DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul4 and AT1G43140

DIOPT Version :9

Sequence 1:	NP_001163084.1	Gene:	Cul4 / 35780	FlyBaseID:	FBgn0033260	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_175007.2	Gene:	AT1G43140 / 3767291	AraportID:	AT1G43140	Length:	721	Species:	Arabidopsis thaliana

Alignment Length:	768	Identity:	243/768 - (31%)
Similarity:	384/768 - (50%)	Gaps:	100/768 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 KIVIKNFKDKPTLPDNYS--KDTYVKLEEAVIAIQLSKPI----KYSLEELYQAVVNMC----SH 155
            |:::  .|:...|.:.:|  |....||:.  |...||:|.    :|.  .||..:.:||    .:
plant     7 KVIM--MKELILLEEGWSVMKTGVAKLQR--ILEDLSEPPFDPGQYI--NLYTIIYDMCLQQPPN 65

  Fly   156 KMDAQLYAKLKELTEQHVKRNI--KLKELTGGSMDKLILLEKINHW--------WLS-FCQQMIM 209
            ....:||.|.:.:.:.:.|..:  .::|..|    :.:|.|.:..|        ||| ||
plant    66 DYSQELYNKYRGVVDHYNKETVLPSMRERHG----EYMLRELVKRWANHKILVRWLSRFC----- 121

  Fly   210 IRSIFLYMDRTYVLQNSTVHSIWDMGLDLFRIHFAQNSVVQKRTVDGLLTLIEKERQGSTVDRGL 274
                 .|:||.||.:.. :.::.|:|...|  |......:|....|.||.||.|||:|..:||.|
plant   122 -----FYLDRFYVARRG-LPTLNDVGFTSF--HDLVYQEIQSEAKDVLLALIHKEREGEQIDRTL 178

  Fly   275 LKSLVRMLC-----DLQIYTSSFEEKFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENER 334
            :|:::.:.|     .:.||...||...|..|...|..::.|..||...|:|:....:.|..|.||
plant   179 VKNVIDVYCGNGVGQMVIYEEDFESFLLQDTASYYSRKASRWSQEDSCPDYMLKAEECLKLEKER 243

  Fly   335 LRHYLDSSTKHPLIYNVEKELL---AEHLTSILQKGLDSLLEDNRLSDLTLLYGLLSRVKNGTSE 396
            :.:||.|:|:..|:..|:.|||   |:.|......|..:||.|:::.||:.:|.|...:..|...
plant   244 VTNYLHSTTEPKLVEKVQNELLVVVAKQLIENEHSGCLALLRDDKMGDLSRMYRLYRLIPQGLEP 308

  Fly   397 LCGNFNGFIKKKGRTIV---------IDPEKDKSMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLR 452
            :...|...:..:|..::         .|....:.:|:..::..||..|.|..||:.:..|...|:
plant   309 IADLFKQHVTAEGNALIKQAADAATNQDASASQVLVRKEIELHDKYMVYVDECFQKHSLFHKLLK 373

  Fly   453 EAFEFFINQ--RANKPAELIAKYVD--MKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAF 513
            ||||.|.|:  .....||::|.|.|  :|.|.|::..:||..|.||:|::.|..:|..||:|..|
plant   374 EAFEVFCNKTVAGASSAEILATYCDNILKTRGGSEKLSDEATEITLEKVVNLLVYISDKDLFAEF 438

  Fly   514 YKKDLAKRLLVGKSASVDSEKSMLSKLKQECGGGFTSKLEGMFK---DMELSRDINIAFRGHALS 575
            |:|..|:|||..:|                          |:.|   |:.|:|::...|..:..:
plant   439 YRKKQARRLLFDRS--------------------------GIMKEVTDITLARELQTNFVDYLSA 477

  Fly   576 NNRDVHNLDLCVSILTMGYWPTYAPTEVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCML 640
            |......:|..|::||.|:||:|..|::.:|.:.:|..:.|..||..|.:.|:|.|..:||.|.:
plant   478 NMTTKLGIDFTVTVLTTGFWPSYKTTDLNLPTEMVNCVEAFKVFYGTKTNSRRLSWIYSLGTCHI 542

  Fly   641 RAQFDAGPKELLVSLFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACGRARVITKTP 705
            ..:|:....||:||.:||.||||||:...|||.||.....:...:|.|.|.||:|.:.:::.|.|
plant   543 LGKFEKKTMELVVSTYQAAVLLLFNNAERLSYTEISEQLNLSHEDLVRLLHSLSCLKYKILIKEP 607

  Fly   706 KGREILDGDQFDFNNEFTNKLFRIKINQIQMKETNEEQKATEERVFQDRQYQIDAAIVRIMKMRK 770
            ..|.|...|.|:||::||:|:.:|::....|    :|:|...|.|.:||:|.||||:|||||.||
plant   608 MSRTISKTDTFEFNSKFTDKMRKIRVPLPPM----DERKKVVEDVDKDRRYAIDAALVRIMKSRK 668

  Fly   771 TLSHNLLITELFNQLTFPVKP--ADLKKRIESLIDRDYMERDKDNQNQYNYVA 821
            .|:|..|::|....|:...||  ..:|||||.||:|||:|||.:|.|.:.|||
plant   669 VLAHQQLVSECVEHLSKMFKPDIKMIKKRIEDLINRDYLERDTENANTFKYVA 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_001163084.1	Cullin	124..721	CDD:279260	190/639 (30%)
		CULLIN	503..644	CDD:214545	40/143 (28%)
		Cullin_Nedd8	750..815	CDD:214883	36/66 (55%)
AT1G43140	NP_175007.2	Cullin	48..623	CDD:279260	184/619 (30%)
		CULLIN	428..546	CDD:214545	40/143 (28%)
		Cullin_Nedd8	653..713	CDD:287520	32/59 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.790