DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sand and Kcnk10

DIOPT Version :9

Sequence 1:	NP_610349.1	Gene:	sand / 35777	FlyBaseID:	FBgn0033257	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_075584.1	Gene:	Kcnk10 / 65272	RGDID:	619732	Length:	538	Species:	Rattus norvegicus

Alignment Length:	376	Identity:	89/376 - (23%)
Similarity:	143/376 - (38%)	Gaps:	124/376 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VGIILLVTFYIIGGAFIFQSIEIFEYERLKSEKPHRFIARNFSGECLSRIWELTAENISFF-DHH 97
            |.|.::|..|::.|..:|:::          |:|.....:|          .:..|...|. ||.
  Rat    73 VAIFVVVVVYLVTGGLVFRAL----------EQPFESSQKN----------TIALEKAEFLRDHI 117

  Fly    98 AYRRRVNDVL----LDYQRAIVKKQLKGPD-VEQWSFSGAFLYSLTVITTIGYGNITPHSECGKL 157
            ....:..:.|    ||...|.|.......: ...|....||.::.|||||||||||.|.:|.||:
  Rat   118 CVSPQELETLIQHALDADNAGVSPVGNSSNSSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKI 182

  Fly   158 VTILYAIIGMPLFLLYLSNIGDVLAKSFKWIYSKVCLCRICPGVAKRRIIRERRKMRQLARALQM 222
            ..|||||.|:|||...|:.|||.|...|              |.:..|:.:..||
  Rat   183 FCILYAIFGIPLFGFLLAGIGDQLGTIF--------------GKSIARVEKVFRK---------- 223

  Fly   223 HDMENARGSSSYTSTSSTTSSNSSSSEYTRSSRQSSSLVDIQYTESDSDIEREIRGSTDEITVPV 287
                                            :|.|              :.:||        .:
  Rat   224 --------------------------------KQVS--------------QTKIR--------VI 234

  Fly   288 TVCVFVMVGYILW---GALLFGRWEDWNYLDGSYFCLISLSSIGFGDLVPGDRVITADRD--KVE 347
            :..:|::.|.|::   .|::|...|.|..|:..||.:::|:::||||.|.|.......|:  |..
  Rat   235 STILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPL 299

  Fly   348 VSFILCAIYLLLGMAVIAMCFNLM----------QEQVVHNIRAIKRGFKA 388
            |.|     ::|:|:|..|...:::          .::.|..|:|....:||
  Rat   300 VWF-----WILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAHAAEWKA 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sand	NP_610349.1	Ion_trans_2	123..183	CDD:285168	32/60 (53%)
sand	NP_610349.1	Ion_trans_2	292..377	CDD:285168	25/99 (25%)
Kcnk10	NP_075584.1	Ion_trans_2	148..206	CDD:400301	31/57 (54%)
		Ion_trans_2	244..323	CDD:400301	23/83 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..444
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9664
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910