Protein Alignment Cul4 and cul-5

DIOPT Version :9

• Sequence 1: NP_001163084.1
• Gene: Cul4 / 35780
• FlyBaseID: FBgn0033260
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: NP_505616.2
• Gene: cul-5 / 179413
• WormBaseID: WBGene00000840
• Length: 765
• Species: Caenorhabditis elegans
• Alignment Length: 799
• Identity: 211/799 - (26%)
• Similarity: 375/799 - (46%)
• Gaps: 159/799 - (19%)

  Fly   137 PIKYSL-----------EELYQAVVNMCSHKMDAQLYAKLKELTEQHV-----KRNIKLKEL-TG 184
            ||.::|           ::|:..|..:.|...|..|  |::::..:.:     :.|.:::.| |.
 Worm    12 PIVHALLHQKSVTPAAWQDLFYHVYKITSWVDDGPL--KIRDILTRCINDYVHEANKRIRSLQTD 74

  Fly   185 GSMDKLILLEKINHWWLSFCQQMIMIRSIFLYMD----------------RTYVLQNSTVHSIWD 233
            ||    :|:..|.. |..|.||..::...|..:|                ||.:|:.      |:
 Worm    75 GS----LLIGYIKE-WNRFYQQANILPLPFKKIDESSRRRSVPETPEESIRTVMLEK------WN 128

  Fly   234 MGLDLFRIHFAQNSVVQKRTVDGLLTLIEKERQGSTVDR----GLLKSLVRMLCD------LQIY 288
               ::..::.::..:|:      .|.|:::||.|:.:|.    |:.:|.| .|.|      |.:|
 Worm   129 ---EIIFMNISEQLLVE------ALRLVKEERDGNIIDAQNVIGIRESFV-ALNDRAGEDPLLVY 183

  Fly   289 TSSFEEKFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENERLRHYLD----SSTKH---- 345
            ..|||.:|::.|.:.||......:.||.|.||:.:.:|:|.||.:|.:.||:    :|.||
 Worm   184 RQSFERQFIEQTTEYYKKICGNLLNELGVLEYMVYADKKLEEEQQRAKRYLEMNSPTSGKHMEKA 248

  Fly   346 --PLIYNVEKELLAEHLTSILQKGLDSLLEDNRLSDLTLLYGLLSRVKNGTSELCGNFNGFIKKK 408
              .|:.:.|..:|||....|..|.::.|..         ||.|:.|.::|...:....:..|:.:
 Worm   249 VIALVESFEDTILAECSKLIASKDVERLQR---------LYRLIRRTRSGIDTVLKCIDTHIRTE 304

  Fly   409 G--------RTIVIDPEKDKSMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFINQRA-- 463
            |        ..:..|||:   .||.||...||...:||..|..:.:...:..:||...:|..:
 Worm   305 GLNDMRNNAENLSTDPER---YVQQLLLMFDKFSSLVREGFCDDARLLTARDKAFRAVVNDSSIF 366

  Fly   464 ---------------NKPAELIAKYVDMKLRSG--NKGTTDEELEKTLDKIMVLFRFIHGKDVFE 511
                           :|.|||:|.|.|:.||..  :|..|.||:::.|::::::.:::..||||.
 Worm   367 KTEMMNKKGRTLSVESKCAELLANYCDLLLRKTQLSKKLTSEEIDEKLNQVLLVLKYVENKDVFM 431

  Fly   512 AFYKKDLAKRLLVGKSASVDSEKSMLSKLKQECG--GGFTSKLEGMFKDMELSRDINIAFRGHAL 574
            .|::..|::||::..||..:.|:.|::||: |||  ....:||..|.:|:||::|:|.:|: .||
 Worm   432 RFHRAHLSRRLILEMSADQEKEEMMVTKLR-ECGMPSDAVNKLSRMLQDIELNKDMNSSFK-KAL 494

  Fly   575 ---SNNRDVHNLDLCVSILTMGYWPTYAPTEVTMPPQFINPQQI------FNKFYLEKHSGRKLQ 630
               :||:.:.: .:.:.:|..|.|.......:    :|..|:::      ...||.::|:||||.
 Worm   495 TGTNNNKSIAD-SINMKVLNGGAWGRGGSERI----RFSLPRELEDFVPEMEAFYKKQHNGRKLC 554

  Fly   631 WQPTLGN-CMLRAQFDAGPKELLVSLFQALVLLLFNDK--PVLSYEEILAATLIEDGELRRTLQS 692
            |.....: .|:....:.|..:|..:.||..||..|||:  ..:|.|.:..||.:.|.||.|||.|
 Worm   555 WMHHWSSGTMVFGTANGGRFDLECTTFQMAVLFCFNDRAHDKISLETLRLATELPDAELNRTLLS 619

  Fly   693 L-ACGRAR-------VITKTPKGREILDGDQFDFNNEFT-----NKLFRIKIN---QIQMK-ETN 740
            | |..:.|       |.:.|...|:..|..:|..|::|.     ....|.|:|   ::|:. |.|
 Worm   620 LVAYPKMRYQILLCDVPSTTVTARDFTDSTKFLINHDFNVVKNGKSQQRGKVNLIGRLQLSLEAN 684

  Fly   741 EEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLL---ITELFNQLTFPVKPADLKKRIESLI 802
            .|::  .|.:...|:.::...||:|:|.|||.:...|   :.|:...|..|.:.. :|::|:.||
 Worm   685 AEKE--HESIVALRELRVQEGIVKILKTRKTYTLAQLTMELVEILKPLFIPNRKI-IKEQIDWLI 746

  Fly   803 DRDYMERDKDNQNQYNYVA 821
            :..||||..|:.|.:.|::
 Worm   747 ENKYMERRADDINTFVYIS 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_001163084.1	Cullin	124..721	CDD:279260	179/685 (26%)
		CULLIN	503..644	CDD:214545	44/152 (29%)
		Cullin_Nedd8	750..815	CDD:214883	21/67 (31%)
cul-5	NP_505616.2	Cullin	18..656	CDD:279260	176/679 (26%)
		CULLIN	423..562	CDD:214545	43/145 (30%)
		Cullin_Nedd8	692..759	CDD:214883	21/67 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820