Protein Alignment Cul4 and Cul4b

DIOPT Version :10

• Sequence 1: NP_610352.2
• Gene: Cul4 / 35780
• FlyBaseID: FBgn0033260
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: NP_001100421.1
• Gene: Cul4b / 302502
• RGDID: 1564494
• Length: 971
• Species: Rattus norvegicus
• Alignment Length: 817
• Identity: 510/817 - (62%)
• Similarity: 626/817 - (76%)
• Gaps: 18/817 - (2%)

  Fly     5 KKYKPMDTTELHENTENIAACLKKAENVAPTAAAASSVGRSAFAAQNMNSASTNGERLPNFSKLG 69
            ||.:..||.|.      :....|.||.   :::::||...:|..:|...      ::|.|.|.|.
  Rat   173 KKLRFEDTLEF------VGFDTKMAEE---SSSSSSSSSPTAATSQQQQ------QQLKNKSILI 222

  Fly    70 GSHGEIRTASTTSNLLNRMGAIHNSKPGDVKKIVIKNFKDKPTLPDNYSKDTYVKLEEAVIAIQL 134
            .|...:..|:..:.....:.:..|||||..||:|||||||||.||:||:.:|:.||:|||.|||.
  Rat   223 SSVASVHHANGLAKSSTTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQN 287

  Fly   135 SKPIKYSLEELYQAVVNMCSHKMDAQLYAKLKELTEQHVKRNIKLKELTGGSMDKLILLEKINHW 199
            |..|||:||||||||.|:||:|:.|.||.:|:::.|.|:|..|  .:....|:|.::.|:||:..
  Rat   288 STSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQI--HQFREDSLDSVLFLKKIDRC 350

  Fly   200 WLSFCQQMIMIRSIFLYMDRTYVLQNSTVHSIWDMGLDLFRIHFAQNSVVQKRTVDGLLTLIEKE 264
            |.:.|:||||||||||::|||||||||.:.|||||||:|||.|...:..||.:|:||:|.|||:|
  Rat   351 WQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERE 415

  Fly   265 RQGSTVDRGLLKSLVRMLCDLQIYTSSFEEKFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLA 329
            |.|..:||.||:||:.||.|||||..|||::||..||:||.||.|:.|||.||||||.||||||.
  Rat   416 RNGEAIDRSLLRSLLNMLSDLQIYQDSFEQRFLQETNRLYAAEGQKLMQEREVPEYLHHVNKRLE 480

  Fly   330 EENERLRHYLDSSTKHPLIYNVEKELLAEHLTSILQKGLDSLLEDNRLSDLTLLYGLLSRVKNGT 394
            ||.:||..|||.:|:..||.:|||:||.||||:||||||:|||::||:.||:|||.|.|||:.|.
  Rat   481 EEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGV 545

  Fly   395 SELCGNFNGFIKKKGRTIVIDPEKDKSMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFI 459
            ..|..::..:||..|.||||:|||||:|||:|||||||:|.|:.|||..||||.|:::||||.||
  Rat   546 QVLLQHWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFI 610

  Fly   460 NQRANKPAELIAKYVDMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLV 524
            |:|.||||||||||||.|||:|||..|||||||.|||||::||||:|||||||||||||||||||
  Rat   611 NKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLV 675

  Fly   525 GKSASVDSEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVSI 589
            |||||||:|||||||||.|||..|||||||||||||||:||.|.|:.: :.|.....|::|.|:|
  Rat   676 GKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQY-MQNQNVPGNIELTVNI 739

  Fly   590 LTMGYWPTYAPTEVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGPKELLVS 654
            |||||||||.|.||.:||:.:..|:||..|||.||||||||||.|||:|:|:|:|..|.|||.||
  Rat   740 LTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVS 804

  Fly   655 LFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACGRARVITKTPKGREILDGDQFDFN 719
            |||.||||:||:....|.|||..||.||||||||||||||||:|||:.|.|||::|.|||:|..|
  Rat   805 LFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICN 869

  Fly   720 NEFTNKLFRIKINQIQMKETNEEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITELFNQ 784
            ::|.:|||||||||||||||.|||.:|.||||||||||||||||||||||||||||||::|::||
  Rat   870 DDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQ 934

  Fly   785 LTFPVKPADLKKRIESLIDRDYMERDKDNQNQYNYVA 821
            |.|||||||||||||||||||||||||:|.|||||:|
  Rat   935 LKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_610352.2	Cullin	124..722	CDD:459983	385/597 (64%)
		Cullin_Nedd8	753..813	CDD:463146	54/59 (92%)
Cul4b	NP_001100421.1	Cullin	275..872	CDD:459983	385/599 (64%)
		Cullin_Nedd8	903..963	CDD:463146	54/59 (92%)