DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cul4 and cul1a

DIOPT Version :9

Sequence 1:	NP_001163084.1	Gene:	Cul4 / 35780	FlyBaseID:	FBgn0033260	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_955953.2	Gene:	cul1a / 323883	ZFINID:	ZDB-GENE-030131-2603	Length:	777	Species:	Danio rerio

Alignment Length:	756	Identity:	238/756 - (31%)
Similarity:	376/756 - (49%)	Gaps:	100/756 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 ELYQAVVNMCS--HK--------------------------MDAQLYAKLKELTEQHVKRNIKLK 180
            |||..|.|.|:  |:                          :..:||.:|||..:.::...:|..
Zfish    44 ELYTHVYNYCTSVHQSNQVRGGGPAPSKPSKKTPTPGGAQFVGLELYKRLKEFLKNYLTNLLKDG 108

  Fly   181 ELTGGSMDKLILLEKINHWWLSFCQQMIMIRSIFLYMDRTYVLQ-----NSTVHSIWDMGL---- 236
            |   ..||:.: |:.....|..:.....::..|..|::|.:|.:     ...::.|:.:.|
Zfish   109 E---DLMDESV-LKFYTQQWEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWR 169

  Fly   237 -DLFRIHFAQNSVVQKRTVDGLLTLIEKERQGSTVDRGLLKSLVRMLCD--------------LQ 286
             .|||       .:.|:..:.:|.||||||.|.|::..|:..:|:...:              |.
Zfish   170 ECLFR-------PLNKQVTNAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLS 227

  Fly   287 IYTSSFEEKFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENERLRHYLDSSTKHPLIYNV 351
            :|...||.:||..|.:.|..||...:|:..|.||::....||.||..|::.||..||:..|....
Zfish   228 VYKEYFETQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKC 292

  Fly   352 EKELLAEHLTSILQKGLDSLLEDNRLSDLTLLYGLLSRVKNGTSEL-----CGNFN---GFIKKK 408
            |:.|:.:|| .|......:||:.::..||..:|.|:||:.:|..||     ...:|   ..|:|.
Zfish   293 EQVLIEKHL-EIFHTEFQNLLDADKNEDLGRMYNLVSRITDGLGELKKLLETHIYNQGLAAIEKC 356

  Fly   409 GRTIVIDPEKDKSMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFIN--------QRANK 465
            |.:.:.||   |..||.:||...|.:.:|.:.|.::..|..:|.:|...|||        |.::|
Zfish   357 GESALNDP---KMYVQTILDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMVQSSSK 418

  Fly   466 PAELIAKYVDMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSASV 530
            ..||:|:|.|..|:..:|...:.|||.||:::||:|::|..||||:.||.|.|||||:...|||.
Zfish   419 SPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASD 483

  Fly   531 DSEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVSILTMGYW 595
            |:|.||:|||||.||..:||||:.||:|:.:|:|:|..|:.| |:|:..: :||..:.:|:.|.|
Zfish   484 DAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKH-LTNSEPL-DLDFSIQVLSSGSW 546

  Fly   596 PTYAPTEVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGPKELLVSLFQALV 660
            |........:|.:.....|.|..||..:||||||.|...|....|..........|..|.||..:
Zfish   547 PFQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYHLSKGELVTNCFKNRYTLQASTFQMAI 611

  Fly   661 LLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACGRARVITKTPKGREILDGDQFDFNNE---- 721
            ||.:|.:.|.:.:::..:|.|:...|.:.||.|...:..|:..     |..:.|:.:|..:
Zfish   612 LLQYNTEDVYTVQQLTDSTQIKIDILVQVLQILLKSKLLVLED-----ENANVDEVEFKPDTLIK 671

  Fly   722 ----FTNKLFRIKINQIQMKETNEEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITELF 782
                :.||..|:.||.....|..:||:.|.:.:.:||:..|.|||||||||||.|.|..|:.|:.
Zfish   672 LFLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLAEVL 736

  Fly   783 NQLTFPVKP--ADLKKRIESLIDRDYMERDKDNQNQYNYVA 821
            |||:...||  ..:||.|:.||:::|:||....::.|:|:|
Zfish   737 NQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_001163084.1	Cullin	124..721	CDD:279260	195/644 (30%)
		CULLIN	503..644	CDD:214545	61/140 (44%)
		Cullin_Nedd8	750..815	CDD:214883	31/66 (47%)
cul1a	NP_955953.2	Cullin	22..661	CDD:307166	193/638 (30%)
cul1a	NP_955953.2	Cullin_Nedd8	704..771	CDD:214883	31/66 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.830