DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tmem63 and Tmem63b

DIOPT Version :9

Sequence 1:	NP_610351.1	Gene:	Tmem63 / 35779	FlyBaseID:	FBgn0033259	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_937810.2	Gene:	Tmem63b / 224807	MGIID:	2387609	Length:	832	Species:	Mus musculus

Alignment Length:	785	Identity:	248/785 - (31%)
Similarity:	409/785 - (52%)	Gaps:	99/785 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YCQAVANRTSFFT-TAYNGIPETLILNTIFWVLLILLFTVLRHQAGDFGRLALVNSNGSKKRWTE 74
            ||.:...|::... ..:.|:|..|.|:.:.::.|:.||::||..|.|:|||||| ::..:.|..|
Mouse    22 YCYSARIRSTVLQGLPFGGVPTVLALDFMCFLALLFLFSILRKVAWDYGRLALV-TDADRLRRQE 85

  Fly    75 IFYSRAASVVDPQPSTSTQVSPRPSTTSQGVPDSTPLSPIQPEEGLFGWIRVTLKLRKETILLHT 139
            ........|.......|.....|.::.|..|...      |.:.|...|:....:::.:.|....
Mouse    86 RERVEQEYVASAMHGDSHDRYERLTSVSSSVDFD------QRDNGFCSWLTAIFRIKDDEIRDKC 144

  Fly   140 GPDAVHYLSFQQHLMAVMALVTIVSLVIILPVNFLNGPKENPYDVNAFGRTTMANLSPDSPWLWV 204
            |.|||||||||:|::.::.:|.::|:.|:|||||.....||  :..:|||||:|||...:..||:
Mouse   145 GGDAVHYLSFQRHIIGLLVVVGVLSVGIVLPVNFSGDLLEN--NAYSFGRTTIANLKSGNNLLWL 207

  Fly   205 HTIITILYIPLVVLIMRRASGRNAFKK--AATRTIMISNISSSDRNKTVVRNYMQELFPDVTIEN 267
            ||....||:.|.|..|||.:.:..:|:  ...||:.|:.||....::. ::.:.:|.:|:.|:..
Mouse   208 HTSFAFLYLLLTVYSMRRHTSKMRYKEDDLVKRTLFINGISKYAESEK-IKKHFEEAYPNCTVLE 271

  Fly   268 VSIAYNISRLYVRNAEFERVHEARLYCEHHRNRDTL--MVKPEMC---------SCKKENAYEYY 321
            ....||::||...:||.::....:||..:.::::.:  |:.|:.|         .|::..|.|||
Mouse   272 ARPCYNVARLMFLDAERKKAERGKLYFTNLQSKENVPAMINPKPCGHLCCCVVRGCEQVEAIEYY 336

  Fly   322 QREERKLSGDVARLRASTMNEPLDIAFIT-----------------------------VSTVQEA 357
            .:.|::|..|..|.:.....:||.:||:|                             .|:..||
Mouse   337 TKLEQRLKEDYRREKEKVNEKPLGMAFVTFHNETITAIILKDFNVCKCQGCTCRGEPRASSCSEA 401

  Fly   358 QNIVTHFTPGTYRQWHLVFAPSPDDLFWENLNVNKSHWYLKFFCVNAVLFLVLFFLSTPAMVVSL 422
            .:|         ..|.:.:||.|.:::||:|::....|:|:...:|.|||::||||:|||::::.
Mouse   402 LHI---------SNWTVTYAPDPQNIYWEHLSIRGFIWWLRCLVINVVLFILLFFLTTPAIIITT 457

  Fly   423 LNSRPWVKETEGKISPLVADFLPTLMLWTLSALMPVIVAISDKWMRHYTRSKQNYSIMTKCFGYL 487
            ::.....|..|...:|::..|.|||:||..|||:|.||..|..:..|:|||.:|.:.|.||:.:|
Mouse   458 MDKFNVTKPVEYLNNPIITQFFPTLLLWCFSALLPTIVYYSAFFEAHWTRSGENRTTMHKCYTFL 522

  Fly   488 LMMIMILPSLGLTSAQALLEWGF-----LNQTDRWQCIFLPDRGSFYVNYIITAAFIGTALELLR 547
            :.|:::||||||:|......|.|     .....|::|:||||.|:|:|||:|.:||||.|::|||
Mouse   523 IFMVLLLPSLGLSSLDLFFRWLFDKKFLAEAAIRFECVFLPDNGAFFVNYVIASAFIGNAMDLLR 587

  Fly   548 FPELIVYIWSLLKAKSKAETPYIRKAILIEFPFGTHYAWTTLVFTIAIVYSVACPLIMPFAMIYI 612
            .|.|::|:..|..|:|.||...:::....||.||..|||...|||:.:.||:.||:|:||.::|:
Mouse   588 IPGLLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYAWMMCVFTVVMTYSITCPIIVPFGLMYM 652

  Fly   613 CLKHFVDRHNLYFAYGPSNMISRKGGKIHSTAVTMTKFSVVI----LVLVMAMICFFRGDNGMAR 673
            .|||.|||:|||:||.|:.:    ..||||.||.....:.::    |:....|...|.....|..
Mouse   653 LLKHLVDRYNLYYAYLPAKL----DKKIHSGAVNQVVAAPILCLFWLLFFSTMRTGFLAPTSMFT 713

  Fly   674 FLLLIISLAITLT-----LFTFMS------------PIKRCAATRRPSIVEIAGPAP---IYVPD 718
            |::|:|::.|.|.     .|.::|            .:...:..|.|:    ||..|   .|:..
Mouse   714 FVVLVITIVICLCHVCFGHFKYLSAHNYKIEHTETDAVSSRSNGRPPT----AGAVPKSAKYIAQ 774

  Fly   719 VLKDN 723
            ||:|:
Mouse   775 VLQDS 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmem63	NP_610351.1	RSN1_TM	32..220	CDD:290675	63/187 (34%)
		PHM7_cyt	270..328	CDD:291375	17/68 (25%)
		RSN1_7TM	347..663	CDD:280815	128/353 (36%)
Tmem63b	NP_937810.2	RSN1_TM	52..221	CDD:372850	60/177 (34%)
		PHM7_cyt	240..422	CDD:373236	42/191 (22%)
		RSN1_7TM	433..704	CDD:367152	112/274 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..767		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	776..818		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2439
eggNOG	1	0.900	-	-		E1_COG5594
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	408	1.000	Inparanoid score	I1857
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54295
OrthoDB	1	1.010	-	-		D123365at33208
OrthoFinder	1	1.000	-	-		FOG0001439
OrthoInspector	1	1.000	-	-		otm43952
orthoMCL	1	0.900	-	-		OOG6_100323
Panther	1	1.100	-	-	O	PTHR13018
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X290
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840