DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul4 and Cul3

DIOPT Version :9

Sequence 1:	NP_001163084.1	Gene:	Cul4 / 35780	FlyBaseID:	FBgn0033260	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_057925.1	Gene:	Cul3 / 26554	MGIID:	1347360	Length:	768	Species:	Mus musculus

Alignment Length:	784	Identity:	296/784 - (37%)
Similarity:	450/784 - (57%)	Gaps:	61/784 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 SNLLNRMGAIHNSKPGDVKKIVIKNFKDKPTLPDNYSKDTYVKLEEAVIAIQLSKPIKYSLEELY 146
            |||....|:..::      |:.|:.|  ..|:.:.|....:..|:.|:..||.......|.||||
Mouse     2 SNLSKGTGSRKDT------KMRIRAF--PMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELY 58

  Fly   147 QAVVNMCSHKMDAQLYAKLKELTEQHVKRNIK---LKELTGGSMDKLILLEKINHWWLSFCQQMI 208
            :....|..||...:||..|:|:..:|:...::   |..|...      .|:.:|..|......|:
Mouse    59 RNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNN------FLQTLNQAWNDHQTAMV 117

  Fly   209 MIRSIFLYMDRTYVLQNSTVHSIWDMGLDLFRIHFAQNSVVQKRTVDGLLTLIEKERQGSTVDRG 273
            |||.|.:||||.||.||: |.:::::||.:||....:...::......||.:|.:||:|..||||
Mouse   118 MIRDILMYMDRVYVQQNN-VENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRG 181

  Fly   274 LLKSLVRMLCDL-----QIYTSSFEEKFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENE 333
            .:::..:||..|     .:|...||..||:.:.:.::.|||:.:.|.....|::.|..|:.||.|
Mouse   182 AIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIE 246

  Fly   334 RLRHYLDSSTKHPLIYNVEKELLAEHLTSILQ---KGLDSLLEDNRLSDLTLLYGLLSRVKNGTS 395
            |:.|.||.||:.|::..||:||:::|:.:|::   .||..:|::.:..||..:|.|.|||.||..
Mouse   247 RVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLK 311

  Fly   396 ELCGNFNGFIKKKGRTIVIDPEKDKS---MVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEF 457
            .:|...:.:::::|:.:|.:..:.|:   .:|.|||.|.:.|..::..|.::..|..::...||:
Mouse   312 TMCECMSCYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEY 376

  Fly   458 FINQRANKPAELIAKYVDMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRL 522
            |:|..:..| |.::.::|.||:.|.||.|::|:|..|||.||||||:..|||||.:||:.||:||
Mouse   377 FLNLNSRSP-EYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRL 440

  Fly   523 LVGKSASVDSEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCV 587
            |..||.|.||||:|:||||.|||..|||||||||:||.:|......||.|..:....:..:||.|
Mouse   441 LTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTV 505

  Fly   588 SILTMGYWPTYAPT-EVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGP--K 649
            .:||.|||||.:.| :..:||...:..:||.:|||.|||||:|..|..:|:..|.|.| .||  |
Mouse   506 RVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATF-YGPVKK 569

  Fly   650 E---------------------LLVSLFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSL 693
            |                     |.||.||..:|:|||::...::|||...|.|.:.||.|.||||
Mouse   570 EDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSL 634

  Fly   694 ACGR--ARVITKTPKGREILDGDQFDFNNEFTNKLFRIKINQIQMK--ETNEEQKATEERVFQDR 754
            |||:  .||:||.||.:||..|..|..|::||:||.|:||..:..|  |::.|:|.|.::|..||
Mouse   635 ACGKPTQRVLTKEPKSKEIESGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDR 699

  Fly   755 QYQIDAAIVRIMKMRKTLSHNLLITELFNQL--TFPVKPADLKKRIESLIDRDYMERDKDNQNQY 817
            :::|:||||||||.||.:.||:|:.|:..||  .|...|..:|||||.||:|:|:.|..:::..|
Mouse   700 KHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVY 764

  Fly   818 NYVA 821
            .|||
Mouse   765 TYVA 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_001163084.1	Cullin	124..721	CDD:279260	239/636 (38%)
		CULLIN	503..644	CDD:214545	71/141 (50%)
		Cullin_Nedd8	750..815	CDD:214883	32/66 (48%)
Cul3	NP_057925.1	Interaction with KLHL18. /evidence=ECO:0000250\|UniProtKB:Q13618	2..41		10/46 (22%)
		Cullin	35..664	CDD:279260	239/637 (38%)
		CULLIN	421..563	CDD:214545	71/141 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	677..698		6/20 (30%)
		Cullin_Nedd8	700..760	CDD:287520	29/59 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820