Protein Alignment Cul4 and Cul2

DIOPT Version :10

• Sequence 1: NP_610352.2
• Gene: Cul4 / 35780
• FlyBaseID: FBgn0033260
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: NP_001386142.1
• Gene: Cul2 / 361258
• RGDID: 1310644
• Length: 745
• Species: Rattus norvegicus
• Alignment Length: 771
• Identity: 226/771 - (29%)
• Similarity: 373/771 - (48%)
• Gaps: 94/771 - (12%)

  Fly    99 VKKIVIKNFKDKPTLPDNYSKDTYVKLEEAVIAIQLSKPIKYSLEELYQAVVNMCSHKMDAQLYA 163
            :|.:|:..:.::.|..|.:| |.|      .:.:...:|                   :..:|||
  Rat    21 IKAVVMLEYVERATWNDRFS-DIY------ALCVAYPEP-------------------LGERLYA 59

  Fly   164 KLKELTEQHV----KRNIKLKELTGGSMDKLILLEKINHWWLSFCQQMIMIRSIFLYMDRTYVLQ 224
            :.|...|.||    ||.::.:|.         :|...:.:|..:.:....:..::.|::..|:.:
  Rat    60 ETKIFLENHVRHLYKRVLESEEQ---------VLVMYHRYWEEYSKGADYMDCLYRYLNTQYIKK 115

  Fly   225 NSTVHS-----------------IWDMGLDLFR---IHFAQNSVVQKRTVDGLLTLIEKERQG-- 267
            |....:                 |.::.||::|   :...||.:::.     ||..|:.:|.|
  Rat   116 NKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQNILIRM-----LLREIKNDRGGED 175

  Fly   268 --STVDRGLLKSLV-----RMLCDLQIYTSSFEEKFLDATNQLYKAESQRKMQELEVPEYLQHVN 325
              ..|..|::.|.|     :....|:.|...|...||..|.:.||.|:...:||....:|::.|.
  Rat   176 PNQKVIHGVINSFVHVEQYKKKFPLKFYQGIFVSPFLTETGEYYKQEASNLLQESNCSQYMEKVL 240

  Fly   326 KRLAEENERLRHYLDSSTKHPLIYNVEKELLAEHLTSILQKGLDSLLEDNRLSDLTLLYGLLSRV 390
            .||.:|..|.|.||..|:...:|:..::.::|:|| ..|.....|::...|.:|:..:|.||..|
  Rat   241 GRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHL-QFLHSECHSIIRHERKNDMANMYVLLRAV 304

  Fly   391 KNGTSELCGNFNGFIKKKG--RTIVIDPEKDKSM-VQDLLDFKDKMDVIVRTCFEHNEKFTNSLR 452
            .:|...:.......|..:|  .|..:..|...:: |:.:|:...|...::.|....::.|.::|.
  Rat   305 SSGLPHMIEELQRHIHDEGLRATSNLTQEHMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALD 369

  Fly   453 EAFEFFINQRANKPA----ELIAKYVDMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAF 513
            :|....:|.|..|..    ||:|||.|..|:...||.|:.|:|..|...:.:|::|..||||:.|
  Rat   370 KALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDKLTSFITVFKYIDDKDVFQKF 434

  Fly   514 YKKDLAKRLLVGKSASVDSEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNR 578
            |.:.|||||:.|.|.|:|||::|::||||.||..|||||..|:.||.:|.|:|..|..  ...|:
  Rat   435 YARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNN--FIRNQ 497

  Fly   579 DVHNLDLCVS----ILTMGYWP-TYAPTEVTMPPQFINPQ-QIFNKFYLEKHSGRKLQWQPTLGN 637
            |. .:||.:|    :|..|.|| |.||:.....||.:... |:|..||.:..|||||.|...|..
  Rat   498 DT-VIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCT 561

  Fly   638 CMLRAQFDAGPKELLVSLFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACGRARVIT 702
            ..::..:...|...:|:.:|..|||.||:...:||:|:..:|.:.:.||.:|::||.  ..::|.
  Rat   562 GEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLL--DVKMIN 624

  Fly   703 KTPKGREILDGDQFDFNNEFTNKLFRIKINQIQMKETNEEQKATEERVFQDRQYQIDAAIVRIMK 767
            ...:..:|.....|..|..|::|..:.||.....|:|.:|.:.|...|.:||:..:.||||||||
  Rat   625 HDSEKEDIDAESSFSLNMSFSSKRTKFKITTSMQKDTPQELEQTRSAVDEDRKMYLQAAIVRIMK 689

  Fly   768 MRKTLSHNLLITELFNQLTFPVKP--ADLKKRIESLIDRDYMERDKDNQNQYNYVA 821
            .||.|.||.||.|:.:|......|  :.:||.||.|||:.|:||.:.:.::|:|||
  Rat   690 ARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_610352.2	Cullin	124..722	CDD:459983	176/643 (27%)
		Cullin_Nedd8	753..813	CDD:463146	30/61 (49%)
Cul2	NP_001386142.1	Cullin	14..644	CDD:459983	183/668 (27%)
		Cullin_Nedd8	675..735	CDD:463146	30/59 (51%)