DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tmem63 and SPBC354.08c

DIOPT Version :9

Sequence 1:	NP_610351.1	Gene:	Tmem63 / 35779	FlyBaseID:	FBgn0033259	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_595232.1	Gene:	SPBC354.08c / 2540988	PomBaseID:	SPBC354.08c	Length:	865	Species:	Schizosaccharomyces pombe

Alignment Length:	825	Identity:	160/825 - (19%)
Similarity:	302/825 - (36%)	Gaps:	211/825 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VANRTSFFTTAYN---------------GIPETLILNTIFWVLLILLFTVLRHQAGDFGRLALVN 64
            :..|.||.....|               .|..:|..:::..|:|:.:||:||.:...:.|.
pombe     3 IEKRESFIEVVINSLLNDNPAQAKFDKYSILVSLGFSSLLSVILLCIFTLLRTKFNTYDRC---- 63

  Fly    65 SNGSKKRWTEIFYSRAASVVDPQPSTSTQVSPRPSTTSQGVPDSTPLSPIQPEEGLFGWIRVTLK 129
                                                    :|   |:     ::.|:|||.....
pombe    64 ----------------------------------------IP---PM-----KKSLWGWIEPLWS 80

  Fly   130 LRKETILLHTGPDAVHYLSFQQHLMAVMALVTIVSLVIILPVNFL--NGPKENPYDVNAFGRTTM 192
            ::.|..|.:.|.|||..|.|.:....|..::..:...|::|:|.:  |....|....||:.:.::
pombe    81 IKVEDCLYNMGADAVISLLFSRFCRDVFLILAAICCTILIPINIVATNKTLANSDSQNAYAKLSI 145

  Fly   193 ANLSPDSPWLWVHTIITILYIPLVVLIMRR-----ASGRNAFKKAAT-------RTIMISNISSS 245
            .|::.:  |.|.|.:|..::..||:.::.|     ...|..:.::.|       |:::|.:|.::
pombe   146 QNVTGN--WTWAHVVICYVFNVLVLFLLARYYQIVMRIRQRYYRSPTYQQSMSSRSLLIMDIPTT 208

  Fly   246 DRNKTVVRNYMQELFPDVTIENVSIAY---NISRLYVRNAEFERVHEARLYCEHHRN-------R 300
            .|:...:......|.......:|.|.:   |:.::..::....|..||.| .:..:|       |
pombe   209 MRSNNGLSILASRLKSSEAPMHVHICHAIKNLPKILKKHDNAVRSLEAVL-AKFFKNPKKLPDDR 272

  Fly   301 DTLMVKPEMCSCKKENAYEYYQR--EERKLSGDVARLRASTMNEPLDIAFITVSTVQEAQNIVTH 363
            ....||..:.:.:|.:|.:||..  |...|..|.|| .:...||.....|||..:...|.:...|
pombe   273 PVRRVKQGLLTSEKVDAIDYYSAKIENYGLRVDAAR-ESLYENEFEHYGFITYKSSYIAHDTARH 336

  Fly   364 FT--PGTYRQWHLVFAPSPDDLFWENLNVNKSHWYLKFF--CVNAVLFLVL---FFLSTPAMVVS 421
            .:  .|.    .:..||.|.|..|:||::   .|..:.|  .:..:||::|   :.:.|..:.:.
pombe   337 NSRVAGA----SVSMAPEPSDFLWDNLSL---AWSTRLFNRMIGNILFIILIIAWIIETALVAIF 394

  Fly   422 LLNSR------PWVKE-----------TEGKISPLVADFLPTLMLWTLSALMPVIVAISDKWMRH 469
            :.|..      ||:::           .:|.:||.||.|  |.|      ::.:|:.....|...
pombe   395 ISNLYHLGSVWPWLQQQLTSRSGFWSIVQGILSPAVAGF--TFM------ILEIIMRRISYWQGS 451

  Fly   470 YTRSKQNYSIMTKCFGYLLMMIMILPSLGLTSAQALLEWGFLNQTDRWQCIFL-----PDRGSFY 529
            :|:|.:...::.|     |.:|..|.:..:.:..|:.          |:...:     .:.|:|.
pombe   452 FTKSSRERGVLNK-----LHIIFTLDNFIIYTLMAVF----------WRLGVIIAYKTKEEGNFA 501

  Fly   530 VNYIITAAFIGTALELLRFPELIVYIW-----------------------SLLKAKSKAETPYIR 571
            ......|.|....|.:..|.:...: |                       .|:|.|..:.||
pombe   502 EGMSAFATFDTVGLSVSSFVQFSTF-WIMFIAHSTCSFFVEIAQPITLTIRLIKTKFFSPTP--- 562

  Fly   572 KAILIEFPFGTHYAWTTLV------FTIAIVYSVACPLIMPFAMIYICLKHFVDRHNLYFAYGPS 630
             ..|:|:...|.|.::.::      |||||.|:...||::.||.:..|:.:...::.|.:.   |
pombe   563 -RDLLEWTAPTKYVYSQVLNKLIYFFTIAICYACINPLVLLFASVLFCVNYLTQKYILMYV---S 623

  Fly   631 NMISRKGGKIHSTAVTMTKFSVVILVLVMAMICFFRGDNGMARFLLLIISLAITLTLFTFMS--- 692
            |..:..||......|......:.:..:::.:..:.:|....|..::...|.||...::...:
pombe   624 NSSTESGGGYWRPVVNRILLGLELANIILFLCLWVQGGRVRAYCIIPNFSFAIAFKIWCMFALDP 688

  Fly   693 --------PIKRCAATRRPSIVE----IAGP---APIYVPDVLKD 722
                    |..:........|.|    ...|   ||:.||.|..|
pombe   689 KSHYMIEDPYMKVVEPLENEISESEMCFGHPSTYAPLLVPMVRSD 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmem63	NP_610351.1	RSN1_TM	32..220	CDD:290675	37/189 (20%)
		PHM7_cyt	270..328	CDD:291375	15/69 (22%)
		RSN1_7TM	347..663	CDD:280815	73/373 (20%)
SPBC354.08c	NP_595232.1	COG5594	1..863	CDD:227881	160/825 (19%)
		RSN1_TM	31..173	CDD:290675	38/195 (19%)
		PHM7_cyt	233..298	CDD:291375	14/65 (22%)
		RSN1_7TM	320..656	CDD:280815	73/373 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	51	1.000	Domainoid score	I3356
eggNOG	1	0.900	-	-		E1_COG5594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	96	1.000	Inparanoid score	I1698
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47362
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1690
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.890