DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tmem63 and SPAC2G11.09

DIOPT Version :9

Sequence 1:	NP_610351.1	Gene:	Tmem63 / 35779	FlyBaseID:	FBgn0033259	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_593089.2	Gene:	SPAC2G11.09 / 2541980	PomBaseID:	SPAC2G11.09	Length:	793	Species:	Schizosaccharomyces pombe

Alignment Length:	844	Identity:	157/844 - (18%)
Similarity:	316/844 - (37%)	Gaps:	212/844 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LNTIFWVLLILLFTVLRHQAGDFGRLALVNSNGSKKRWTEIFYSRAASVVDPQPSTSTQVSPRPS 99
            |.|.||:..:|            |..|.|.....:||| ::.|:                   |.
pombe    21 LRTQFWLAFLL------------GASACVFFCFFRKRW-KVLYA-------------------PR 53

  Fly   100 TTSQGVPDSTPLSPIQPEEGLFGWIRVTLKLRKETILLHTGPDAVHYLSFQQHLMAVMALVTIVS 164
            ||.:|:...|..|      ..:.|:...:.:..:.:....|.|...:|.|.:..:..::..:::.
pombe    54 TTIEGLNLPTLSS------SYYKWLMDLVNIPDDVVQNCAGLDGYVFLLFFKMGIKFLSFASLLG 112

  Fly   165 LVIILPVN-----------FLNGPKENPY-----------------------DVNAFGRT---TM 192
            ::||:|||           .|:.|.::.|                       :|...|.:   .:
pombe   113 VLIIMPVNKHFRGDAFGNITLSMPAKSEYFFSSPLVKKSIVQSPIIANGSELNVGVLGPSLFNPI 177

  Fly   193 ANLS-------PDSPWLWVHTIITILYIPLVVLIMRRASGRNAF----------KKAATRTIMIS 240
            .|||       |...:|:::.:.| .:|.:.:|.:..:|.::..          .:...||:.||
pombe   178 GNLSDIPGLPQPGDGFLYLYVLFT-YFISIFLLYVLFSSTKSIADIRQSYLARQNRLTDRTVFIS 241

  Fly   241 NISSSDRNKTVVRNYMQELFPDV-TIENVSIAYNIS--------------------RLYVRN--- 281
            .:.:...:...::.|..:|  || :|:::||..|.|                    .:|:.|
pombe   242 GLPNELCSTENLKAYFDKL--DVGSIDSLSICRNYSYMDILLSKKSKYVKKLEKYWSIYLSNCKK 304

  Fly   282 ----------------AEFERVHEARLYC--EHHRNRDTLMVKPEMCSC--KKENAYEYYQREER 326
                            ||.|...|..|..  :||:...  ::|......  :|.:|.::|..:..
pombe   305 LGISTLPPSNYLSPNRAELESTPEQLLEVPWQHHQCHP--LIKTHFFGIFGQKIDAIDFYSAKLY 367

  Fly   327 KLSGDVARLRA---STMNEPLDIAFITVSTVQEAQNIV-THFTPGTYRQWHLVFAPSPDDLFWEN 387
            |:|..:...|:   .|..:    ||||..::..||.:. ||....:....|:..||:.:|:.|.|
pombe   368 KISQQIENARSFDYPTTGQ----AFITFESMATAQIVAQTHIDSKSLMGLHIELAPAANDIQWHN 428

  Fly   388 LNVNKSHWYLKFFCVNAVLFLVLFFLSTPAMVVSLLNSRPWVKETEGKISPLVAD---------- 442
            ..:.:.|.:.:.:.:..|.|:::...:.|...:::..:...::....::..::.|
pombe   429 TYIGRWHKFFQGWFITLVTFMIILLWTVPVGAIAVFINLDTIRRLWPELGRMIEDLPFLNSLLRT 493

  Fly   443 FLPTLMLWTLSALMPVIVAISDKWMRHY----TRSKQNYSIMTKCFGYLLM-MIMILPSLGLTSA 502
            |||||:.....::.|.:.    :|:...    :|:::....:.|.:.||.: ..::....|.||.
pombe   494 FLPTLVYSLFISISPFLF----RWLSSMQGLSSRAEEEIYAVGKNYAYLFVNFFLVYVIAGSTSI 554

  Fly   503 QALLEWGFLNQTDRWQCIF---LPDRGSFYVNYIITAAFIGTALELLRFPELIVYI-------WS 557
                 |.....|..:....   ||.:..|:::.|:........|:|::..:|..|.       :|
pombe   555 -----WELAKDTTSFAHFLANRLPHQAQFFIDLIVLQGIGMFPLKLIQLGKLSSYFVRRSFVPYS 614

  Fly   558 LLKAKSKAETPYIRKAILIEFPFGTHYAWTTLVFTIAIVYSVACPLIMPFAMIYICLKHFVDRHN 622
            :  |..|.|||       ..|..|........:..|.:.||:..|||:.|.:||..:...|.::.
pombe   615 I--ASKKFETP-------DSFSVGIFLPQPMFIMLICLCYSIISPLILVFGLIYFIIGFLVYKYE 670

  Fly   623 L-YFAYGPSNMISRKGGKIHSTAVTMTKFSVVILVLVMAMICFFRGDNGMARFLLLIISLAITLT 686
            | |....|.:    ..|::.||......|..||:.|.|..:...|....::..:..::...: ::
pombe   671 LIYQMEHPQH----STGELWSTIFLRMIFGCVIMQLTMMGLMSLRKAYWLSTVIFPLLCFTV-IS 730

  Fly   687 LFTFMSPIKRCAATRRPSIVEIAGPAPIYVPDVLKDNGIRTSSVRPSAAAFGGY---GSDSVSE 747
            .:.|.:.|       |.|:..::    :|.....:.|.:.:.|...::.:.|.|   |.|..:|
pombe   731 AYNFSTMI-------RSSMQFVS----LYYIRTHQSNTLSSESESRNSESSGSYVHPGFDLSNE 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmem63	NP_610351.1	RSN1_TM	32..220	CDD:290675	41/228 (18%)
		PHM7_cyt	270..328	CDD:291375	16/100 (16%)
		RSN1_7TM	347..663	CDD:280815	72/342 (21%)
SPAC2G11.09	NP_593089.2	COG5594	10..783	CDD:227881	156/842 (19%)
		RSN1_TM	20..213	CDD:290675	41/230 (18%)
		PHM7_cyt	270..369	CDD:291375	16/100 (16%)
		RSN1_7TM	387..708	CDD:280815	72/342 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54295
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47362
orthoMCL	1	0.900	-	-		OOG6_100323
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1690
SonicParanoid	1	1.000	-	-		X290
TreeFam	0	0.000	Not matched by this tool.
	7	6.750