DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sand and KCNK2

DIOPT Version :9

Sequence 1:	NP_610349.1	Gene:	sand / 35777	FlyBaseID:	FBgn0033257	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_001017425.2	Gene:	KCNK2 / 3776	HGNCID:	6277	Length:	426	Species:	Homo sapiens

Alignment Length:	365	Identity:	88/365 - (24%)
Similarity:	146/365 - (40%)	Gaps:	123/365 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 IILLVTFYIIGGAFIFQSIEIFEYERLKSEKPHRFIARNFSGECLSRIWELTAENISFFDHHAYR 100
            |.|:|..|:|.||.:|:::          |:||.          :|:...:..:..:|...|:.
Human    65 IFLVVVLYLIIGATVFKAL----------EQPHE----------ISQRTTIVIQKQTFISQHSC- 108

  Fly   101 RRVNDVLLD---------YQRAIVKKQLKGPDVEQWSFSGAFLYSLTVITTIGYGNITPHSECGK 156
              ||...||         ....|:........:..|....:|.::.|||||||:|||:|.:|.||
Human   109 --VNSTELDELIQQIVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGK 171

  Fly   157 LVTILYAIIGMPLFLLYLSNIGDVLAKSFKWIYSKVCLCRICPGVAKRRIIRERRKMRQLARALQ 221
            :..|:||::|:|||...|:.:||.|..    |:.|        |:||
Human   172 IFCIIYALLGIPLFGFLLAGVGDQLGT----IFGK--------GIAK------------------ 206

  Fly   222 MHDMENARGSSSYTSTSSTTSSNSSSSEYTRSSRQSSSLVDIQYTESDSDIEREIRGSTDEITVP 286
                                                         ..|:.|:..:  |..:|.:
Human   207 ---------------------------------------------VEDTFIKWNV--SQTKIRI- 223

  Fly   287 VTVCVFVMVGYILWGAL---LFGRWEDWNYLDGSYFCLISLSSIGFGDLVPGDRVIT-ADRDKVE 347
            ::..:|::.|.:|:.||   :|...|.|:.||..||.:|:|::|||||.|.|...|. .|..|..
Human   224 ISTIIFILFGCVLFVALPAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPV 288

  Fly   348 VSFILCAIYLLLGMAVIAMCFNLMQEQVVHNIRAIKRGFK 387
            |.|     ::|:|:|..|...:::.:.    :|.|.:..|
Human   289 VWF-----WILVGLAYFAAVLSMIGDW----LRVISKKTK 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sand	NP_610349.1	Ion_trans_2	123..183	CDD:285168	27/59 (46%)
sand	NP_610349.1	Ion_trans_2	292..377	CDD:285168	30/88 (34%)
KCNK2	NP_001017425.2	Ion_trans_2	<142..196	CDD:400301	26/53 (49%)
		Ion_trans_2	234..312	CDD:400301	28/86 (33%)
		Required for basal channel activity. /evidence=ECO:0000250	354..426
		Essential for chloroform and halothane sensitivity. /evidence=ECO:0000250	378..426
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9913
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.910