DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul4 and Cul1

DIOPT Version :9

Sequence 1:	NP_001163084.1	Gene:	Cul4 / 35780	FlyBaseID:	FBgn0033260	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_001342479.1	Gene:	Cul1 / 26965	MGIID:	1349658	Length:	776	Species:	Mus musculus

Alignment Length:	813	Identity:	243/813 - (29%)
Similarity:	391/813 - (48%)	Gaps:	116/813 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 MGAIHNSKPGDVKKIVIKNFKD--KPTLPDNYSKDTYVKLEEAVIAIQLSKPIKYSLEELYQAVV 150
            |.:..:..|..:|:|.:....|  :..:...|::.:..|             .:|.  |||..|.
Mouse     1 MSSNRSQNPHGLKQIGLDQIWDDLRAGIQQVYTRQSMAK-------------SRYM--ELYTHVY 50

  Fly   151 NMCS--HK-------------------------MDAQLYAKLKELTEQHVKRNIKLKELTGGSMD 188
            |.|:  |:                         :..:||.:|||..:.::...:|..|   ..||
Mouse    51 NYCTSVHQSNQARGAGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGE---DLMD 112

  Fly   189 KLILLEKINHWWLSFCQQMIMIRSIFLYMDRTYVLQ-----NSTVHSIWDMGL-----DLFRIHF 243
            :.: |:.....|..:.....::..|..|::|.:|.:     ...::.|:.:.|     .|||
Mouse   113 ESV-LKFYTQQWEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFR--- 173

  Fly   244 AQNSVVQKRTVDGLLTLIEKERQGSTVDRGLLKSLVRMLCD--------------LQIYTSSFEE 294
                .:.|:..:.:|.||||||.|.|::..|:..:|:...:              |.:|..|||.
Mouse   174 ----PLNKQVTNAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFES 234

  Fly   295 KFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENERLRHYLDSSTKHPLIYNVEKELLAEH 359
            :||..|.:.|..||...:|:..|.||::....||.||..|::.||..||:..|....|:.|:.:|
Mouse   235 QFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKH 299

  Fly   360 LTSILQKGLDSLLEDNRLSDLTLLYGLLSRVKNGTSELCGNFN--------GFIKKKGRTIVIDP 416
            | .|......:||:.::..||..:|.|:||:::|..||.....        ..|:|.|...:.||
Mouse   300 L-EIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDP 363

  Fly   417 EKDKSMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFIN--------QRANKPAELIAKY 473
               |..||.:||...|.:.:|.:.|.::..|..:|.:|...|||        |.::|..||:|:|
Mouse   364 ---KMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARY 425

  Fly   474 VDMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDSEKSMLS 538
            .|..|:..:|...:.|||.||:::||:|::|..||||:.||.|.|||||:...|||.|:|.||:|
Mouse   426 CDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMIS 490

  Fly   539 KLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVSILTMGYWPTYAPTEV 603
            ||||.||..:||||:.||:|:.:|:|:|..|:.| |:|:..: :||..:.:|:.|.||.......
Mouse   491 KLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKH-LTNSEPL-DLDFSIQVLSSGSWPFQQSCTF 553

  Fly   604 TMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGPKELLVSLFQALVLLLFNDKP 668
            .:|.:.....|.|..||..:||||||.|...|....|..........|..|.||..:||.:|.:.
Mouse   554 ALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTED 618

  Fly   669 VLSYEEILAATLIEDGELRRTLQSLACGRARVITKTPKGREILDGDQFDFNNE--------FTNK 725
            ..:.:::..:|.|:...|.:.||.|...:..|:..     |..:.|:.:...:        :.||
Mouse   619 AYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLED-----ENANVDEVELKPDTLIKLYLGYKNK 678

  Fly   726 LFRIKINQIQMKETNEEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITELFNQLTFPVK 790
            ..|:.||.....|..:||:.|.:.:.:||:..|.|||||||||||.|.|..|:.|:..||:...|
Mouse   679 KLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFK 743

  Fly   791 P--ADLKKRIESLIDRDYMERDKDNQNQYNYVA 821
            |  ..:||.|:.||:::|:||....::.|:|:|
Mouse   744 PRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_001163084.1	Cullin	124..721	CDD:279260	195/663 (29%)
		CULLIN	503..644	CDD:214545	61/140 (44%)
		Cullin_Nedd8	750..815	CDD:214883	30/66 (45%)
Cul1	NP_001342479.1	Cullin	21..660	CDD:395716	196/675 (29%)
Cul1	NP_001342479.1	Cullin_Nedd8	706..767	CDD:402267	30/60 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830