Protein Alignment Tmem63 and TMEM63B

DIOPT Version :10

• Sequence 1: NP_610351.1
• Gene: Tmem63 / 35779
• FlyBaseID: FBgn0033259
• Length: 760
• Species: Drosophila melanogaster
• Sequence 2: XP_016866488.1
• Gene: TMEM63B / 55362
• HGNCID: 17735
• Length: 841
• Species: Homo sapiens
• Alignment Length: 784
• Identity: 248/784 - (31%)
• Similarity: 408/784 - (52%)
• Gaps: 82/784 - (10%)

  Fly     6 NSN-ISYCQAVANRTSFFT-TAYNGIPETLILNTIFWVLLILLFTVLRHQAGDFGRLALVNSNGS 68
            ||| ..||.:...|::... ..:.|:|..|.|:.:.::.|:.||::||..|.|:|||||| ::..
Human    25 NSNPKDYCYSARIRSTVLQGLPFGGVPTVLALDFMCFLALLFLFSILRKVAWDYGRLALV-TDAD 88

  Fly    69 KKRWTEIFYSRAASVVDPQPSTSTQVSPRPSTTSQGVPDSTPLSPIQPEEGLFGWIRVTLKLRKE 133
            :.|..|........|.......|.....|.::.|..|...      |.:.|...|:....:::.:
Human    89 RLRRQERDRVEQEYVASAMHGDSHDRYERLTSVSSSVDFD------QRDNGFCSWLTAIFRIKDD 147

  Fly   134 TILLHTGPDAVHYLSFQQHLMAVMALVTIVSLVIILPVNFLNGPKENPYDVNAFGRTTMANLSPD 198
            .|....|.|||||||||:|::.::.:|.::|:.|:|||||.....||  :..:|||||:|||...
Human   148 EIRDKCGGDAVHYLSFQRHIIGLLVVVGVLSVGIVLPVNFSGDLLEN--NAYSFGRTTIANLKSG 210

  Fly   199 SPWLWVHTIITILYIPLVVLIMRRASGRNAFKK--AATRTIMISNISSSDRNKTVVRNYMQELFP 261
            :..||:||....||:.|.|..|||.:.:..:|:  ...||:.|:.||....::. ::.:.:|.:|
Human   211 NNLLWLHTSFAFLYLLLTVYSMRRHTSKMRYKEDDLVKRTLFINGISKYAESEK-IKKHFEEAYP 274

  Fly   262 DVTIENVSIAYNISRLYVRNAEFERVHEARLYCEHHRNRDTL--MVKPEMC---------SCKKE 315
            :.|:......||::||...:||.::....:||..:.::::.:  |:.|:.|         .|::.
Human   275 NCTVLEARPCYNVARLMFLDAERKKAERGKLYFTNLQSKENVPTMINPKPCGHLCCCVVRGCEQV 339

  Fly   316 NAYEYYQREERKLSGDVARLRASTMNEPLDIAFITVSTVQEAQNIVTHFT--------------P 366
            .|.|||.:.|:||..|..|.:.....:||.:||:|.........|:..|.              |
Human   340 EAIEYYTKLEQKLKEDYKREKEKVNEKPLGMAFVTFHNETITAIILKDFNVCKCQGCTCRGEPRP 404

  Fly   367 GTYRQ------WHLVFAPSPDDLFWENLNVNKSHWYLKFFCVNAVLFLVLFFLSTPAMVVSLLNS 425
            .:..:      |.:.:||.|.:::||:|::....|:|:...:|.|||::||||:|||::::.::.
Human   405 SSCSESLHISNWTVSYAPDPQNIYWEHLSIRGFIWWLRCLVINVVLFILLFFLTTPAIIITTMDK 469

  Fly   426 RPWVKETEGKISPLVADFLPTLMLWTLSALMPVIVAISDKWMRHYTRSKQNYSIMTKCFGYLLMM 490
            ....|..|...:|::..|.|||:||..|||:|.||..|..:..|:|||.:|.:.|.||:.:|:.|
Human   470 FNVTKPVEYLNNPIITQFFPTLLLWCFSALLPTIVYYSAFFEAHWTRSGENRTTMHKCYTFLIFM 534

  Fly   491 IMILPSLGLTSAQALLEWGF-----LNQTDRWQCIFLPDRGSFYVNYIITAAFIGTALELLRFPE 550
            :::||||||:|......|.|     .....|::|:||||.|:|:|||:|.:||||.|::|||.|.
Human   535 VLLLPSLGLSSLDLFFRWLFDKKFLAEAAIRFECVFLPDNGAFFVNYVIASAFIGNAMDLLRIPG 599

  Fly   551 LIVYIWSLLKAKSKAETPYIRKAILIEFPFGTHYAWTTLVFTIAIVYSVACPLIMPFAMIYICLK 615
            |::|:..|..|:|.||...:::....||.||..|||...|||:.:.||:.||:|:||.::|:.||
Human   600 LLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYAWMMCVFTVVMTYSITCPIIVPFGLMYMLLK 664

  Fly   616 HFVDRHNLYFAYGPSNMISRKGGKIHSTAVTMTKFSVVI----LVLVMAMICFFRGDNGMARFLL 676
            |.|||:|||:||.|:.:    ..||||.||.....:.::    |:....|...|.....|..|::
Human   665 HLVDRYNLYYAYLPAKL----DKKIHSGAVNQVVAAPILCLFWLLFFSTMRTGFLAPTSMFTFVV 725

  Fly   677 LIISLAITLTLFTF--------------------MSPIKRCAATRRPSIVEIAGPAPIYVPDVLK 721
            |:|::.|.|....|                    :.|    .:..||........:..|:..||:
Human   726 LVITIVICLCHVCFGHFKYLSAHNYKIEHTETDTVDP----RSNGRPPTAAAVPKSAKYIAQVLQ 786

  Fly   722 DNGI 725
            |:.:
Human   787 DSEV 790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmem63	NP_610351.1	COG5594	20..683	CDD:227881	232/705 (33%)
		RSN1_7TM	398..660	CDD:460661	111/270 (41%)
TMEM63B	XP_016866488.1	RSN1_TM	61..230	CDD:433613	60/177 (34%)
		PHM7_cyt	249..431	CDD:464272	42/182 (23%)
		RSN1_7TM	442..713	CDD:460661	112/274 (41%)