Protein Alignment Tmem63 and PHM7

DIOPT Version :9

• Sequence 1: NP_610351.1
• Gene: Tmem63 / 35779
• FlyBaseID: FBgn0033259
• Length: 760
• Species: Drosophila melanogaster
• Sequence 2: NP_014557.1
• Gene: PHM7 / 854070
• SGDID: S000005444
• Length: 991
• Species: Saccharomyces cerevisiae
• Alignment Length: 698
• Identity: 134/698 - (19%)
• Similarity: 256/698 - (36%)
• Gaps: 158/698 - (22%)

  Fly    14 AVANRTSFFTTAYNGIPETLILNTIFWVLLILLFTVLRHQAGDFGRLALVNSNGSKKRWTEIFYS 78
            |.::.||.|.:       |||:..:..|:.:.||.:||
Yeast     2 ADSSSTSAFIS-------TLIIYGLTAVVFVWLFLLLR--------------------------- 32

  Fly    79 RAASVVDPQPSTSTQVSPRPSTTSQGVPDSTPLSPIQPEEGLFGWIRVTLKLRKETILLHTGPDA 143
                     |.......||.....|.:|:.....|:  .||.|||:...|......::.||..|.
Yeast    33 ---------PKNRRVYEPRSLKDIQTIPEEERTEPV--PEGYFGWVEYLLSKPHSFLIQHTSVDG 86

  Fly   144 VHYLSFQQHLMAVMALVTIVSLVIILPVNFLNGPKENPYDVNAFGRTTMAN-------LSPDSPW 201
            ...|.:...:.::..:..::.|.|:||||..||.....:::.:|...|..|       ||    |
Yeast    87 YFLLRYIGIVGSLSFVGCLLLLPILLPVNATNGNNLQGFELLSFSNVTNKNRFYAHVFLS----W 147

  Fly   202 LWVHTIITILYIPLVVLIMRRASGRNAFKKAATRTIMISNISSSDRNKTVV----------RNYM 256
            ::......::|..|...::        |:.|...|.:...:.||   :||:          ...|
Yeast   148 IFFGLFTYVIYKELYYYVV--------FRHAMQTTPLYDGLLSS---RTVIVTELHKSIAQEGEM 201

  Fly   257 QELFPDVTIENVSIAYNISRLY------VRNA------------------------EFERVH--- 288
            |..||..:  ||:.||::|.|.      .:||                        :.::::
Yeast   202 QMRFPKAS--NVAFAYDLSDLQELCKERAKNAAKYEAALNKVLNKCVKMTRNKTQKQLDKLYNNG 264

  Fly   289 -----EARLYCEHHRNRDTLMVKPEMC-SCKKENAYEYYQREERKLSGDVARLRAS-TMNEPLDI 346
                 :...|..|.:.....:.|..:| ..||.|...|..:...:|:.::...:|. ..|:....
Yeast   265 TKPKDDLETYVPHKKRPKHRLGKLPLCLGGKKVNTLSYSSKRIGELNEEIHEKQADWASNDRQPA 329

  Fly   347 AFITVSTVQEAQNIVTHFTPGTYRQWHLVFAP----------SPDDLFWENLNVNKSHWYLKFFC 401
            .||...|..|||.        .|:....:...          ||:|:.|.::.::....:.:...
Yeast   330 CFIQFETQLEAQR--------CYQSVEAILGKKNFGKRLIGYSPEDVNWGSMRLSSKERHSRRAV 386

  Fly   402 VNAVLFLVLFFLSTPAMVVSLLNS-------RPWVKETEGK---ISPLVADFLPTLMLWTLSALM 456
            .|.::.|::.|.:.|..||.::::       .|:::.....   :..::...|||:.|..|.:|:
Yeast   387 ANTIMVLLIIFWAFPVAVVGIISNVNFLTDKVPFLRFINNMPTFLMGVITGLLPTIALVVLMSLV 451

  Fly   457 PVIVAISDKWMRHYTRSKQNYSIMTKCFGYLLMMIMILPSLGLTSAQALLEWGFLNQTDRWQCIF 521
            |..:.:..|.....||  |...:.::.:.|...:|.|...:..||:.:......:::......:.
Yeast   452 PPFIVMLGKLSGCVTR--QETDLYSQAWYYAFAVIQIFLVVTATSSASSTVDSIIDRPRSAMTLL 514

  Fly   522 ---LPDRGSFYVNYIITAAFIGTALELLRFPELIVYIWSLLKAKSKAETP---YIRKAILIEFPF 580
               ||...:||:.|.|.....|....:|:...|::   |.:..:....||   :.|...|.....
Yeast   515 ANNLPKASNFYIMYFILKGLTGPTWTILQAVNLLL---SKVLGRVLDSTPRQKWNRYNTLATPRM 576

  Fly   581 GTHYAWTTLVFTIAIVYSVACPLIMPFAMIYICLKHFVDRHNLYFAYG 628
            |..|....::..|.|.||:..|:::.|:.:.:.|.:....:||.:.:|
Yeast   577 GIVYPGIEILVCIYICYSIIAPILLFFSTVMLTLLYVAYLYNLNYVFG 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmem63	NP_610351.1	RSN1_TM	32..220	CDD:290675	40/194 (21%)
		PHM7_cyt	270..328	CDD:291375	14/96 (15%)
		RSN1_7TM	347..663	CDD:280815	60/308 (19%)
PHM7	NP_014557.1	COG5594	4..985	CDD:227881	133/696 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I1536
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54295
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46916
orthoMCL	1	0.900	-	-		OOG6_100323
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1690
SonicParanoid	1	1.000	-	-		X290
TreeFam	0	0.000	Not matched by this tool.
	8	7.800