Protein Alignment Cul4 and Cul3

DIOPT Version :10

• Sequence 1: NP_610352.2
• Gene: Cul4 / 35780
• FlyBaseID: FBgn0033260
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: NP_057925.1
• Gene: Cul3 / 26554
• MGIID: 1347360
• Length: 768
• Species: Mus musculus
• Alignment Length: 784
• Identity: 296/784 - (37%)
• Similarity: 450/784 - (57%)
• Gaps: 61/784 - (7%)

  Fly    82 SNLLNRMGAIHNSKPGDVKKIVIKNFKDKPTLPDNYSKDTYVKLEEAVIAIQLSKPIKYSLEELY 146
            |||....|:..::      |:.|:.|  ..|:.:.|....:..|:.|:..||.......|.||||
Mouse     2 SNLSKGTGSRKDT------KMRIRAF--PMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELY 58

  Fly   147 QAVVNMCSHKMDAQLYAKLKELTEQHVKRNIK---LKELTGGSMDKLILLEKINHWWLSFCQQMI 208
            :....|..||...:||..|:|:..:|:...::   |..|...      .|:.:|..|......|:
Mouse    59 RNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNN------FLQTLNQAWNDHQTAMV 117

  Fly   209 MIRSIFLYMDRTYVLQNSTVHSIWDMGLDLFRIHFAQNSVVQKRTVDGLLTLIEKERQGSTVDRG 273
            |||.|.:||||.||.||: |.:::::||.:||....:...::......||.:|.:||:|..||||
Mouse   118 MIRDILMYMDRVYVQQNN-VENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRG 181

  Fly   274 LLKSLVRMLCDL-----QIYTSSFEEKFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENE 333
            .:::..:||..|     .:|...||..||:.:.:.::.|||:.:.|.....|::.|..|:.||.|
Mouse   182 AIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIE 246

  Fly   334 RLRHYLDSSTKHPLIYNVEKELLAEHLTSILQ---KGLDSLLEDNRLSDLTLLYGLLSRVKNGTS 395
            |:.|.||.||:.|::..||:||:::|:.:|::   .||..:|::.:..||..:|.|.|||.||..
Mouse   247 RVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLK 311

  Fly   396 ELCGNFNGFIKKKGRTIVIDPEKDKS---MVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEF 457
            .:|...:.:::::|:.:|.:..:.|:   .:|.|||.|.:.|..::..|.::..|..::...||:
Mouse   312 TMCECMSCYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEY 376

  Fly   458 FINQRANKPAELIAKYVDMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRL 522
            |:|..:..| |.::.::|.||:.|.||.|::|:|..|||.||||||:..|||||.:||:.||:||
Mouse   377 FLNLNSRSP-EYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRL 440

  Fly   523 LVGKSASVDSEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCV 587
            |..||.|.||||:|:||||.|||..|||||||||:||.:|......||.|..:....:..:||.|
Mouse   441 LTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTV 505

  Fly   588 SILTMGYWPTYAPT-EVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGP--K 649
            .:||.|||||.:.| :..:||...:..:||.:|||.|||||:|..|..:|:..|.|.| .||  |
Mouse   506 RVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATF-YGPVKK 569

  Fly   650 E---------------------LLVSLFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSL 693
            |                     |.||.||..:|:|||::...::|||...|.|.:.||.|.||||
Mouse   570 EDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSL 634

  Fly   694 ACGR--ARVITKTPKGREILDGDQFDFNNEFTNKLFRIKINQIQMK--ETNEEQKATEERVFQDR 754
            |||:  .||:||.||.:||..|..|..|::||:||.|:||..:..|  |::.|:|.|.::|..||
Mouse   635 ACGKPTQRVLTKEPKSKEIESGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDR 699

  Fly   755 QYQIDAAIVRIMKMRKTLSHNLLITELFNQL--TFPVKPADLKKRIESLIDRDYMERDKDNQNQY 817
            :::|:||||||||.||.:.||:|:.|:..||  .|...|..:|||||.||:|:|:.|..:::..|
Mouse   700 KHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVY 764

  Fly   818 NYVA 821
            .|||
Mouse   765 TYVA 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_610352.2	Cullin	124..722	CDD:459983	239/637 (38%)
		Cullin_Nedd8	753..813	CDD:463146	31/61 (51%)
Cul3	NP_057925.1	Interaction with KLHL18. /evidence=ECO:0000250|UniProtKB:Q13618	2..41		10/46 (22%)
		Cullin	34..665	CDD:459983	239/639 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	677..698		6/20 (30%)
		Cullin_Nedd8	698..760	CDD:463146	31/61 (51%)