DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sand and KCNK6

DIOPT Version :9

Sequence 1:	NP_610349.1	Gene:	sand / 35777	FlyBaseID:	FBgn0033257	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_004814.1	Gene:	KCNK6 / 9424	HGNCID:	6281	Length:	313	Species:	Homo sapiens

Alignment Length:	360	Identity:	82/360 - (22%)
Similarity:	130/360 - (36%)	Gaps:	115/360 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GIILLVTFYIIGGAFIFQSIEIFEYERLKSEKPHRFIARNFSGECLSRIWELTAENI-SFFDHHA 98
            |.:.....|::.||.:...:|.....||::|      ......:.|.|...:.|..: :|.:...
Human     9 GALAAYAAYLVLGALLVARLEGPHEARLRAE------LETLRAQLLQRSPCVAAPALDAFVERVL 67

  Fly    99 YRRRVNDVLLDYQRAIVKKQLKGPDVEQWSFSGAFLYSLTVITTIGYGNITPHSECGKLVTILYA 163
            ...|:..|:|    |.........| ..|.|:.|..::.|:|||:|||..||.::.||..:|.:|
Human    68 AAGRLGRVVL----ANASGSANASD-PAWDFASALFFASTLITTVGYGYTTPLTDAGKAFSIAFA 127

  Fly   164 IIGMPLFLLYLSNIGDVLA----------KSFKWIYSKVCLCRICPGVAKRRIIRERRKMRQLAR 218
            ::|:|..:|.|:.....|:          .|.:|.:..                         .|
Human   128 LLGVPTTMLLLTASAQRLSLLLTHVPLSWLSMRWGWDP-------------------------RR 167

  Fly   219 ALQMHDMENARGSSSYTSTSSTTSSNSSSSEYTRSSRQSSSLVDIQYTESDSDIEREIRGSTDEI 283
            |...|                                    ||.:                   :
Human   168 AACWH------------------------------------LVAL-------------------L 177

  Fly   284 TVPVTVCVFVMVGYILWGALLFGRWED-WNYLDGSYFCLISLSSIGFGDLVPGDRVITADRDKVE 347
            .|.||||..|       .|::|...|: |::||..|||.||||:||.||.|||:......|...:
Human   178 GVVVTVCFLV-------PAVIFAHLEEAWSFLDAFYFCFISLSTIGLGDYVPGEAPGQPYRALYK 235

  Fly   348 VSFILCAIYLLLGMAVIAMCFNLMQEQVVHNIRAI 382
            |   |..:||.||:  :||...|...:.|.::..:
Human   236 V---LVTVYLFLGL--VAMVLVLQTFRHVSDLHGL 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sand	NP_610349.1	Ion_trans_2	123..183	CDD:285168	22/69 (32%)
sand	NP_610349.1	Ion_trans_2	292..377	CDD:285168	31/85 (36%)
KCNK6	NP_004814.1	Ion_trans_2	<91..146	CDD:285168	20/54 (37%)
		Ion_trans_2	180..256	CDD:285168	35/87 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	288..313
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10857
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810