DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tmem63 and TMEM63C

DIOPT Version :9

Sequence 1:	NP_610351.1	Gene:	Tmem63 / 35779	FlyBaseID:	FBgn0033259	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_065164.2	Gene:	TMEM63C / 57156	HGNCID:	23787	Length:	806	Species:	Homo sapiens

Alignment Length:	818	Identity:	238/818 - (29%)
Similarity:	396/818 - (48%)	Gaps:	108/818 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ENSNISYCQAVANRTSFFTTAYNGIPETLILNTIFWVLLILLFTVLRHQAGDFGRLALVNSNGSK 69
            :|..:..|....| |......:.|:|..|.||...|||::::::.||..|.|:|||||:..|.|
Human    15 QNMTVDECFQSRN-TVLQGQPFGGVPTVLCLNIALWVLVLVVYSFLRKAAWDYGRLALLIHNDS- 77

  Fly    70 KRWTEIFYSRAASVVDPQPSTSTQVSPRPSTTSQGVPDSTPLSPIQPEEGLFGWIRVTLKLRKET 134
              .|.:.|...:....|. .||.::..|                   ::|...|...::.::.|.
Human    78 --LTSLIYGEQSEKTSPS-ETSLEMERR-------------------DKGFCSWFFNSITMKDED 120

  Fly   135 ILLHTGPDAVHYLSFQQHLMAVMALVTIVSLVIILPVNFLNGPKENPYDVNA-FGRTTMANLSPD 198
            ::...|.||..|:.||.||:..:.::.|.||.||||:|:..    :..|.:: |.|||:.|:|.:
Human   121 LINKCGDDARIYIVFQYHLIIFVLIICIPSLGIILPINYTG----SVLDWSSHFARTTIVNVSTE 181

  Fly   199 SPWLWVHTIITILYIPLVVLIMRR----ASGRNAFKKAATRTIMISNISSSDRNKTVVRNYMQEL 259
            |..||:|::::..|.....:.|..    .:.||:.|  .|||:||:.:.....:..::..:..|.
Human   182 SKLLWLHSLLSFFYFITNFMFMAHHCLGFAPRNSQK--VTRTLMITYVPKDIEDPELIIKHFHEA 244

  Fly   260 FPDVTIENVSIAYNISRLYVRNAEFERVHEAR---LYCEHHRNRDTLMVK----PEMCSCK---- 313
            :|...:..|...|::..|.  :.:.:|.|..|   .|....:....:|::    ..:|.||
Human   245 YPGSVVTRVHFCYDVRNLI--DLDDQRRHAMRGRLFYTAKAKKTGKVMIRIHPCARLCFCKCWTC 307

  Fly   314 -KE-NAYEYYQREERKLSGDV-ARLRASTMNEPLDIAFITVST-----------------VQEAQ 358
             || :|.:||...|.:|:.:. |.|....:.. ||:.|:|...                 ||..|
Human   308 FKEVDAEQYYSELEEQLTDEFNAELNRVPLKR-LDLIFVTFQDSRMAKRVRKDYKYVQCGVQPQQ 371

  Fly   359 NIVTHFTPGTYRQWHLVFAPSPDDLFWENLNVNKSHWYLKFFCVNAVLFLVLFFLSTPAMVVSLL 423
            :.||......|  |.:..||.|.|:.|::|:|.:..|:.:|..:|..||.:.|||:|||::::.:
Human   372 SSVTTIVKSYY--WRVTMAPHPKDIIWKHLSVRRFFWWARFIAINTFLFFLFFFLTTPAIIMNTI 434

  Fly   424 NSRPWVKETEGKISPLVADFLPTLMLWTLSALMPVIVAISDKWMRHYTRSKQNYSIMTKCFGYLL 488
            :.....:..|...:|:|..|.|::|||..:.::|:||..|.....|:|||.||..::.||:.:|:
Human   435 DMYNVTRPIEKLQNPIVTQFFPSVMLWGFTVILPLIVYFSAFLEAHWTRSSQNLVMVHKCYIFLV 499

  Fly   489 MMIMILPSLGLTSAQALLEWGF----LNQTD-RWQCIFLPDRGSFYVNYIITAAFIGTALELLRF 548
            .|::||||:||||....|.|.|    |.|.. |:||:||||.|:|:|||:||||.:||.:||||.
Human   500 FMVVILPSMGLTSLDVFLRWLFDIYYLEQASIRFQCVFLPDNGAFFVNYVITAALLGTGMELLRL 564

  Fly   549 PELIVYIWSLLKAKSKAETPYIRKAILIEFPFGTHYAWTTLVFTIAIVYSVACPLIMPFAMIYIC 613
            ..|..|...|..::|:.|...|||...|:|.||..|||...||::.:.||:.||:|:||.::|:|
Human   565 GSLFCYSTRLFFSRSEPERVNIRKNQAIDFQFGREYAWMMNVFSVVMAYSITCPIIVPFGLLYLC 629

  Fly   614 LKHFVDRHNLYFAYGPSNMISRKGGKIHSTAVTMTKFSVVILVLVMAMICFFR-GD-NGMARFLL 676
            :||..||:|:|:::.|:.:    ..:||..||:...|:.::.:..|......| |. :.:..|.|
Human   630 MKHLTDRYNMYYSFAPTKL----NEQIHMAAVSQAIFAPLLGLFWMLFFSILRLGSLHAITIFSL 690

  Fly   677 LIISLAITLTLFTFMSPIKRCAATRRPSIVEI----------AGPAP---IYVPDVLKDNGIR-T 727
            ..:.:|:.:..........|..|...|...||          ....|   :||..||::..:. |
Human   691 STLLIAMVIAFVGIFLGKLRMVADYEPEEEEIQTVFDMEPSSTSSTPTSLLYVATVLQEPELNLT 755

  Fly   728 SSVRPSAAAFGGYGSDS------------VSEYDSSQY 753
            .:..|:...:|...:..            ..|.||:|:
Human   756 PASSPARHTYGTMNNQPEEGEEESGLRGFARELDSAQF 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmem63	NP_610351.1	RSN1_TM	32..220	CDD:290675	54/188 (29%)
		PHM7_cyt	270..328	CDD:291375	16/70 (23%)
		RSN1_7TM	347..663	CDD:280815	123/337 (36%)
TMEM63C	NP_065164.2	RSN1_TM	44..203	CDD:316484	53/185 (29%)
		PHM7_cyt	220..398	CDD:317147	42/182 (23%)
		RSN1_7TM	427..680	CDD:308377	99/256 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	755..781		3/25 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E1_COG5594
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	410	1.000	Inparanoid score	I1869
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54295
OrthoDB	1	1.010	-	-		D123365at33208
OrthoFinder	1	1.000	-	-		FOG0001439
OrthoInspector	1	1.000	-	-		otm41904
orthoMCL	1	0.900	-	-		OOG6_100323
Panther	1	1.100	-	-	O	PTHR13018
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1690
SonicParanoid	1	1.000	-	-		X290
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870