DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tmem63 and AT1G32090

DIOPT Version :9

Sequence 1:	NP_610351.1	Gene:	Tmem63 / 35779	FlyBaseID:	FBgn0033259	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_174489.1	Gene:	AT1G32090 / 840101	AraportID:	AT1G32090	Length:	806	Species:	Arabidopsis thaliana

Alignment Length:	730	Identity:	146/730 - (20%)
Similarity:	284/730 - (38%)	Gaps:	160/730 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 DFGRLALVNSNGSKKRWTEIFYSRAASVVDPQPSTSTQVSPRPSTTSQGVPDSTPLSPIQPEEGL 120
            |.|..||:|..|:      ..:..|.:|:..||.......|:...|.:      ..||.:.:..|
plant     6 DIGVSALINLFGA------FLFLIAFAVLRIQPINDRVYFPKWYLTGE------RNSPRRSDRTL 58

  Fly   121 FG---------------WIRVTLKLRKETILLHTGPDAVHYLSFQQHLMAVMALVTIVSLVIILP 170
            .|               |:...:|:.:..|:.|.|.|:..:|......:.:.|.|.:::||:::|
plant    59 VGKFVNLNYKTYFTFLNWMPQAMKMSESEIIRHAGLDSAIFLRIYTLGLKIFAPVMVLALVVLVP 123

  Fly   171 VNFLNG-----PKENPYDVNAFGRTTMANLSPDSPWLWVHTIITILYIPLVVLIMRRASGRNAFK 230
            ||..:|     .||  ..|:...:.:::|:.|.|...:.|..:..::......::.|.....|
plant   124 VNVSSGTLFFLKKE--LVVSNIDKLSISNVQPKSSKFFFHIAVEYIFTFWACFMLYREYNNVA-- 184

  Fly   231 KAATRTIMISNISSSDRNK-----TVVRNYMQELFPDVTIENV-------------------SIA 271
                  ||.....:|.|.:     .||||     .||:...:|                   ...
plant   185 ------IMRLQYLASQRRRPEQFTVVVRN-----VPDMPGHSVPDTVDQFFKTNHPEHYLCHQAV 238

  Fly   272 YN---ISRLYVRNAEFERVHEARLYCEHHRNRDTLMVKPEMCSC-------KKENAYEYYQREER 326
            ||   .::|..:.|:.:|..:..: .:|.||..    |...|..       |:.::.|||:::.:
plant   239 YNANTYAKLVKQRAKLQRWFDYYV-LKHQRNPH----KQPTCRTGFLGLWGKRVDSIEYYKQQIK 298

  Fly   327 KLSGDVARLRASTMNEP---LDIAFITVST---------VQEAQNIVTHFTPGTYRQWHLVFAPS 379
            :...:::..|...:.:.   |.:||::..:         .|:::|...         |....||.
plant   299 EFDHNMSLERQKVLKDSKLMLPVAFVSFDSRWGAAVCAQTQQSKNPTL---------WLTSSAPE 354

  Fly   380 PDDLFWENLNVNKSHWYLKFFCVNAVLFLVLFFLSTP-AMVVSLLNSRPWVKETEG--KISP--- 438
            |.|::|:||.:......::...:...:|.::||...| |.|.||.|       .||  :::|
plant   355 PRDIYWQNLAIPFISLTIRKLVIGVSVFALVFFYMIPIAFVQSLAN-------LEGLDRVAPFLR 412

  Fly   439 ----------LVADFLPTLMLWTLSALMPVIVAISDKWMRHYTRSKQNYSIMTKCFGYLLMMIMI 493
                      .:..|||.|.|.....::|.::.|..|...:...|........|.:.::|:.:.:
plant   413 PVTRLDFIKSFLQGFLPGLALKIFLWILPTVLLIMSKIEGYIALSTLERRAAAKYYYFMLVNVFL 477

  Fly   494 LPSLGLTSAQALLEWGFLNQT----DRWQCIFLPDRGSFYVNYIITAAFIGTALELLRFPELIVY 554
            ...:..|:.:.|  ..||:|:    .|...:.:|.:.:|::.||:...:.|.|.|:||...|:::
plant   478 GSIIAGTAFEQL--HSFLHQSPSQIPRTIGVSIPMKATFFITYIMVDGWAGIAGEILRLKPLVIF 540

  Fly   555 -IWSLLKAKSKAETPYIRKAILIEF----PFGTHYAWTTLVFTIAIVYSVACPLIMPFAMIYICL 614
             :.::...|::.:.........::|    |.      ..|.|.:.|||:...|:::||.:|:...
plant   541 HLKNMFIVKTEEDRVRAMDPGFVDFKETIPS------LQLYFLLGIVYTAVTPILLPFILIFFAF 599

  Fly   615 KHFVDRHNLYFAYGPSNMISRKGG----KIHSTAVTMTKFSVVILVLVMAMICFFRGDNGMARFL 675
            .:.|.||.:...|   |......|    .:|...:.....|.::|:.::|      .........
plant   600 AYLVYRHQIINVY---NQQYESCGAFWPHVHGRIIASLLISQLLLMGLLA------SKKAADSTP 655

  Fly   676 LLIISLAITLTLFTF 690
            ||||...:||:...:
plant   656 LLIILPILTLSFHKY 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmem63	NP_610351.1	RSN1_TM	32..220	CDD:290675	38/183 (21%)
		PHM7_cyt	270..328	CDD:291375	14/67 (21%)
		RSN1_7TM	347..663	CDD:280815	73/353 (21%)
AT1G32090	NP_174489.1	COG5594	3..716	CDD:227881	146/730 (20%)
AT1G32090	NP_174489.1	RSN1_7TM	373..644	CDD:397021	60/288 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	67	1.000	Domainoid score	I3494
eggNOG	1	0.900	-	-		E1_COG5594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54295
OrthoDB	1	1.010	-	-		D395194at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2398
orthoMCL	1	0.900	-	-		OOG6_100323
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X290
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.730