DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tmem63 and AT3G54510

DIOPT Version :9

Sequence 1:	NP_610351.1	Gene:	Tmem63 / 35779	FlyBaseID:	FBgn0033259	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_001118837.1	Gene:	AT3G54510 / 824616	AraportID:	AT3G54510	Length:	712	Species:	Arabidopsis thaliana

Alignment Length:	748	Identity:	152/748 - (20%)
Similarity:	277/748 - (37%)	Gaps:	207/748 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PETLI----LNTIFWVLLILLFTVLRHQAGDFGRLALVNSNGSKKRWTEIFYSRAASVVDPQPST 90
            ||:|:    :|....|:.:.||:||:.|                .|...::|:|
plant     3 PESLLASASINIGLAVVALWLFSVLKKQ----------------PRNAVVYYAR----------- 40

  Fly    91 STQVSPRPSTTSQGVPDSTPLSPIQPEEGLFGWIRVTLKLRKETILLHTGPDAVHYLSFQQHLMA 155
              ::|.|.......:..|..|....|.   ..||....::.::.||...|.||:..:...:..:.
plant    41 --RLSDRHHHRPLSLHSSLCLPRFLPS---VAWIPRAFRVPEDEILSRHGLDALVLIRLFKFGIR 100

  Fly   156 VMALVTIVSLVIILPVNFLNG---PKENPYDVNAFGRTTMANLSPDSPWLWVH--TIITILYIPL 215
            ...:.:::...::|||::.|.   |....|.::||   |::|::..|..||||  .:..|.:..|
plant   101 FFLMCSLLGASLLLPVDYYNESDLPTRREYSMDAF---TISNITRGSNKLWVHFSCLWCISFYAL 162

  Fly   216 V--------VLIMRRASGRNAFKKAATRTIMISNISSSDRNKTVVRNYMQELFPDVTIENVSIAY 272
            .        :|::|....:....:|...|:::..:               .|.|:......::.:
plant   163 FLLHKEYKEILVIRLQQMKELRHRADQFTVLVRQV---------------PLCPEHNTRGCAVDH 212

  Fly   273 NISRLYVRNAEFERVHEARLYCEH---HRNRDTLMVKPEMCSCKKE------------NAYEYYQ 322
            ..|:           |....|..|   :..||...:..:....|||            .:.|:.|
plant   213 FFSK-----------HHRFSYHSHQMLYDGRDLEYLLGKQKKLKKELEDKRHTEILSNGSQEHKQ 266

  Fly   323 ---REE--RKLSGDVARLRASTM--NEPLDIAFITVSTVQE---AQNIVTHFTPGTYRQWHLV-- 375
               .||  |:::..:..|::.||  .:.|.:||:|..:.:.   |.....|..|     ..|:
plant   267 ISTSEEKLREITHMIYHLQSETMLREKELPVAFVTFKSRRNAALAAQTQQHSNP-----LELITE 326

  Fly   376 FAPSPDDLFWENLNVNKSHWYL-KFFCVNAVLFLVLFFL------------------STPAMVVS 421
            .||.|.|:.|.||.:.:....| |...:.|...|.:||.                  ..|||.:.
plant   327 MAPEPRDVSWRNLAIPQKILPLNKIGVILAAALLTIFFAIPVTAVQGIAKYEKLKKWFPPAMAIE 391

  Fly   422 LLNSRPWVKETEGKISPLVADFLPTLMLWTLSALMPVIV--------AISDKWMRHYTRSKQNYS 478
            .:..          :|.:|..:||:.:|.....::|..:        :||:        ||:...
plant   392 FIPG----------LSSVVTGYLPSAILKGFMYIIPFAMLGLAYLGGSISN--------SKEEIK 438

  Fly   479 IMTKCFGYLLMMIMILPSLGLTSAQALLEWG--FLNQTDRWQCIFLPD--------RGSFYVNYI 533
            .....|.:|:..:..   |.|.|...|.|.|  ..:..|      :|.        :..|::.||
plant   439 ACNMVFYFLMGNVFF---LSLISGSLLDEIGEYLTHPRD------IPSHLAAAVSAQAEFFMTYI 494

  Fly   534 ITAAFIGTALELLRFPELIVY--IWSLLKAKSKAETPYIRKAILIEFPFGTHYAWTTLVFTIAIV 596
            :|....|.:||:|:. .||::  |.|....:.|..|||     |..||:.......:|...|.::
plant   495 LTDGLSGFSLEILQL-GLILFDIIRSYTYGRGKERTPY-----LFSFPYFRVIPTVSLSIMIGMI 553

  Fly   597 YSVACPLIMPFAMIYICLKHFVDRHNLYFAYGPSNMISRKGGKIHSTAVTMTKF--------SVV 653
            |:|..||::||.:.|.||.:.|..:.:...|             .:|..|..:|        .|.
plant   554 YAVVAPLMLPFLVGYFCLGYIVYFNQMEDVY-------------ETTYDTCGRFWPFIHHYIFVS 605

  Fly   654 ILVLVMAMICFF----RGDNGMARFLLLIISLA 682
            |:::.:.|:..|    :....:|...|::|::|
plant   606 IILMQITMVGLFGLKSKPSAAIATVPLILITIA 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmem63	NP_610351.1	RSN1_TM	32..220	CDD:290675	41/204 (20%)
		PHM7_cyt	270..328	CDD:291375	14/77 (18%)
		RSN1_7TM	347..663	CDD:280815	81/367 (22%)
AT3G54510	NP_001118837.1	COG5594	6..683	CDD:227881	150/745 (20%)
AT3G54510	NP_001118837.1	RSN1_7TM	350..616	CDD:397021	66/311 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	67	1.000	Domainoid score	I3494
eggNOG	1	0.900	-	-		E1_COG5594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54295
OrthoDB	1	1.010	-	-		D395194at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2398
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X290
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.830