Protein Alignment Cul4 and Cul5

DIOPT Version :9

• Sequence 1: NP_001163084.1
• Gene: Cul4 / 35780
• FlyBaseID: FBgn0033260
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0039632
• Length: 852
• Species: Drosophila melanogaster
• Alignment Length: 651
• Identity: 184/651 - (28%)
• Similarity: 314/651 - (48%)
• Gaps: 81/651 - (12%)

  Fly   236 LDLFRIHFAQNSVVQKRTVDGLLTLIEKERQGSTVDR----GLLKSLVRMLCD----LQIYTSSF 292
            ||.:..|...:  ::.|..:..:.::..||.|...|.    |:.:|.|.:..:    |:||..:|
  Fly   218 LDSWNKHIFHD--IKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAEDKLEIYRENF 280

  Fly   293 EEKFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENERLRHYLDSSTKHPLIYNVEKELLA 357
            |..:|.||.:.|:.:|..:.||..|..|:::.:.:|.||..|.:.||:.|:...|.|.:...|:.
  Fly   281 EMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSILTYTLVNVLIV 345

  Fly   358 EHLTSILQKGLDSLLEDNRLSDLTLLYGLLSRVKN--GTSELCGNFNGFIKKKG--------RTI 412
            :||.||:.: ..:|:.|.....|.|::.|:.||.:  |...:.|:....|...|        ..|
  Fly   346 DHLNSIIAE-CPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAGLADMLSASEVI 409

  Fly   413 VIDPEKDKSMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFINQRA-------------- 463
            ..|.||   .|:.||:..:|...:||..|..:.:|..:...||:..:|..:
  Fly   410 TQDSEK---YVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMELPTSIANRG 471

  Fly   464 -------NKPAELIAKYVDMKLRSG--NKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLA 519
                   :|..||:|.|.||.||..  :|..|.|:::..|..::::.::::.||||..::|..|.
  Fly   472 VKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYHKVHLT 536

  Fly   520 KRLLVGKSASVDSEKSMLSKLKQECG--GGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHN 582
            :||::|.||..:.|:.::..|: |.|  ..:.::|..||:|:::|.|:|..||  ...:..|..|
  Fly   537 RRLILGTSADSEKEEDIVEWLR-EVGMPADYVNRLARMFQDIKVSEDLNTQFR--TSISRHDAIN 598

  Fly   583 LDLCVSILTMGYWPTYAP-TEVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDA 646
                :.||..|.|...:. ..|::|.:..:......:||.:|||||||||...:.|..:....:.
  Fly   599 ----IKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITFVNNF 659

  Fly   647 GPKELLVSLFQALVLLLFN----DKPVLSYEEILAATLIEDGELRRTLQSLACG---RARVITKT 704
            |..:|.|:.||..||..:|    ||  :|||.:..||.:.|.||||||.||...   :.:::...
  Fly   660 GRYDLDVTTFQMAVLFAWNQRQHDK--ISYENLRLATELPDPELRRTLWSLVAFPKIKKQILLME 722

  Fly   705 PKG----REILDGDQFDFNNEFT-----NKLFRIKIN---QIQMKETNEEQKATEERVFQDRQYQ 757
            |..    ::..:...|..|.||.     ....|.|:|   ::|: .|...|:...:.:.|.|..:
  Fly   723 PAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQL-STERSQQEDNQSIVQLRILR 786

  Fly   758 IDAAIVRIMKMRKTLSHNLLITELFNQLTFPVKPAD--LKKRIESLIDRDYMERDKDNQNQYNYV 820
            ...||::|||:||.:::..|..||.:.|.....|:.  :|:::|.||:..||.||.|:.|.:.||
  Fly   787 TQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDDINMFIYV 851

  Fly   821 A 821
            |
  Fly   852 A 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_001163084.1	Cullin	124..721	CDD:279260	149/539 (28%)
		CULLIN	503..644	CDD:214545	44/143 (31%)
		Cullin_Nedd8	750..815	CDD:214883	23/66 (35%)
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	149/539 (28%)
		CULLIN	520..655	CDD:214545	44/141 (31%)
		Cullin_Nedd8	779..846	CDD:214883	23/66 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467947
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11932
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850