DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul4 and Cul1

DIOPT Version :9

Sequence 1:	NP_001163084.1	Gene:	Cul4 / 35780	FlyBaseID:	FBgn0033260	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster

Alignment Length:	708	Identity:	222/708 - (31%)
Similarity:	366/708 - (51%)	Gaps:	56/708 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 QLYAKLKELTEQHVKRNI-KLKELTGGSMDKLILLEKINHWWLSFCQQMIMIRSIFLYMDRTYVL 223
            :||.:|::..:.::...: |.|.::|    :.:||.:....|.|:.....::..|..|::|.:|.
  Fly    77 KLYDRLEQFLKSYLSELLTKFKAISG----EEVLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVK 137

  Fly   224 Q-----NSTVHSIWDMGLDLFRIHFAQNSVVQKRTVDGLLTLIEKERQGSTVDRGLLKSLVRMLC 283
            :     ...::.|:.:.|..::.|..|  |:.:.....:|..||:||||..::|.|::.::....
  Fly   138 RECEEGQKGIYKIYRLALVAWKGHLFQ--VLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECYV 200

  Fly   284 D--------------LQIYTSSFEEKFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENER 334
            :              |.:|..:||.||:..|:..|:.||...:....|.|||:||..||.||.:|
  Fly   201 ELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQR 265

  Fly   335 LR--------HYLDSSTKHPLIYNVEKELLAEHLTSILQKGLDSLLEDNRLSDLTLLYGLLSRVK 391
            :|        .||..:|...|....|:.|:.:|| .|......:||..:|..||..:|.|::...
  Fly   266 VRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHL-KIFHTEFQNLLNADRNDDLKRMYSLVALSS 329

  Fly   392 NGTSELCGNFNGFIKKKG-----RTIVIDPEKD-KSMVQDLLDFKDKMDVIVRTCFEHNEKFTNS 450
            ...::|.......|..:|     :....|...| |:.||.:||...|.:.:|.|.|.::..|..:
  Fly   330 KNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNALVLTAFNNDNGFVAA 394

  Fly   451 LREAFEFFINQR-------ANKPAELIAKYVDMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKD 508
            |.:|...|||..       |:|..||:|||.|:.|:..:|...|:|||..|:::||:|::|..||
  Fly   395 LDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMVVFKYIEDKD 459

  Fly   509 VFEAFYKKDLAKRLLVGKSASVDSEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHA 573
            ||:.:|.|.|||||:...|||.|:|..|:|||||.||..:|.||:.||:|:.:|:|:|..|:.:.
  Fly   460 VFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSYFKQYL 524

  Fly   574 LSNNRDVHNLDLCVSILTMGYWPTYAPTEVTMPPQFINPQQIFNKFYLEKHSGRKLQW--QPTLG 636
            ...|..: .:|..:.:|:.|.||........:|.:.....:.||:||..:||||||.|  |...|
  Fly   525 AEKNLTM-EIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRKLNWLYQMCKG 588

  Fly   637 NCMLRA-QFDAGPKELLVSLFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACGRARV 700
            ..::.. :.::....|..|.||..|||.|||:...:.:::...|..:...|.:.||.|.  :|:|
  Fly   589 ELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILL--KAKV 651

  Fly   701 ITKTPKGREILDGDQFDFNNEFTNKLFRIKINQIQMKETNEEQKATEERVFQDRQYQIDAAIVRI 765
            :|.:.....:......:...::.||..||.|||....|...||:...:.:.:||:..|.||||||
  Fly   652 LTSSDNENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEEDRKLLIQAAIVRI 716

  Fly   766 MKMRKTLSHNLLITELFNQLTFPVKP--ADLKKRIESLIDRDYMERDKDNQNQYNYVA 821
            |||||.|:|..||:|:.|||:...||  ..:||.|:.||:::|:||.:.:::.|:|:|
  Fly   717 MKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_001163084.1	Cullin	124..721	CDD:279260	177/604 (29%)
		CULLIN	503..644	CDD:214545	55/143 (38%)
		Cullin_Nedd8	750..815	CDD:214883	32/66 (48%)
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	177/601 (29%)
		CULLIN	454..593	CDD:214545	55/139 (40%)
		Cullin_Nedd8	701..765	CDD:214883	32/63 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467940
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11932
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850