Protein Alignment Tmem63 and RSN1

DIOPT Version :9

• Sequence 1: NP_610351.1
• Gene: Tmem63 / 35779
• FlyBaseID: FBgn0033259
• Length: 760
• Species: Drosophila melanogaster
• Sequence 2: NP_013993.1
• Gene: RSN1 / 855308
• SGDID: S000004879
• Length: 953
• Species: Saccharomyces cerevisiae
• Alignment Length: 871
• Identity: 176/871 - (20%)
• Similarity: 329/871 - (37%)
• Gaps: 214/871 - (24%)

  Fly     4 SENSNISYCQAVANRTSFFTTAYNGIPETLILN-TIFWVLLILLFTVLRHQAGDFGRLALVNSNG 67
            |.||..|...|.:..||     ...:..:|:.| |||.| .::.|.:||.:.
Yeast     3 STNSTNSTTTATSTNTS-----TQQVVTSLVSNGTIFGV-FVIAFLILRIKL------------- 48

  Fly    68 SKKRWTEIFYSRAASVVDPQPSTSTQVSPRPSTTSQGVPDSTPLSPIQPEEGLFGWIRVTLKLRK 132
              ||           :.:|:.|.:.       ...:..|:..|       :|::.|::..||...
Yeast    49 --KR-----------IYEPKSSFNL-------INEEKKPEPLP-------QGVWQWLKPLLKKSD 86

  Fly   133 ETILLHTGPDAVHYLSFQQHLMAVMALVTIVSLVIILP----VNFLNGPKENPYDVNAF------ 187
            ..::...|.|...:|.:    :.::|:...||:..|.|    :|..||..|:..:..|:
Yeast    87 NFVIQQAGLDGYFFLRY----LFIIAIYCAVSMSYIFPILLSINASNGNHESGLNQLAYQNVKHR 147

  Fly   188 GRTTMANLSPDSPWLWVHTIITILYIPLVVLIMRR----ASGRNAFKKAATRTIMISNISSSDRN 248
            || ..|::.  ..|::....:.|:|..|......:    ||.|.| ||.::||::.
Yeast   148 GR-YFAHVF--CGWIFFWGFLYIIYRELYFYTSMKQAVLASPRYA-KKLSSRTVLF--------- 199

  Fly   249 KTVVRNYMQE-----LFPDV----------TIENVSIAYNISRLYVRNAEFERVHEA-RLYCEHH 297
            :||.:.|:.|     ||..|          :||.:..|.:...:.:..||.:.:..| :...:.:
Yeast   200 QTVPKQYLSEEEFSKLFDGVKRVWIARGSGSIEAMVKARDNMAIQLEGAETKYLKAALKKIKKLN 264

  Fly   298 RNRDTLMVKPEMCSC--------------------KKENAYEYYQREERKLSGDVARLRASTMN- 341
            :....|.|...:...                    ||.:...|.:.|..||:..|..|:....|
Yeast   265 KKSPQLSVSDNIAEYVPDKKRPHHKINKVAKFFFGKKVDTISYIKEELPKLNQKVKALQEDHENS 329

  Fly   342 EPLDIAFITVSTVQEAQ---NIVTHFTPGTYRQWHLVFAP-----SPDDLFWENLNVNKSHWYLK 398
            .|.:..|:...:..:||   .|.|:..|       |...|     .|.|:.|.||   :..|:.:
Yeast   330 SPFNSVFVEFESQYQAQVAAQITTYHAP-------LFMTPVYIGIEPSDVVWFNL---RMFWWER 384

  Fly   399 F----FCVNAVLFLVLF------FLSTPAMVVSLLNSRPWVK---ETEGKISPLVADFLPTLMLW 450
            .    ..|:|::.||:.      |:...:.:.||.|...|:|   :...::..|:....||:.|.
Yeast   385 LGREVSAVSAIVALVILWAFPVAFVGMISNITSLTNEVKWLKFIYKLPKQLLGLLTSLAPTVALA 449

  Fly   451 TLSALMPVIV---AISDKWMRHYTRSKQNYSIMTK--CFGYLLMMIMILPSLGLTSAQALLEWGF 510
            .|.:.:|..:   ||:..     ..||||....|:  .|.:.::.:.::.:|...:...:.|  .
Yeast   450 VLMSFLPKFIRGMAITQG-----APSKQNVEYFTQQAYFAFQVIQVFLVTTLSSAATSTVTE--I 507

  Fly   511 LNQTDRWQCIF---LPDRGSFYVNYIITAAFIGTALELLRFPELIVY--IWSLLKAKSKAETPYI 570
            :.:..:...:.   ||...:|:::|:|......::..||:...||::  :.:.|....:.:  :.
Yeast   508 VKEPTKAMDLLASNLPKASNFFMSYVILQGLSISSGALLQIVPLILFYVLGAFLDGTVRKK--WN 570

  Fly   571 RKAILIEFPFGTHYAWTTLVFTIAIVYSVACPLIMPFAMIYICLKHFVDRHNLYFAYGPSNMISR 635
            |...|....:||.:...|.:..|...||:..|||:.||.:...|.:....:||.:.|..|   ..
Yeast   571 RFCGLSSMQWGTAFPVYTNLAVITFSYSIISPLILLFAAVAFFLLYIAYLYNLTYVYQES---PD 632

  Fly   636 KGGKIHSTAVTMTKFSVVILVLVMAMIC---FFRGDNGMARFLLLIISLAITLTLFTFMSPIKRC 697
            ..|..:..|:..|     |:.:.:..||   .|....|....:|.:|.:.:|:.:...:|    .
Yeast   633 ARGIYYPRALFQT-----IVGIYIGQICLLGLFAVGKGWGPIVLQVIGICVTVLIHLHLS----A 688

  Fly   698 AATRRPSIVEIAGPAPIYVPDVLKD--------NGIRTSSVRPSAAAFGG--------------- 739
            |......::.:....|:   |.:.|        .||.::.|:.:  .||.
Yeast   689 AFDHLSKVIPVDTMKPL---DGVSDTPSFKNIYKGIESTKVKKN--TFGANIDMDGIKELPEFPI 748

  Fly   740 ----YGSDSVSE--YDSSQYSVNSVE 759
                ..|:||:|  .::|.:|.|:.|
Yeast   749 KKYHKRSESVTEQQVENSIFSENTFE 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmem63	NP_610351.1	RSN1_TM	32..220	CDD:290675	39/198 (20%)
		PHM7_cyt	270..328	CDD:291375	10/78 (13%)
		RSN1_7TM	347..663	CDD:280815	72/346 (21%)
RSN1	NP_013993.1	COG5594	21..914	CDD:227881	169/848 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I1536
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54295
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46916
orthoMCL	1	0.900	-	-		OOG6_100323
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.770