Protein Alignment Cul4 and Cul1

DIOPT Version :10

• Sequence 1: NP_610352.2
• Gene: Cul4 / 35780
• FlyBaseID: FBgn0033260
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: NP_001102097.1
• Gene: Cul1 / 362356
• RGDID: 1308157
• Length: 776
• Species: Rattus norvegicus
• Alignment Length: 813
• Identity: 243/813 - (29%)
• Similarity: 391/813 - (48%)
• Gaps: 116/813 - (14%)

  Fly    88 MGAIHNSKPGDVKKIVIKNFKD--KPTLPDNYSKDTYVKLEEAVIAIQLSKPIKYSLEELYQAVV 150
            |.:..:..|..:|:|.:....|  :..:...|::.:..|             .:|.  |||..|.
  Rat     1 MSSNRSQNPHGLKQIGLDQIWDDLRAGIQQVYTRQSMAK-------------SRYM--ELYTHVY 50

  Fly   151 NMCS--HK-------------------------MDAQLYAKLKELTEQHVKRNIKLKELTGGSMD 188
            |.|:  |:                         :..:||.:|||..:.::...:|..|   ..||
  Rat    51 NYCTSVHQSNQARGAGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGE---DLMD 112

  Fly   189 KLILLEKINHWWLSFCQQMIMIRSIFLYMDRTYVLQ-----NSTVHSIWDMGL-----DLFRIHF 243
            :.: |:.....|..:.....::..|..|::|.:|.:     ...::.|:.:.|     .|||
  Rat   113 ESV-LKFYTQQWEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFR--- 173

  Fly   244 AQNSVVQKRTVDGLLTLIEKERQGSTVDRGLLKSLVRMLCD--------------LQIYTSSFEE 294
                .:.|:..:.:|.||||||.|.|::..|:..:|:...:              |.:|..|||.
  Rat   174 ----PLNKQVTNAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFES 234

  Fly   295 KFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENERLRHYLDSSTKHPLIYNVEKELLAEH 359
            :||..|.:.|..||...:|:..|.||::....||.||..|::.||..||:..|....|:.|:.:|
  Rat   235 QFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKH 299

  Fly   360 LTSILQKGLDSLLEDNRLSDLTLLYGLLSRVKNGTSELCGNFN--------GFIKKKGRTIVIDP 416
            | .|......:||:.::..||..:|.|:||:::|..||.....        ..|:|.|...:.||
  Rat   300 L-EIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDP 363

  Fly   417 EKDKSMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFIN--------QRANKPAELIAKY 473
               |..||.:||...|.:.:|.:.|.::..|..:|.:|...|||        |.::|..||:|:|
  Rat   364 ---KMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARY 425

  Fly   474 VDMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDSEKSMLS 538
            .|..|:..:|...:.|||.||:::||:|::|..||||:.||.|.|||||:...|||.|:|.||:|
  Rat   426 CDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMIS 490

  Fly   539 KLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVSILTMGYWPTYAPTEV 603
            ||||.||..:||||:.||:|:.:|:|:|..|:.| |:|:..: :||..:.:|:.|.||.......
  Rat   491 KLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKH-LTNSEPL-DLDFSIQVLSSGSWPFQQSCTF 553

  Fly   604 TMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGPKELLVSLFQALVLLLFNDKP 668
            .:|.:.....|.|..||..:||||||.|...|....|..........|..|.||..:||.:|.:.
  Rat   554 ALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTED 618

  Fly   669 VLSYEEILAATLIEDGELRRTLQSLACGRARVITKTPKGREILDGDQFDFNNE--------FTNK 725
            ..:.:::..:|.|:...|.:.||.|...:..|:..     |..:.|:.:...:        :.||
  Rat   619 AYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLED-----ENANVDEVELKPDTLIKLYLGYKNK 678

  Fly   726 LFRIKINQIQMKETNEEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITELFNQLTFPVK 790
            ..|:.||.....|..:||:.|.:.:.:||:..|.|||||||||||.|.|..|:.|:..||:...|
  Rat   679 KLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFK 743

  Fly   791 P--ADLKKRIESLIDRDYMERDKDNQNQYNYVA 821
            |  ..:||.|:.||:::|:||....::.|:|:|
  Rat   744 PRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_610352.2	Cullin	124..722	CDD:459983	195/672 (29%)
		Cullin_Nedd8	753..813	CDD:463146	30/61 (49%)
Cul1	NP_001102097.1	Cullin	21..660	CDD:459983	196/675 (29%)
		Cullin_Nedd8	706..768	CDD:463146	30/61 (49%)