DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tmem63 and TMEM63A

DIOPT Version :9

Sequence 1:	NP_610351.1	Gene:	Tmem63 / 35779	FlyBaseID:	FBgn0033259	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_055513.2	Gene:	TMEM63A / 9725	HGNCID:	29118	Length:	807	Species:	Homo sapiens

Alignment Length:	818	Identity:	258/818 - (31%)
Similarity:	425/818 - (51%)	Gaps:	98/818 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MSENSNISYC-QAVANRTSFFTTAYNGIPETLILNTIFWVLLILLFTVLRHQAGDFGRLALVNSN 66
            :.:..|.||| .:..|.|......:.|||..|:::...::.|||:|:::|.:..|:||:|||:..
Human    23 LGDRPNDSYCYNSAKNSTVLQGVTFGGIPTVLLIDVSCFLFLILVFSIIRRRFWDYGRIALVSEA 87

  Fly    67 GSKKRWTEIFYSRAASVVDPQPSTSTQVSPRPSTTSQGVPDSTPLSPIQPEEGLFGWIRVTLKLR 131
            .|:.|:..:                      .||:|.|..|      .:.|.|...|:....:|.
Human    88 DSESRFQRL----------------------SSTSSSGQQD------FENELGCCPWLTAIFRLH 124

  Fly   132 KETILLHTGPDAVHYLSFQQHLMAVMALVTIVSLVIILPVNFLNGP--KENPYDVNAFGRTTMAN 194
            .:.||...|.||:||||||:|::.::.:|:.:||.:||||| |:|.  .::||   :|||||:||
Human   125 DDQILEWCGEDAIHYLSFQRHIIFLLVVVSFLSLCVILPVN-LSGDLLDKDPY---SFGRTTIAN 185

  Fly   195 LSPDSPWLWVHTIITILYIPLVVLIMRRASGRNAFKK--AATRTIMISNISSSDRNKTVVRNYMQ 257
            |..|:..||:|||..::|:.|.|..||..:....:|:  ...||:.|:.: ..|..|..|.::.:
Human   186 LQTDNDLLWLHTIFAVIYLFLTVGFMRHHTQSIKYKEENLVRRTLFITGL-PRDARKETVESHFR 249

  Fly   258 ELFPDVTIENVSIAYNISRLYVRNAEFERVHEARLYCEHHR----NRDTLMVKP-------EMCS 311
            :.:|...:.:|.:.||:::|.....|.::..::..|..:.:    .|..:..||       |:..
Human   250 DAYPTCEVVDVQLCYNVAKLIYLCKEKKKTEKSLTYYTNLQVKTGQRTLINPKPCGQFCCCEVLG 314

  Fly   312 CKKENAYEYYQREERKLSGDVARLRASTMNEPLDIAFITVSTVQEAQNIVTHFT----------- 365
            |:.|:|..||.|.:.:|...:........::||.:||:|......|..|:..|.
Human   315 CEWEDAISYYTRMKDRLLERITEEERHVQDQPLGMAFVTFQEKSMATYILKDFNACKCQSLQCKG 379

  Fly   366 ---PGTY------RQWHLVFAPSPDDLFWENLNVNKSHWYLKFFCVNAVLFLVLFFLSTPAMVVS 421
               |.::      .:|.:.||..|:|:.|:||::....|:|::..:|..|||.||||:||::::|
Human   380 EPQPSSHSRELYTSKWTVTFAADPEDICWKNLSIQGLRWWLQWLGINFTLFLGLFFLTTPSIILS 444

  Fly   422 LLNSRPWVKETEGKISPLVADFLPTLMLWTLSALMPVIVAISDKWMRHYTRSKQNYSIMTKCFGY 486
            .::.....|......:|:::.|.|||:||:.|||:|.||..|.....|:|:|.:|..:|||.:.:
Human   445 TMDKFNVTKPIHALNNPIISQFFPTLLLWSFSALLPSIVYYSTLLESHWTKSGENQIMMTKVYIF 509

  Fly   487 LLMMIMILPSLGLTSAQALLEWGFLNQTD-----RWQCIFLPDRGSFYVNYIITAAFIGTALELL 546
            |:.|::|||||||||......|.| ::|.     |.:|:||||:|:|:|||:|.:||||..:|||
Human   510 LIFMVLILPSLGLTSLDFFFRWLF-DKTSSEASIRLECVFLPDQGAFFVNYVIASAFIGNGMELL 573

  Fly   547 RFPELIVYIWSLLKAKSKAETPYIRKAILIEFPFGTHYAWTTLVFTIAIVYSVACPLIMPFAMIY 611
            |.|.||:|.:.::.||:.|:...:::....::.||..|||...|||:.:.||:.||:|.||.:||
Human   574 RLPGLILYTFRMIMAKTAADRRNVKQNQAFQYEFGAMYAWMLCVFTVIVAYSITCPIIAPFGLIY 638

  Fly   612 ICLKHFVDRHNLYFAYGPSNMISRKGGKIHSTAVTMTKFSVVILVLVMAMICFFR-GDNGMA--- 672
            |.|||.||||||||.|.|:.:  .||  ||..||.....:.::.:..:....|.| |....|
Human   639 ILLKHMVDRHNLYFVYLPAKL--EKG--IHFAAVNQALAAPILCLFWLYFFSFLRLGMKAPATLF 699

  Fly   673 RFLLLIISLAITLT-----LFTFMSPIK---RCAATRRPSIVEIAGPAPI--YVPDVLKDNGIRT 727
            .||:|::::.:.|.     .|..:||:.   ...|:.:.|..|...|.|.  |||.:|.......
Human   700 TFLVLLLTILVCLAHTCFGCFKHLSPLNYKTEEPASDKGSEAEAHMPPPFTPYVPRILNGLASER 764

  Fly   728 SSVRPSAAAFGGYG-----SDSVSEYDSSQYSVNSVEA 760
            :::.|.......||     |.::.....:|.:..||.|
Human   765 TALSPQQQQQQTYGAIHNISGTIPGQCLAQSATGSVAA 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmem63	NP_610351.1	RSN1_TM	32..220	CDD:290675	64/189 (34%)
		PHM7_cyt	270..328	CDD:291375	15/68 (22%)
		RSN1_7TM	347..663	CDD:280815	128/340 (38%)
TMEM63A	NP_055513.2	RSN1_TM	52..207	CDD:316484	62/186 (33%)
		PHM7_cyt	228..410	CDD:317147	39/182 (21%)
		RSN1_7TM	439..692	CDD:308377	104/257 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E1_COG5594
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H101673
Inparanoid	1	1.050	410	1.000	Inparanoid score	I1869
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54295
OrthoDB	1	1.010	-	-		D123365at33208
OrthoFinder	1	1.000	-	-		FOG0001439
OrthoInspector	1	1.000	-	-		otm41904
orthoMCL	1	0.900	-	-		OOG6_100323
Panther	1	1.100	-	-	LDO	PTHR13018
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1690
SonicParanoid	1	1.000	-	-		X290
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870