Protein Alignment Cul4 and cul-3

DIOPT Version :10

• Sequence 1: NP_610352.2
• Gene: Cul4 / 35780
• FlyBaseID: FBgn0033260
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: NP_503151.1
• Gene: cul-3 / 178547
• WormBaseID: WBGene00000838
• Length: 777
• Species: Caenorhabditis elegans
• Alignment Length: 777
• Identity: 254/777 - (32%)
• Similarity: 415/777 - (53%)
• Gaps: 59/777 - (7%)

  Fly    97 GDVKKIVIKNFKDKPTLPDNYSKDTYVKLEEAVIAIQLSKPIKYSLEELYQAVVNMCSHKMDAQL 161
            |..:|:.|:.|  ..|:.:.|...|:..|:.|:..||.......|.||||:....|..||...:|
 Worm     8 GGQQKMRIRPF--MATIDEQYVTQTWELLKRAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGERL 70

  Fly   162 YAKLKELTEQHVKRNIKLKELTGGSMDKLILLEKINHWWLSFCQQMIMIRSIFLYMDRTYVLQNS 226
            |..||::.:.|: .:::::.:.  ||:....||.:...|......|:|||.|.:||||.||.||:
 Worm    71 YNGLKDVIQDHM-ASVRIRIIE--SMNSGSFLETVAESWADHTVAMVMIRDILMYMDRIYVAQNN 132

  Fly   227 TVHSIWDMGLDLFRIHFAQNSVVQKRTVDGLLTLIEKERQGSTVDRGLLKSLVRMLCDL-----Q 286
            .|..::::|||.:|....:.:.:..|..|.||.||:.:|:.:.::...:|:...||..|     .
 Worm   133 HVLPVYNLGLDAYRTEILRQNGIGDRIRDALLELIKLDRKSNQINWHGIKNACDMLISLGIDSRT 197

  Fly   287 IYTSSFEEKFLDATNQLYKAESQRKMQ-ELEVPEYLQHVNKRLAEENERLRHYLDSSTKHPLIYN 350
            :|...||...|..|:..|:...:..:. :.:...||..|...:.:|..|...|||..|:..::..
 Worm   198 VYEDEFERPLLKETSDYYRDVCKNWLSGDNDACFYLAQVEIAMHDEASRASRYLDKMTEAKILQV 262

  Fly   351 VEKELLAEHLTSIL---QKGLDSLLEDNRLSDLTLLYGLLSRVKN-------GTSELCGNFNGFI 405
            ::..::|||:.:|:   ..|:..:||..::.|||.::.:..|:.:       |...|....:.::
 Worm   263 MDDVMVAEHIQTIVYMQNGGVKFMLEHKKIEDLTRIFRIFKRIGDSVTVPGGGLKALLKAVSEYL 327

  Fly   406 KKKGRTIVIDPEKDK---SMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFINQRANKPA 467
            .:.|..||.:.:..|   :.|.:||..||....::.|.|..:..|.|..:..||.|:|.....|
 Worm   328 NETGSNIVKNEDLLKNPVNFVNELLQLKDYFSSLLTTAFADDRDFKNRFQHDFETFLNSNRQSP- 391

  Fly   468 ELIAKYVDMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDS 532
            |.:|.|:|..||||.|..:|.|::..||.:|:|||::..|||||.::|:.||||||:.||.|.|.
 Worm   392 EFVALYMDDMLRSGLKCVSDAEMDNKLDNVMILFRYLQEKDVFEKYFKQYLAKRLLLDKSCSDDV 456

  Fly   533 EKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVSILTMGYWPT 597
            ||::|:|||.|||..||.|||.||:|.||...:..:||....:....: ::|:.:.:||.|.|||
 Worm   457 EKALLAKLKTECGCQFTQKLENMFRDKELWLTLATSFRDWREAQPTKM-SIDISLRVLTAGVWPT 520

  Fly   598 YAPTEVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQF-----------DAGP--- 648
            .....|.:|.:.....::|.::|.|||:||||.....|||..::|.|           :.||
 Worm   521 VQCNPVVLPQELSVAYEMFTQYYTEKHTGRKLTINTLLGNADVKATFYPPPKASMSNEENGPGPS 585

  Fly   649 -------------KELLVSLFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACGRA-- 698
                         |.|.|:..|.::||.||....:|.::::....|.:.||:|.|||||.|:|
 Worm   586 SSGESMKERKPEHKILQVNTHQMIILLQFNHHNRISCQQLMDELKIPERELKRNLQSLALGKASQ 650

  Fly   699 RVITKTPKGREILD-GDQFDFNNEFTNKLFRIKINQIQMK-ETNEEQKATEERVFQDRQYQIDAA 761
            |::.:..||::.:| .|:|..|:.|.:||.|:|:..:..| |:..|.:.|.::|..||:.:::||
 Worm   651 RILVRKNKGKDAIDMSDEFAVNDNFQSKLTRVKVQMVTGKVESEPEIRETRQKVEDDRKLEVEAA 715

  Fly   762 IVRIMKMRKTLSHNLLITELFNQL--TFPVKPADLKKRIESLIDRDYMERDKDNQNQYNYVA 821
            ||||||.||.|:||.|:.|:..||  .|...|..:|:|||:||:|:|:.||:.:...|.|:|
 Worm   716 IVRIMKARKKLNHNNLVAEVTQQLRHRFMPSPIIIKQRIETLIEREYLARDEHDHRAYQYIA 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_610352.2	Cullin	124..722	CDD:459983	203/646 (31%)
		Cullin_Nedd8	753..813	CDD:463146	31/61 (51%)
cul-3	NP_503151.1	Cullin	31..675	CDD:459983	203/648 (31%)
		Cullin_Nedd8	707..769	CDD:463146	31/61 (51%)