DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tmem63 and Tmem63c

DIOPT Version :9

Sequence 1:	NP_610351.1	Gene:	Tmem63 / 35779	FlyBaseID:	FBgn0033259	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_001348633.1	Gene:	Tmem63c / 217733	MGIID:	2444386	Length:	802	Species:	Mus musculus

Alignment Length:	811	Identity:	241/811 - (29%)
Similarity:	395/811 - (48%)	Gaps:	135/811 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 YNGIPETLILNTIFWVLLILLFTVLRHQAGDFGRLALVNSNGSKKRWTEIFYSRAASVVDPQPST 90
            :.|||..|:||.|.||.::||::.||..|.|:|||||:..|.|   .|.:.|...:     :.|:
Mouse    33 FGGIPTVLVLNIILWVFVVLLYSFLRKAAWDYGRLALLIHNDS---LTSLIYGEQS-----EKSS 89

  Fly    91 STQVSPRPSTTSQGVPDSTPLSPIQPEEGLFGWIRVTLKLRKETILLHTGPDAVHYLSFQQHLMA 155
            .::||               |...:.:.|...|...:|.:|...::...|.||..|::||.||:.
Mouse    90 PSEVS---------------LEAERRDRGFSSWFFNSLTMRDRDLINKCGDDARIYITFQYHLII 139

  Fly   156 VMALVTIVSLVIILPVNFLNGPKENPYDVNA-FGRTTMANLSPDSPWLWVHTIITILYIPLVVLI 219
            .:.::.|.||.||||||::.    ...|.|: |||||:.|:|.:|.:||:|::...||..:.:..
Mouse   140 FVLILCIPSLGIILPVNYIG----TVLDWNSHFGRTTIVNVSTESKFLWLHSLFAFLYFLINLAF 200

  Fly   220 MRRASGRNAF----KKAA--TRTIMISNISSSDRNKTVVRNYMQELFPDVTIENVSIAYNISRLY 278
            |    |.:..    ||:.  |||:||:.:.:..::..::..:..|.:|...:..|...|::..|.
Mouse   201 M----GHHCLGFVPKKSLHFTRTLMITYVPTEIQDPEIISKHFHEAYPGCVVTRVHFCYDVRNLI 261

  Fly   279 VRNAEFERVHEAR---LYCEHHRNRDTLMVKPEMCS---------CKKE-NAYEYYQREERKLSG 330
              :.:.:|.|..|   .|....:....:|:|...||         |.|| :|.:||...|.:|:.
Mouse   262 --DLDDQRRHAMRGRLYYTAKAKKTGKVMIKTHPCSRLCFCKCWTCFKEVDAEQYYSELEEQLTD 324

  Fly   331 DV-ARLRASTMNEPLDIAFITVSTVQEAQNI-----------------VTHFTPGTYRQWHLVFA 377
            :. |.|....:.. ||:.|:|....:..:.|                 ||......:  |.:..|
Mouse   325 EFNAELNRVQLKR-LDLIFVTFQDARTVRRIYDDYKYIHCGRHPKQSSVTTIVKNYH--WRVAHA 386

  Fly   378 PSPDDLFWENLNVNKSHWYLKFFCVNAVLFLVLFFLSTPAMVVSLLNSRPWVKETEGKISPLVAD 442
            |.|.|:.|::|::.:..|:.:|..:|..||.:.|||:|||::::.::.....:..|...||:|..
Mouse   387 PHPKDIIWKHLSIRRFSWWTRFIAINTFLFFLFFFLTTPAIIINTIDIYNVTRPIEKLQSPIVTQ 451

  Fly   443 FLPTLMLWTLSALMPVIVAISDKWMRHYTRSKQNYSIMTKCFGYLLMMIMILPSLGLTSAQALLE 507
            |.|:::||..:..||::|.:|.....|:|||.||..|:.||:.:|:.|::||||:||||....|.
Mouse   452 FFPSVLLWAFTVTMPLLVYLSAFLEAHWTRSSQNLIIVHKCYIFLVFMVVILPSMGLTSLHVFLR 516

  Fly   508 WGF-----LNQTDRWQCIFLPDRGSFYVNYIITAAFIGTALELLRFPELIVYIWSLLKAKSKAET 567
            |.|     .:.|.|:||:||||.|:|::||:||||.:||.:||:|...|..|...|..:||:.|.
Mouse   517 WLFDIYYLEHATIRFQCVFLPDNGAFFINYVITAALLGTGMELMRLGSLCTYCTRLFLSKSEPER 581

  Fly   568 PYIRKAILIEFPFGTHYAWTTLVFTIAIVYSVACPLIMPFAMIYICLKHFVDRHNLYFAYGPSNM 632
            .:|||....:|.||..|||...||::.:.||:.||:|:||.::|:|:||..||:|:|::|.|:.:
Mouse   582 VHIRKNQATDFQFGREYAWMLNVFSVVMAYSITCPIIVPFGLLYLCMKHITDRYNMYYSYAPTKL 646

  Fly   633 ISRKGGKIHSTAVTMTKFSVVILVLVMAMICFFRGDNGMARFLLLIISLAITLTLFTFMSPI--- 694
                ..:||..||....|:.::            |...|..|.:|.:....::|||:..|.|
Mouse   647 ----NAQIHMAAVYQAIFAPLL------------GLFWMLFFSILRVGSLHSITLFSMSSLIISV 695

  Fly   695 ----------KRCAATR--------------RPSIVEIAGPAPIYVPDVLKDNGIR-TSSVRPSA 734
                      |...|.|              .||.......:.:||..||::..:. |.:..|:.
Mouse   696 VIAFSGVFLGKLRIAQRYEQPEEETETVFDVEPSSTTSTPTSLLYVATVLQEPELNLTPASSPAR 760

  Fly   735 AAFGGYGSDS------------VSEYDSSQY 753
            ..:|...|..            ..|.||:|:
Mouse   761 HTYGTINSQPEEGEEESGLRGFARELDSAQF 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmem63	NP_610351.1	RSN1_TM	32..220	CDD:290675	61/188 (32%)
		PHM7_cyt	270..328	CDD:291375	17/70 (24%)
		RSN1_7TM	347..663	CDD:280815	117/337 (35%)
Tmem63c	NP_001348633.1	RSN1_TM	38..196	CDD:372850	61/184 (33%)
		PHM7_cyt	218..396	CDD:373236	40/182 (22%)
		RSN1_7TM	425..678	CDD:367152	100/268 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	753..785		4/31 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2439
eggNOG	1	0.900	-	-		E1_COG5594
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	408	1.000	Inparanoid score	I1857
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54295
OrthoDB	1	1.010	-	-		D123365at33208
OrthoFinder	1	1.000	-	-		FOG0001439
OrthoInspector	1	1.000	-	-		otm43952
orthoMCL	1	0.900	-	-		OOG6_100323
Panther	1	1.100	-	-	O	PTHR13018
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1690
SonicParanoid	1	1.000	-	-		X290
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870