DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul4 and Cul4a

DIOPT Version :9

Sequence 1:	NP_001163084.1	Gene:	Cul4 / 35780	FlyBaseID:	FBgn0033260	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_001120773.1	Gene:	Cul4a / 361181	RGDID:	1563853	Length:	759	Species:	Rattus norvegicus

Alignment Length:	759	Identity:	488/759 - (64%)
Similarity:	591/759 - (77%)	Gaps:	10/759 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 GGSHGEIRTASTTSNLLNRMGAIHN--SKPGDV---KKIVIKNFKDKPTLPDNYSKDTYVKLEEA 128
            |...|.:......:|.|.:..|:.:  :|||..   :|:|||||:|:|.|||||::||:.||.||
  Rat     5 GPRKGSVSALMGRTNGLTKPAALASGPAKPGGTGGSRKLVIKNFRDRPRLPDNYTQDTWRKLHEA 69

  Fly   129 VIAIQLSKPIKYSLEELYQAVVNMCSHKMDAQLYAKLKELTEQHVKRNI-KLKELTGGSMDKLIL 192
            |.|||.|..|:|:||||||||.|:||||:...||.:|:::.|.||:..| ..:|   .|:|.::.
  Rat    70 VKAIQSSTSIRYNLEELYQAVENLCSHKVSPTLYKQLRQVCEDHVQAQILPFRE---DSLDSVLF 131

  Fly   193 LEKINHWWLSFCQQMIMIRSIFLYMDRTYVLQNSTVHSIWDMGLDLFRIHFAQNSVVQKRTVDGL 257
            |:|||..|...|:||||||||||::|||||||||.:.|||||||:|||.|...:.:||.:|:||:
  Rat   132 LKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRNHIISDRMVQSKTIDGI 196

  Fly   258 LTLIEKERQGSTVDRGLLKSLVRMLCDLQIYTSSFEEKFLDATNQLYKAESQRKMQELEVPEYLQ 322
            |.||.:||.|..|||.||:||:.||.|||:|..|||.|||:.||.||.||.||.||:.||||||.
  Rat   197 LLLIGRERSGEAVDRSLLRSLLSMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQDREVPEYLN 261

  Fly   323 HVNKRLAEENERLRHYLDSSTKHPLIYNVEKELLAEHLTSILQKGLDSLLEDNRLSDLTLLYGLL 387
            ||:|||.||.:|:..|||.||:.|||..|||:||.||||:||||||:.||::||:.|||.:|.|.
  Rat   262 HVSKRLEEEADRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLEQLLDENRVPDLTQMYQLF 326

  Fly   388 SRVKNGTSELCGNFNGFIKKKGRTIVIDPEKDKSMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLR 452
            ||||.|...|..:::.:||..|.||||:|||||.|||||||||||:|.:|..||:.||:|.|.::
  Rat   327 SRVKGGQHALLQHWSEYIKTFGTTIVINPEKDKDMVQDLLDFKDKVDHVVEVCFQRNERFINLMK 391

  Fly   453 EAFEFFINQRANKPAELIAKYVDMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKD 517
            |:||.|||:|.|||||||||:||.|||:|||..||||||:.|||||:||||||||||||||||||
  Rat   392 ESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERILDKIMILFRFIHGKDVFEAFYKKD 456

  Fly   518 LAKRLLVGKSASVDSEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHN 582
            ||||||||||||||:|||||||||.|||..|||||||||||||||:||.:.|:.| :.|......
  Rat   457 LAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQH-MQNQSAPGP 520

  Fly   583 LDLCVSILTMGYWPTYAPTEVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAG 647
            :||.|:||||||||||.|.||.:||:.:..|::|..|||.||||||||||.|||:.:|:|.|..|
  Rat   521 IDLTVNILTMGYWPTYTPMEVHLPPEMVRLQEVFKTFYLGKHSGRKLQWQTTLGHAVLKADFKEG 585

  Fly   648 PKELLVSLFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACGRARVITKTPKGREILD 712
            .||..|||||.||||:||:....|:|||..||.|||.||||||||||||:|||:.|:|||:|:.|
  Rat   586 KKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVED 650

  Fly   713 GDQFDFNNEFTNKLFRIKINQIQMKETNEEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLL 777
            ||:|.||.:|.:|||||||||||||||.|||.:|.|||||||||||||||||||||||||.||||
  Rat   651 GDKFIFNADFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLL 715

  Fly   778 ITELFNQLTFPVKPADLKKRIESLIDRDYMERDKDNQNQYNYVA 821
            ::||:|||.|||||.||||||||||||||||||||:.|||:|||
  Rat   716 VSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDSPNQYHYVA 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_001163084.1	Cullin	124..721	CDD:279260	380/597 (64%)
		CULLIN	503..644	CDD:214545	99/140 (71%)
		Cullin_Nedd8	750..815	CDD:214883	57/64 (89%)
Cul4a	NP_001120773.1	Cullin	63..660	CDD:395716	380/600 (63%)
Cul4a	NP_001120773.1	Cullin_Nedd8	688..753	CDD:214883	57/64 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353692
Domainoid	1	1.000	759	1.000	Domainoid score	I84
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	979	1.000	Inparanoid score	I296
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	1	1.000	-	-		otm46179
orthoMCL	1	0.900	-	-		OOG6_101788
Panther	1	1.100	-	-	LDO	PTHR11932
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1830
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770