DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tmem63 and TMEM63B

DIOPT Version :9

Sequence 1:	NP_610351.1	Gene:	Tmem63 / 35779	FlyBaseID:	FBgn0033259	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	XP_005249268.1	Gene:	TMEM63B / 55362	HGNCID:	17735	Length:	841	Species:	Homo sapiens

Alignment Length:	784	Identity:	248/784 - (31%)
Similarity:	408/784 - (52%)	Gaps:	82/784 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NSN-ISYCQAVANRTSFFT-TAYNGIPETLILNTIFWVLLILLFTVLRHQAGDFGRLALVNSNGS 68
            ||| ..||.:...|::... ..:.|:|..|.|:.:.::.|:.||::||..|.|:|||||| ::..
Human    25 NSNPKDYCYSARIRSTVLQGLPFGGVPTVLALDFMCFLALLFLFSILRKVAWDYGRLALV-TDAD 88

  Fly    69 KKRWTEIFYSRAASVVDPQPSTSTQVSPRPSTTSQGVPDSTPLSPIQPEEGLFGWIRVTLKLRKE 133
            :.|..|........|.......|.....|.::.|..|...      |.:.|...|:....:::.:
Human    89 RLRRQERDRVEQEYVASAMHGDSHDRYERLTSVSSSVDFD------QRDNGFCSWLTAIFRIKDD 147

  Fly   134 TILLHTGPDAVHYLSFQQHLMAVMALVTIVSLVIILPVNFLNGPKENPYDVNAFGRTTMANLSPD 198
            .|....|.|||||||||:|::.::.:|.::|:.|:|||||.....||  :..:|||||:|||...
Human   148 EIRDKCGGDAVHYLSFQRHIIGLLVVVGVLSVGIVLPVNFSGDLLEN--NAYSFGRTTIANLKSG 210

  Fly   199 SPWLWVHTIITILYIPLVVLIMRRASGRNAFKK--AATRTIMISNISSSDRNKTVVRNYMQELFP 261
            :..||:||....||:.|.|..|||.:.:..:|:  ...||:.|:.||....::. ::.:.:|.:|
Human   211 NNLLWLHTSFAFLYLLLTVYSMRRHTSKMRYKEDDLVKRTLFINGISKYAESEK-IKKHFEEAYP 274

  Fly   262 DVTIENVSIAYNISRLYVRNAEFERVHEARLYCEHHRNRDTL--MVKPEMC---------SCKKE 315
            :.|:......||::||...:||.::....:||..:.::::.:  |:.|:.|         .|::.
Human   275 NCTVLEARPCYNVARLMFLDAERKKAERGKLYFTNLQSKENVPTMINPKPCGHLCCCVVRGCEQV 339

  Fly   316 NAYEYYQREERKLSGDVARLRASTMNEPLDIAFITVSTVQEAQNIVTHFT--------------P 366
            .|.|||.:.|:||..|..|.:.....:||.:||:|.........|:..|.              |
Human   340 EAIEYYTKLEQKLKEDYKREKEKVNEKPLGMAFVTFHNETITAIILKDFNVCKCQGCTCRGEPRP 404

  Fly   367 GTYRQ------WHLVFAPSPDDLFWENLNVNKSHWYLKFFCVNAVLFLVLFFLSTPAMVVSLLNS 425
            .:..:      |.:.:||.|.:::||:|::....|:|:...:|.|||::||||:|||::::.::.
Human   405 SSCSESLHISNWTVSYAPDPQNIYWEHLSIRGFIWWLRCLVINVVLFILLFFLTTPAIIITTMDK 469

  Fly   426 RPWVKETEGKISPLVADFLPTLMLWTLSALMPVIVAISDKWMRHYTRSKQNYSIMTKCFGYLLMM 490
            ....|..|...:|::..|.|||:||..|||:|.||..|..:..|:|||.:|.:.|.||:.:|:.|
Human   470 FNVTKPVEYLNNPIITQFFPTLLLWCFSALLPTIVYYSAFFEAHWTRSGENRTTMHKCYTFLIFM 534

  Fly   491 IMILPSLGLTSAQALLEWGF-----LNQTDRWQCIFLPDRGSFYVNYIITAAFIGTALELLRFPE 550
            :::||||||:|......|.|     .....|::|:||||.|:|:|||:|.:||||.|::|||.|.
Human   535 VLLLPSLGLSSLDLFFRWLFDKKFLAEAAIRFECVFLPDNGAFFVNYVIASAFIGNAMDLLRIPG 599

  Fly   551 LIVYIWSLLKAKSKAETPYIRKAILIEFPFGTHYAWTTLVFTIAIVYSVACPLIMPFAMIYICLK 615
            |::|:..|..|:|.||...:::....||.||..|||...|||:.:.||:.||:|:||.::|:.||
Human   600 LLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYAWMMCVFTVVMTYSITCPIIVPFGLMYMLLK 664

  Fly   616 HFVDRHNLYFAYGPSNMISRKGGKIHSTAVTMTKFSVVI----LVLVMAMICFFRGDNGMARFLL 676
            |.|||:|||:||.|:.:    ..||||.||.....:.::    |:....|...|.....|..|::
Human   665 HLVDRYNLYYAYLPAKL----DKKIHSGAVNQVVAAPILCLFWLLFFSTMRTGFLAPTSMFTFVV 725

  Fly   677 LIISLAITLTLFTF--------------------MSPIKRCAATRRPSIVEIAGPAPIYVPDVLK 721
            |:|::.|.|....|                    :.|    .:..||........:..|:..||:
Human   726 LVITIVICLCHVCFGHFKYLSAHNYKIEHTETDTVDP----RSNGRPPTAAAVPKSAKYIAQVLQ 786

  Fly   722 DNGI 725
            |:.:
Human   787 DSEV 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmem63	NP_610351.1	RSN1_TM	32..220	CDD:290675	63/187 (34%)
		PHM7_cyt	270..328	CDD:291375	17/68 (25%)
		RSN1_7TM	347..663	CDD:280815	127/344 (37%)
TMEM63B	XP_005249268.1	COG5594	49..839	CDD:227881	242/760 (32%)
		RSN1_TM	61..230	CDD:290675	60/177 (34%)
		YjgF_YER057c_UK114_family	<244..290	CDD:299145	10/46 (22%)
		PHM7_cyt	284..352	CDD:291375	17/67 (25%)
		RSN1_7TM	371..715	CDD:280815	127/347 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E1_COG5594
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	410	1.000	Inparanoid score	I1869
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54295
OrthoDB	1	1.010	-	-		D123365at33208
OrthoFinder	1	1.000	-	-		FOG0001439
OrthoInspector	1	1.000	-	-		otm41904
orthoMCL	1	0.900	-	-		OOG6_100323
Panther	1	1.100	-	-	O	PTHR13018
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1690
SonicParanoid	1	1.000	-	-		X290
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870