DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sand and kcnk1b

DIOPT Version :9

Sequence 1:	NP_610349.1	Gene:	sand / 35777	FlyBaseID:	FBgn0033257	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_001277277.1	Gene:	kcnk1b / 561206	ZFINID:	ZDB-GENE-090312-78	Length:	337	Species:	Danio rerio

Alignment Length:	376	Identity:	84/376 - (22%)
Similarity:	141/376 - (37%)	Gaps:	136/376 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 FMFSNVGIILLVTFYIIGGAFIFQSIE------------------IFEYERLKSEKPHRFIARNF 75
            |:|..:|.:|    |:|.||.:|.|:|                  :.|::.|..|:..||
Zfish    23 FLFLVLGYVL----YLIFGAVVFSSVELPYEDDLRQQLREIKRLFLQEHQCLSEERLERF----- 78

  Fly    76 SGECLSRIWELTAENISFFDHHAYRRRVNDVLLDYQRAIVKKQLKGPDVEQWSFSGAFLYSLTVI 140
                ||:..|.:...:|.         :|:....:               .|.|:.:..::.||:
Zfish    79 ----LSKALEASNYGVSI---------LNNASASW---------------NWDFTSSLFFASTVL 115

  Fly   141 TTIGYGNITPHSECGKLVTILYAIIGMPLFLLYLSNIGDVLAKSFKWIYSKVCLCRICPGVAKRR 205
            :|.|||:..|.|:.||...|:|::||:|..||:|:.:...:.....|                |.
Zfish   116 STTGYGHTAPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRIMVYSTW----------------RP 164

  Fly   206 IIRERRKMRQLARALQMHDMENARGSSSYTSTSSTTSSNSSSSEYTRSSRQSSSLVDIQYTESDS 270
            |:                          |.              :||.. .|..||.:.:.
Zfish   165 IM--------------------------YV--------------HTRWG-LSKPLVALVHA---- 184

  Fly   271 DIEREIRGSTDEITVPVTVCVFVMVGYILWGALLFGRWEDWNYLDGSYFCLISLSSIGFGDLVPG 335
                       .:...|.|..|.::...::.||    .|:||:|:..|||.||||:||.||.|||
Zfish   185 -----------TLLAVVAVSCFFLIPAAIFSAL----EENWNFLESFYFCFISLSTIGLGDYVPG 234

  Fly   336 DRVITADRDKVEVSFILCAIYLLLGMAVIAMCFNLMQEQVVHNIRAIKRGF 386
            :......|:..::..   .:|||||:  |||...|.....:..::.:::.|
Zfish   235 EAFNQRFRELYKLGI---TVYLLLGL--IAMLVVLETFCELQQLKQLRKMF 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sand	NP_610349.1	Ion_trans_2	123..183	CDD:285168	20/59 (34%)
sand	NP_610349.1	Ion_trans_2	292..377	CDD:285168	31/84 (37%)
kcnk1b	NP_001277277.1	Ion_trans_2	<99..157	CDD:285168	20/72 (28%)
kcnk1b	NP_001277277.1	Ion_trans_2	192..267	CDD:285168	32/83 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10296
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.810