284 -TNIFTEWKSKDSISDIEVPESVKSFKVKLTYFMYETFAQSVIGQFFSIIIDYPDSIPAIDDLKI 347

  Fly   351 -VEKELLAEHLTSILQKGLDSLLEDNRLSDLTLLYGLLSRVK-----NGTSEL----CGNFNGFI 405
             :||..:..:||..|:..|::.:....::.:.:|.|.::.:|     :.|..:    ......::
  Fly   348 CMEKIDMRVYLTESLRNSLEARILHPGVNTMDILTGYVAAIKAIRHLDSTGVILEMVTAPIKDYL 412

  Fly   406 KKKGRTI--VIDPEKDKSMVQDLLDFKDKMDVIVRTCFEHNEKFTN---------SLREAFEFFI 459
            :|:..|:  |:....::... ||.:...|.:.|........::|:|         .:..:...:.
  Fly   413 RKRNDTVRRVVTGLTEEGPT-DLSEELAKGETIKECKDSGTDEFSNWENWQPDPFGIDASIMQYN 476

  Fly   460 NQRANKPAELIAKYVDMKLRSGNKGTTDEELEKTLDKIMVLFRFIHG-KDVFEAFYKKDLAKRLL 523
            :.|..:.|::|:..||                            |:| |::|...|:..:|.|||
  Fly   477 SSRKMRSADIISMVVD----------------------------IYGSKELFMTEYRNLMADRLL 513

  Fly   524 VGKSASVDSEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHN--LDLC 586
            .....:.:.|...|..||...|.......|.|.||:..|:.||    .|..|:.....|  .|:.
  Fly   514 AQLDFNSEKEIRNLELLKIRFGESLLHSCEVMLKDVTDSKRIN----AHIHSDGDRTENQLFDIS 574

  Fly   587 VSILTMGYWPTYAPTEVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGPKEL 651
            ..|::..:||::....:.:|.:..|..:.:.|.|......|.|.|:...|...:..:......|:
  Fly   575 SLIVSAQFWPSFNKESLQLPEEIENEFKKYTKAYEAYKGNRTLNWRTVTGRVNIEIEIGDRTMEM 639

  Fly   652 LVSLFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTL 690
            :||...|:::..|..|...:.|::.:.|.:....|||.|
  Fly   640 VVSPILAVIIYHFQTKNEWTIEDLSSITKVPASALRRRL 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_001163084.1	Cullin	124..721	CDD:279260	119/640 (19%)
		CULLIN	503..644	CDD:214545	36/143 (25%)
		Cullin_Nedd8	750..815	CDD:214883
mr	NP_611862.1	CULLIN	494..632	CDD:214545	35/141 (25%)
		APC2	741..800	CDD:198081

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467934
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930