Protein Alignment Tmem63 and tmem63c

DIOPT Version :9

• Sequence 1: NP_610351.1
• Gene: Tmem63 / 35779
• FlyBaseID: FBgn0033259
• Length: 760
• Species: Drosophila melanogaster
• Sequence 2: XP_012823241.1
• Gene: tmem63c / 100036641
• XenbaseID: XB-GENE-992232
• Length: 812
• Species: Xenopus tropicalis
• Alignment Length: 807
• Identity: 239/807 - (29%)
• Similarity: 408/807 - (50%)
• Gaps: 116/807 - (14%)

  Fly    26 YNGIPETLILNTIFWVLLILLFTVLRHQAGDFGRLALVNSNGS---KKRW-----TEIFYSRAAS 82
            :.|||..|.:|.:.|::|:|:|:.||..|.|:|||||:..|.|   ::||     |.:||...:.
 Frog    42 FGGIPTVLAINFLAWLVLLLIFSCLRKAAWDYGRLALLIDNDSHALQRRWTSYDLTSLFYGEPSE 106

  Fly    83 VVDPQPSTSTQVSPRPSTTSQGVPDSTPLSPIQPEEGLFGWIRVTLKLRKETILLHTGPDAVHYL 147
                :..:..::||..::|.              :.||..|:....:::.|.|....|.||:.||
 Frog   107 ----KEKSPCEISPSEASTK--------------DVGLCSWLSSIYQMKDEEIQSKCGSDAITYL 153

  Fly   148 SFQQHLMAVMALVTIVSLVIILPVNFL-----NGPKENPYDVNAFGRTTMANLSPDSPWLWVHTI 207
            |:|:||:.|:..|..:|:.|||||||.     :.|.:       |||||:.|:.....:||:|::
 Frog   154 SYQRHLLVVLLAVCCISVAIILPVNFSGDMLGDSPAQ-------FGRTTIVNVPTKDRFLWLHSV 211

  Fly   208 ITILYIPLVVLIMRRASGRNAFKK--AATRTIMISNISSSDRNKTVVRNYMQELFPDVTIENVSI 270
            ..::|....||.||..:....:|:  ...||:||:.|.|...:.::...:..|.:|..|:.:|..
 Frog   212 FALVYFLFSVLCMRHHTSSLHYKEDDKVARTLMITKIPSEISDASLFTKHFHEAYPSCTVTDVQF 276

  Fly   271 AYNISRLYVRNAEFERVHEARLYCEHHRNRD---TLMVKP--EMCSC-----KKENAYEYYQREE 325
            .|::..|...:.|..|..:.|:|......::   .:.:.|  .:|.|     ::..|.:||...|
 Frog   277 CYDVRHLMKLDKERRRAMKGRMYFAGRAQKEGKIQIKIHPCARLCPCDCCGFQQVEAEQYYGELE 341

  Fly   326 RKLSGDVARLRASTMNEPLDIAFITVS-------TVQEAQNIVTHFTPG--------TYRQWHLV 375
            .:|:.:....|.....:.|...|:|..       .:::...:..|..|.        ...:|.:.
 Frog   342 ERLTDEFTAERNRITLKRLGAVFVTFQDERMTAVIIKDYNRLPCHRAPQQSSVTPLLKSHKWKVH 406

  Fly   376 FAPSPDDLFWENLNVNKSHWYLKFFCVNAVLFLVLFFLSTPAMVVSLLNSRPWVKETEGKISPLV 440
            :||:|.|:.||||.|:.:.|:.:|..:|.:||::||||:|||::||.::........|...:|::
 Frog   407 YAPAPSDIIWENLAVSGALWWFRFLALNLLLFVLLFFLTTPAVIVSTMDRFNVTYPVEKLRNPVI 471

  Fly   441 ADFLPTLMLWTLSALMPVIVAISDKWMRHYTRSKQNYSIMTKCFGYLLMMIMILPSLGLTSAQAL 505
            ..||||.:||..|..:|.:|..|..:..|:|||.:|...|.||:.:|:.|:::||||||||....
 Frog   472 TQFLPTFLLWMFSVCLPFLVYYSAFFECHWTRSSENQHTMHKCYFFLVFMVIVLPSLGLTSLNLF 536

  Fly   506 LEW----GFLNQTD-RWQCIFLPDRGSFYVNYIITAAFIGTALELLRFPELIVYIWSLLKAKSKA 565
            ..|    .||::.: ::||:|||:.|:|:|||:|||:.||||:||||||.|.||...|..|:::.
 Frog   537 FRWLFDIHFLDEANIKFQCVFLPNNGAFFVNYVITASLIGTAMELLRFPGLTVYAARLCLARTEP 601

  Fly   566 ETPYIRKAILIEFPFGTHYAWTTLVFTIAIVYSVACPLIMPFAMIYICLKHFVDRHNLYFAYGPS 630
            :..::::....||.||..|||||.||::.:.||:.||:|:||.:||:.|||..||:|:|:||.|:
 Frog   602 DRLHVKRNQAYEFQFGLEYAWTTCVFSVVMAYSITCPVIVPFGLIYMLLKHMTDRYNIYYAYIPT 666

  Fly   631 NMISRKGGKIHSTAVTMTKFSVVILVLVMAMICFFRGDNGMARFLLLIISLAITLTLFTF----- 690
            .:    ...:|..|...        :|...::|.|    .:..|.:|.:.....:|||||
 Frog   667 KL----SPGLHKAAAYQ--------MLAAPVLCIF----WLLFFSVLRLGSTHPVTLFTFAVLLF 715

  Fly   691 ---MSPIKRC---AATRRPSIVEIAGP------------------APIYVPDVLKDNGIRTSSVR 731
               .|....|   ....|||..:::.|                  :.::|..||::..: :....
 Frog   716 CLLFSTFGLCLKKLQPNRPSSYQMSEPNEGIIQDTERSSISSTIQSNVFVASVLQEQEL-SPLAS 779

  Fly   732 PSAAAFGGYGSDSVSEYDSSQYSVNSV 758
            |:.|::|...:.:.:..|..:.:..|:
 Frog   780 PAHASYGALETRTDTPGDEQETTPESM 806

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmem63	NP_610351.1	RSN1_TM	32..220	CDD:290675	62/200 (31%)
		PHM7_cyt	270..328	CDD:291375	13/67 (19%)
		RSN1_7TM	347..663	CDD:280815	122/335 (36%)
tmem63c	XP_012823241.1	RSN1_TM	47..219	CDD:372850	60/196 (31%)
		PHM7_cyt	240..418	CDD:373236	36/177 (20%)
		RSN1_7TM	445..700	CDD:367152	103/270 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	233	1.000	Domainoid score	I2341
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	417	1.000	Inparanoid score	I1771
OMA	1	1.010	-	-		QHG54295
OrthoDB	1	1.010	-	-		D123365at33208
OrthoFinder	1	1.000	-	-		FOG0001439
OrthoInspector	1	1.000	-	-		otm49126
Panther	1	1.100	-	-	O	PTHR13018
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1690
SonicParanoid	1	1.000	-	-		X290
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110