Protein Alignment Cul4 and Cul6

DIOPT Version :10

• Sequence 1: NP_610352.2
• Gene: Cul4 / 35780
• FlyBaseID: FBgn0033260
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Alignment Length: 738
• Identity: 158/738 - (21%)
• Similarity: 296/738 - (40%)
• Gaps: 173/738 - (23%)

  Fly   142 LEELYQAVVNMC---------SHKMDAQLYAKLKELTEQHVKRNIKLKELTGGSMDKLILLEK-I 196
            |..||..:...|         :.|....||..|.:...:.:|....:.|........:.|:.| :
  Fly    40 LMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDCLMKRLKNIAWVMENQLDDNKPIRLIAKYL 104

  Fly   197 NHW--WLSFCQQMIMIRSIF--LYMDRTYVLQNSTVHSIWDMGLDLFRIHFAQNSVVQKRTVDGL 257
            .||  :...|:::.:....|  .:::|..:..:...:.|:.:.:..::....:.||.....:..:
  Fly   105 EHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKETYPIYRLAMISWKELVFEPSVTILAAIRLI 169

  Fly   258 LTLIEKERQGSTVDR--GLLKSLVRMLCDLQIYTSS--------FEEKFLDATNQLYKAESQRKM 312
            |:.:.:|...|...:  .:|:|:|.:..:.:....|        |.||.:|    .||:.:..:.
  Fly   170 LSQMPREYNKSLEYQVYQVLQSIVELYANDKYQDVSLPSRIDKIFTEKVMD----FYKSTTLHEF 230

  Fly   313 QELEVPEYLQHVNKRLAEENERLRHYLD-SSTKHPLIYNVEKELLAEHLTSILQKGLDSLLEDNR 376
            |::.|           :.:.:..:|:|. :....|.|.|      .....:||::.|.:.|::.|
  Fly   231 QKIVV-----------SNDYKDFKHFLRYACLAMPEIEN------GTQFKAILKRYLAARLQETR 278

  Fly   377 LSD-------LTLLYGLLSRVKNGTSELCGNFNGF----IKKKGRTIVIDPEKDKSMVQDLLDFK 430
            ||.       |.|..|.|.|.....::|....:..    |.:||:  :|||
  Fly   279 LSGKDYIQAFLGLCRGPLQRALRDHTKLAEVVDAVCKEEINRKGQ--IIDP-------------- 327

  Fly   431 DKMDVIVRTCFEHNEKFTNSLREAFEFFINQ--RANKPAELIA---KYVDM-----KLRSGNKGT 485
                  .|....:..:.....:|:.|..|::  |..|..|.::   |::||     ::|..|:.:
  Fly   328 ------TRLLVTYANELMTKRQESEEAIIDELKRIVKCVEFLSDEYKFIDMYLKALRIRQINETS 386

  Fly   486 TDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDSEKSMLSKLKQECGGGFTS 550
            |.:.:|.      :::..::.|       ..:...|.:..:...||.    |..||:|
  Fly   387 TSDGVES------IMYSLLNKK-------MANFVTRCIYVQLRDVDK----LRTLKKE------- 427

  Fly   551 KLEGMFKDMELSRDINIA--FRGHALSNNRDVHNLDLCVSILTMGYWPTYAPTEVTMPPQFINPQ 613
                 |:|...|:.|.:.  ||.....|:....|.:|                  |:|.:.....
  Fly   428 -----FQDHLNSKGIKLGFDFRPKCFKNDGSFENFNL------------------TLPDELQQAW 469

  Fly   614 QIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGPKE---------LLVSLFQALVLLLFNDKPV 669
            :.|..||    ..||||.:..:   .|..:..:|...         |.||..|..||:|||....
  Fly   470 KEFRIFY----EARKLQSKAII---QLNNELSSGEITCHLNQSVYILEVSTLQMAVLMLFNRHER 527

  Fly   670 LSYEEILAATLIEDGELRRTLQSLACGRARVITKTPKGREILDGDQFDFNNEFTNKLFRIKINQI 734
            .:.:|::.|..:|...|:..|:.:   :..|..:..|...|      :.|.:|||:..|:..|:.
  Fly   528 FTEQELVTALGVELETLQEALKQI---KFLVYIEVNKVNYI------EINMDFTNRKRRLFCNEP 583

  Fly   735 QMKETN--EEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITELFNQLTFPVKP--ADLK 795
            ..::..  ||:...|.::.:|:  |:|||||||||.:|.|.::.||:.::.:|...|||  :.:|
  Fly   584 LPRKMRKIEEKSEIELKIRRDK--QVDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIK 646

  Fly   796 KRIESLIDRDYMERDKDNQNQYN 818
            ||::.|::|:|:|||    |.||
  Fly   647 KRLDYLVEREYLERD----NYYN 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_610352.2	Cullin	124..722	CDD:459983	119/636 (19%)
		Cullin_Nedd8	753..813	CDD:463146	28/61 (46%)
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	158/738 (21%)