Protein Alignment Cul4 and cul2

DIOPT Version :10

• Sequence 1: NP_610352.2
• Gene: Cul4 / 35780
• FlyBaseID: FBgn0033260
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: XP_002935209.2
• Gene: cul2 / 100492608
• XenbaseID: XB-GENE-960931
• Length: 766
• Species: Xenopus tropicalis
• Alignment Length: 789
• Identity: 224/789 - (28%)
• Similarity: 381/789 - (48%)
• Gaps: 109/789 - (13%)

  Fly    99 VKKIVIKNFKDKPTLPDNYSKDTYVKLEEAVIAIQLSKPIKYSLEELYQAVVNMCSHKMDAQLYA 163
            :|.:|:.::.::.|..|.:| |.|      .:.:...:|                   :..:||.
 Frog    21 IKAVVMLDYVERATWNDRFS-DIY------ALCVAYPEP-------------------LGERLYT 59

  Fly   164 KLKELTEQHVKRNIKLKELTGGSMDKLILLEKINHWWLSFCQQMIMIRSIFLYMDRTYVLQNSTV 228
            :.|...|.||:   :|......|.::::::  ...:|..:.:....:..::.|::..|:.:|...
 Frog    60 ETKIFLENHVQ---QLHTRVLDSAEQVLVM--YYRYWEEYSRGADYMDCLYRYLNTQYIKKNKLT 119

  Fly   229 HS-----------------IWDMGLDLFR---IHFAQNSVVQKRTVDGLLTLIEKERQG----ST 269
            .:                 |.::.|||:|   |...|:::::.     ||..|:::|.|    ..
 Frog   120 EADLQYGYGGVDMNEPLMEIGELALDLWRKLMIEPLQDTLLRM-----LLKEIKRDRCGEDPNQK 179

  Fly   270 VDRGLLKSLV-----RMLCDLQIYTSSFEEKFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLA 329
            |..|::.|.|     :....|:.|...||..||..|.:.||.|:...:||....:|::.:..||.
 Frog   180 VIHGVINSFVHVEQYKKKFPLKFYQEIFELPFLAETGEYYKQEASNLLQESNCSQYMEKILGRLK 244

  Fly   330 EENERLRHYLDSSTKHPLIYNVEKELLAEHLTSILQKGLDSLLEDNRLSDLTLLYGLLSRVKNGT 394
            :|..|.|.||..|:.:.:|:..::.::|:|| ..|.....:::...|.||:..:|.||..|.||.
 Frog   245 DEEIRCRKYLHPSSYNKVIHECQQRMVADHL-QFLHAECHNIIRQERRSDMANMYTLLRAVSNGL 308

  Fly   395 SELCGNFNGFIKKKGRTIVIDPEKDK---SMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFE 456
            ..:.......|..:|...:.:..::.   ..|:.:|:...|...:|.:....::.|.::|.:|..
 Frog   309 PHMIQELQNHIHDEGLRAISNLSQENMPTQFVESVLEVHSKFVQLVNSVLNGDQHFMSALDKALT 373

  Fly   457 FFINQRANKPA----ELIAKYVDMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKD 517
            ..:|.|..|..    ||:|||.|..|:...||.|:.|:|..|...:.:|::|..||||:.||.:.
 Frog   374 CVVNYREPKSVCKAPELLAKYCDNMLKKSAKGMTENEVEDKLTSFITVFKYIDDKDVFQKFYARM 438

  Fly   518 LAKRLLVGKSASVDSEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHN 582
            |||||:.|.|.|:|||::|::||||.||..|||||..|:.||.:|.|:|..|..  ...|:|. .
 Frog   439 LAKRLIHGLSMSMDSEETMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNN--FIKNQDT-V 500

  Fly   583 LDLCVS----ILTMGYWP-TYAPTEVTMPPQFINPQ-QIFNKFYLEKHSGRKLQWQPTLGNCMLR 641
            :||.:|    :|..|.|| |.||:.....||.:... |:|..||.:..|||||.|...|....::
 Frog   501 IDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYNQHFSGRKLTWLHYLCTGEVK 565

  Fly   642 AQFDAGPKELLVSLFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACGRARVITKTPK 706
            ..:...|...:|:.:|..|||.||:..:::|:|:..:|.:.:.||.:|::||.  ..::|.. ..
 Frog   566 MNYLCKPYVAMVTTYQMAVLLAFNNSEIVTYKELQDSTQMNEKELTKTIKSLL--DVKMINH-DS 627

  Fly   707 GREILDGDQ-FDFNNEFTNKLFRIKINQIQMKETNE---------------------EQKATEER 749
            .:|.:||:. |..|..|::|..:.||.....|:|.:                     |.:.|...
 Frog   628 DKEDIDGESTFSLNMNFSSKRTKFKITTPMQKDTPQGAQPTCAEEAMLWRGERRFSLEVEQTRSA 692

  Fly   750 VFQDRQYQIDAAIVRIMKMRKTLSHNLLITELFNQLTFPVKP--ADLKKRIESLIDRDYMERDKD 812
            |.:||:..:.||||||||.||.|.||.||.|:.:|......|  :.:||.||.|||:.|:||.:.
 Frog   693 VDEDRKMYLQAAIVRIMKARKILRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQA 757

  Fly   813 NQNQYNYVA 821
            :.::|:|||
 Frog   758 SADEYSYVA 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_610352.2	Cullin	124..722	CDD:459983	174/640 (27%)
		Cullin_Nedd8	753..813	CDD:463146	30/61 (49%)
cul2	XP_002935209.2	Cullin	14..644	CDD:459983	181/665 (27%)
		Cullin_Nedd8	696..756	CDD:463146	30/59 (51%)