DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tmem63 and AT4G22120

DIOPT Version :9

Sequence 1:	NP_610351.1	Gene:	Tmem63 / 35779	FlyBaseID:	FBgn0033259	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_001078425.1	Gene:	AT4G22120 / 828301	AraportID:	AT4G22120	Length:	771	Species:	Arabidopsis thaliana

Alignment Length:	589	Identity:	125/589 - (21%)
Similarity:	243/589 - (41%)	Gaps:	134/589 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 WIRVTLKLRKETILLHTGPDAVHYLSFQQHLMAVMALVTIVSLVIILPVNFLNGPKE-------- 179
            |:...||:.:..::.|.|.|:|.||......:.:...:.:::..:::|||:.|...|
plant    75 WMPEALKMPEPELIDHAGLDSVVYLRIYWLGLKIFTPIAVLAWAVLVPVNWTNNTLEMAKQLRNV 139

  Fly   180 NPYDVNAFGRTTMANLSPDSPWLWVHTIITILYIPLVVLIMRR-----ASGRNAFKKAATR---- 235
            ...|::   :.:::|:...|...|.|.::...:......::.:     |:.|..|..:..|
plant   140 TSSDID---KLSVSNIPEYSMRFWTHIVMAYAFTIWTCYVLMKEYETIANMRLQFVASEARRPDQ 201

  Fly   236 -TIMISNISSSDRNKTV---VRNYMQELFPD--VTIENVSIAYNISRLYVRN------AEFERVH 288
             |:::.|: ..|.:::|   |.::.....||  :|.:.|..|..::.|..:.      .::.::.
plant   202 FTVLVRNV-PPDADESVSELVEHFFLVNHPDHYLTHQVVCNANKLADLVKKKKKLQNWLDYYQLK 265

  Fly   289 EARLYCEHHRNRDTLMVKPEMCSC--KKENAYEYYQREERKLSGDVARLRASTMNEP---LDIAF 348
            .||      .|...:|||......  :|.:|.|:|..|..|:|.::::.|...:|:|   :..||
plant   266 YAR------NNSQRIMVKLGFLGLWGQKVDAIEHYIAEIDKISKEISKEREEVVNDPKAIMPAAF 324

  Fly   349 ITVST---------VQEAQNIVTHFTPGTYRQWHLVFAPSPDDLFWEN-------LNVNKSHWYL 397
            ::..|         .|:.:|..         ||...:||.|.|:||.|       |.|.:...::
plant   325 VSFKTRWAAAVCAQTQQTRNPT---------QWLTEWAPEPRDVFWSNLAIPYVSLTVRRLIMHV 380

  Fly   398 KFFCVNAVLFLVLFFLSTPAMVVSL------LNSRPWVK--ETEGKISPLVADFLPTLMLWTLSA 454
            .||      ||..||:...|.|.||      :.:.|::|  ..:..:..::..|||.:.|....|
plant   381 AFF------FLTFFFIVPIAFVQSLATIEGIVKAAPFLKFIVDDKFMKSVIQGFLPGIALKLFLA 439

  Fly   455 LMPVIVAISDKWMRHYT-------RSKQNYSIMTKCFGYLLMMIMILPSLGLTSAQALLEW--GF 510
            .:|.|:.|..|: ..:|       |:...|        |:..::.:.  |....|.|..|.  .|
plant   440 FLPSILMIMSKF-EGFTSISSLERRAAFRY--------YIFNLVNVF--LASVIAGAAFEQLNSF 493

  Fly   511 LNQT----DRWQCIFLPDRGSFYVNYIITAAFIGTALELLRFPELIVYIWSLLKAKSKAETPYIR 571
            |||:    .:...:.:|.:.:|::.||:...:.|.|.|:|....||::              :::
plant   494 LNQSANQIPKTIGVAIPMKATFFITYIMVDGWAGVAGEILMLKPLIMF--------------HLK 544

  Fly   572 KAILIE-------------FPFGTHYAWTTLVFTIAIVYSVACPLIMPFAMIYICLKHFVDRHNL 623
            .|.|::             ..|.|......|.|.:.:||:...|:::||.:::..|.:.|.||.:
plant   545 NAFLVKTDKDREEAMDPGSIGFNTGEPRIQLYFLLGLVYAPVTPMLLPFILVFFALAYIVYRHQI 609

  Fly   624 YFAY 627
            ...|
plant   610 INVY 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmem63	NP_610351.1	RSN1_TM	32..220	CDD:290675	19/104 (18%)
		PHM7_cyt	270..328	CDD:291375	13/65 (20%)
		RSN1_7TM	347..663	CDD:280815	75/331 (23%)
AT4G22120	NP_001078425.1	COG5594	3..680	CDD:227881	125/589 (21%)
AT4G22120	NP_001078425.1	RSN1_7TM	374..645	CDD:367152	59/271 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	67	1.000	Domainoid score	I3494
eggNOG	1	0.900	-	-		E1_COG5594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54295
OrthoDB	1	1.010	-	-		D395194at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2398
orthoMCL	1	0.900	-	-		OOG6_100323
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X290
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.730