DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sand and KCNK3

DIOPT Version :9

Sequence 1:	NP_610349.1	Gene:	sand / 35777	FlyBaseID:	FBgn0033257	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_002237.1	Gene:	KCNK3 / 3777	HGNCID:	6278	Length:	394	Species:	Homo sapiens

Alignment Length:	349	Identity:	83/349 - (23%)
Similarity:	140/349 - (40%)	Gaps:	121/349 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NVGIILLV--TF-YIIGGAFIFQSI----EIFEYERLKSEKPHRFIARNFSGECLSRIWELTAE- 89
            ||..:.|:  || |::.||.:|.::    |:.|.:||:                 .|..||.|.
Human     5 NVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLE-----------------LRQQELRARY 52

  Fly    90 NISFFDHHAYRRRVNDVLLDYQRAIVKKQLKGPDVEQWSFSGAFLYSLTVITTIGYGNITPHSEC 154
            |:|   ...|.        :.:|.:::.:.....| ||.|:|:|.:::|||||||||:..|.::.
Human    53 NLS---QGGYE--------ELERVVLRLKPHKAGV-QWRFAGSFYFAITVITTIGYGHAAPSTDG 105

  Fly   155 GKLVTILYAIIGMPLFLLYLSNIGDVLAKSFKWIYSKVCLCRICPGVAKRRIIRERRKMRQLARA 219
            ||:..:.||::|:||.|:...::|:                                ::..|.|.
Human   106 GKVFCMFYALLGIPLTLVMFQSLGE--------------------------------RINTLVRY 138

  Fly   220 LQMHDMENARGSSSYTSTSSTTSSNSSSSEYTRSSRQSSSLVDIQYTESDSDIEREIRGSTDEIT 284
            | :|..:...|                   ..|:....:::|.|.:....|
Human   139 L-LHRAKKGLG-------------------MRRADVSMANMVLIGFFSCIS-------------- 169

  Fly   285 VPVTVCVFVMVGYILWGALLFGRWEDWNYLDGSYFCLISLSSIGFGDLV--PGDRVITADRDKVE 347
               |:|:         ||..|..:|.|.:....|:|.|:|::|||||.|  ..|:.:......|.
Human   170 ---TLCI---------GAAAFSHYEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVA 222

  Fly   348 VSFILCAIYLLLGMAVIAMCFNLM 371
            .||    :|:|.|:.||....||:
Human   223 FSF----VYILTGLTVIGAFLNLV 242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sand	NP_610349.1	Ion_trans_2	123..183	CDD:285168	25/59 (42%)
sand	NP_610349.1	Ion_trans_2	292..377	CDD:285168	26/82 (32%)
KCNK3	NP_002237.1	Ion_trans_2	<77..132	CDD:400301	24/86 (28%)
		Ion_trans_2	167..247	CDD:400301	29/106 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..286
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..357
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910