DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul4 and cul3a

DIOPT Version :9

Sequence 1:	NP_001163084.1	Gene:	Cul4 / 35780	FlyBaseID:	FBgn0033260	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_955985.2	Gene:	cul3a / 324655	ZFINID:	ZDB-GENE-030131-3376	Length:	774	Species:	Danio rerio

Alignment Length:	775	Identity:	296/775 - (38%)
Similarity:	449/775 - (57%)	Gaps:	57/775 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 NSKPGDVK--KIVIKNFKDKPTLPDNYSKDTYVKLEEAVIAIQLSKPIKYSLEELYQAVVNMCSH 155
            |.|||..|  |:.|:.|  ..|:.:.|..:.:..|:.|:..||.......|.||||:....|..|
Zfish    11 NLKPGTKKDTKMRIRAF--PMTMDEKYVNNIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLH 73

  Fly   156 KMDAQLYAKLKELTEQHVKRNIK---LKELTGGSMDKLILLEKINHWWLSFCQQMIMIRSIFLYM 217
            |...:||..|:|:..:|:...::   |..|...      .|:.:|..|......|:|||.|.:||
Zfish    74 KHGEKLYTGLREVVTEHLINKVREDVLHSLNNN------FLQTLNQAWNDHQTAMVMIRDILMYM 132

  Fly   218 DRTYVLQNSTVHSIWDMGLDLFRIHFAQNSVVQKRTVDGLLTLIEKERQGSTVDRGLLKSLVRML 282
            ||.||.||: |.:::::||.:||....:...::......||.:|.:||:|..||||.:::..:||
Zfish   133 DRVYVQQNN-VENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERRGEVVDRGAIRNACQML 196

  Fly   283 CDL-----QIYTSSFEEKFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENERLRHYLDSS 342
            ..|     .:|...||..|||.:.:.::.|||:.:.|.....|::.|..|:.||.||:.|.||.|
Zfish   197 MVLGLEGRSVYEEDFEIPFLDMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKS 261

  Fly   343 TKHPLIYNVEKELLAEHLTSILQ---KGLDSLLEDNRLSDLTLLYGLLSRVKNGTSELCGNFNGF 404
            |:.|::..||:||:::|:.:|::   .||..:|::.:..||..:|.|..||.||...:|...:.:
Zfish   262 TEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFGRVPNGLKTMCECMSWY 326

  Fly   405 IKKKGRTIVIDPEKDKS---MVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFINQRANKP 466
            ::::|:.:|.:..:.|:   .:|.|||.|.:.|..::..|.::..|..::...||:|:|..:..|
Zfish   327 LREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSP 391

  Fly   467 AELIAKYVDMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSASVD 531
             |.::.::|.||:.|.||.|::|:|..|||.||||||:..|||||.:||:.||:|||..||.|.|
Zfish   392 -EYLSLFIDDKLKKGVKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDD 455

  Fly   532 SEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVSILTMGYWP 596
            |||:|:||||.|||..|||||||||:||.:|......||.|..::...:..:||.|.:||.||||
Zfish   456 SEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRHHLQTSQVSLCGVDLTVRVLTTGYWP 520

  Fly   597 TYAPT-EVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGP--KE-------- 650
            |.:.| :..:||...:..::|.:|||.|||||:|..|..:|:..|.|.| .||  ||
Zfish   521 TQSATPKCNIPPSPRHAFEVFRRFYLAKHSGRQLTLQHHMGSADLNATF-YGPIKKEDGSDVGVG 584

  Fly   651 -------------LLVSLFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACGR--ARV 700
                         |.||.||..:|:|||::...::|||...|.|.:.||.|.|||||||:  .||
Zfish   585 GALLTGSNTRKHILQVSTFQMTILMLFNNREKFTFEEIQQETDIPERELVRALQSLACGKPTQRV 649

  Fly   701 ITKTPKGREILDGDQFDFNNEFTNKLFRIKINQIQMK--ETNEEQKATEERVFQDRQYQIDAAIV 763
            :||.||.:||..|..|..|::||:||.|:||..:..|  |::.|:|.|.::|..||:::|:||||
Zfish   650 LTKEPKSKEIESGHVFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIV 714

  Fly   764 RIMKMRKTLSHNLLITELFNQL--TFPVKPADLKKRIESLIDRDYMERDKDNQNQYNYVA 821
            ||||.||.:.||:|:.|:..||  .|...|..:|||||.||:|:|:.|..:::..|.|||
Zfish   715 RIMKSRKKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_001163084.1	Cullin	124..721	CDD:279260	238/636 (37%)
		CULLIN	503..644	CDD:214545	70/141 (50%)
		Cullin_Nedd8	750..815	CDD:214883	32/66 (48%)
cul3a	NP_955985.2	Cullin	41..670	CDD:279260	238/637 (37%)
		CULLIN	427..569	CDD:214545	70/141 (50%)
		Cullin_Nedd8	706..766	CDD:287520	29/59 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.830