Protein Alignment Cul4 and Cul1

DIOPT Version :10

• Sequence 1: NP_610352.2
• Gene: Cul4 / 35780
• FlyBaseID: FBgn0033260
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: XP_061518789.1
• Gene: Cul1 / 1277942
• VectorBaseID: AGAMI1_005719
• Length: 778
• Species: Anopheles gambiae
• Alignment Length: 791
• Identity: 250/791 - (31%)
• Similarity: 390/791 - (49%)
• Gaps: 119/791 - (15%)

  Fly   123 VKLEEAVIAIQLSKPIK--YSLE---------ELYQAVVNMCS--HK------------------ 156
            :.|||  |...|...||  |..|         |||..|.|.|:  |:
Mosquito    15 INLEE--IWTDLEAGIKQVYKRELSLGIARYMELYTHVYNYCTSVHQQPNSRTGSSKISKKGISA 77

  Fly   157 -------MDAQLYAKLKELTEQHVKRNIKLKELTGGSMDKLILLEKINHW-WLSFCQQMIMIRSI 213
                   :..:||.:|||..|.::   ::|.:.....||:.:|......| ...|..:  ::..:
Mosquito    78 PPGGAQLVGQELYKRLKEFLENYL---VRLHQNGIDLMDEEVLSFYTKRWEEYQFSSK--VLNGV 137

  Fly   214 FLYMDRTYVLQ-----NSTVHSIWDMGLDLFRIHFAQNSVVQKRTVDGLLTLIEKERQGSTVDRG 273
            ..|::|.:|.:     ...|:.|:.:.|..:|.:..::  :.|:..:.:|.|||:||.|.|::..
Mosquito   138 CAYLNRHWVKRECEEGRKDVYEIYQLALVTWRGNLFKH--LNKQVTNAVLKLIERERNGETINSR 200

  Fly   274 LLKSLVRMLCD--------------LQIYTSSFEEKFLDATNQLYKAESQRKMQELEVPEYLQHV 324
            |:..::....:              |.:|..|||..||:.|.:.|..||...::|..|.||::.|
Mosquito   201 LVSGVINCYVELGLNEDDPHAKGQNLSVYKESFENIFLEDTERFYTRESAEFLRENPVTEYMKRV 265

  Fly   325 NKRLAEENERLRHYLDSSTKHPLIYNVEKELLAEHLTSILQKGLDSLLEDNRLSDLTLLYGLLSR 389
            ..||.||.:|::.||..||...|....|:.|:..||.. .:....:||..::..||..:|.|::|
Mosquito   266 ELRLNEEQKRVQVYLHESTLDRLAEKCERVLIHIHLDQ-FRTEFQNLLNSDKNQDLGRMYSLVAR 329

  Fly   390 VKNGTSELCGNFN--------GFIKKKGRTIVIDPEKDKSMVQDLLDFKDKMDVIVRTCFEHNEK 446
            :|.|..||.....        ..|:|.|.:.|.||   |..||.:|:...|.:.:|.|.|.::..
Mosquito   330 IKAGLYELKEILETHIHNQGLAAIEKCGDSAVNDP---KIYVQTILEVHKKYNALVLTAFNNDSG 391

  Fly   447 FTNSLREAFEFFIN--------QRANKPAELIAKYVDMKLRSGNKGTTDEELEKTLDKIMVLFRF 503
            |..:|.:|...|||        :.|:|..||:|||.|:.|:..:|...:.|||.||:::||:|::
Mosquito   392 FVAALDKACGKFINTNAVTELSRSASKSPELLAKYCDLLLKKSSKNPEEAELEDTLNQVMVVFKY 456

  Fly   504 IHGKDVFEAFYKKDLAKRLLVGKSASVDSEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIA 568
            |..||||:.||.|.|||||....|||.|:|.||:|||||.||..:||||:.||:|:.:|:|:|..
Mosquito   457 IEDKDVFQKFYSKMLAKRLCQHMSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNDQ 521

  Fly   569 FRGH--ALSNNRDV--HNLDLCVSILTMGYWPTYAPTEVTMPPQFINPQQIFNKFYLEKHSGRKL 629
            :|.|  .|.:.|..  :.:|..:.:|:.|.||.......::|.:.......||.||.::||||||
Mosquito   522 YRKHHEKLRDTRSTTQNEIDFSILVLSSGSWPFGQGFTFSLPFELEQSVHRFNNFYAKQHSGRKL 586

  Fly   630 QW------QPTLGNCMLRAQFDAGPKELLVSLFQALVLLLFNDKPVLSYEEILAATLIEDGELRR 688
            .|      ...:.|| .|.::     .|..|.||..|||.||::...|.:::...|.|.:..|.:
Mosquito   587 NWLYNMCRGELITNC-FRMRY-----TLQASTFQMAVLLQFNEETAWSIKQLGENTGINNENLIQ 645

  Fly   689 TLQSLACGRARVITKTP-----KGREILDGDQ-FDFNNEFTNKLFRIKINQIQMKETNEEQKATE 747
            .|.        ::.||.     :|...|..|. .:.|.:|.|:..||.||.....|...||:||.
Mosquito   646 VLP--------ILLKTKLLNCYEGEGKLHPDSTIELNKDFKNRKLRININFPLKSELKVEQEATH 702

  Fly   748 ERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITELFNQLTFPVKP--ADLKKRIESLIDRDYMERD 810
            :.:.:||:..|.|||||||||||.|:|..|:.|:.|||:...||  ..:||.|:.||:::|:||.
Mosquito   703 KNIEEDRKILIQAAIVRIMKMRKMLNHTQLVNEVLNQLSTRFKPKIQVIKKCIDILIEKEYLERQ 767

  Fly   811 KDNQNQYNYVA 821
            :..::.|:|:|
Mosquito   768 EGQKDTYSYLA 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_610352.2	Cullin	124..722	CDD:459983	205/687 (30%)
		Cullin_Nedd8	753..813	CDD:463146	31/61 (51%)
Cul1	XP_061518789.1	None