Protein Alignment sand and KCNK1

DIOPT Version :9

• Sequence 1: NP_610349.1
• Gene: sand / 35777
• FlyBaseID: FBgn0033257
• Length: 395
• Species: Drosophila melanogaster
• Sequence 2: NP_002236.1
• Gene: KCNK1 / 3775
• HGNCID: 6272
• Length: 336
• Species: Homo sapiens
• Alignment Length: 385
• Identity: 92/385 - (23%)
• Similarity: 149/385 - (38%)
• Gaps: 142/385 - (36%)

  Fly    24 RHFTAFMFSNVGIILL-VTFYIIGGAFIFQSIEIFEYERLKSEK----PHRFIARNFSGECLS-- 81
            ||.:|:.|   |.::| ...|::.||.:|.|:|: .||.|..::    ..||:..:   ||||
Human    16 RHRSAWCF---GFLVLGYLLYLVFGAVVFSSVEL-PYEDLLRQELRKLKRRFLEEH---ECLSEQ 73

  Fly    82 -------RIWELTAENISFFDHHAYRRRVNDVLLDYQRAIVKKQLKGPDVEQWSFSGAFLYSLTV 139
                   |:.|.:...:|...:.:..                        ..|.|:.|..::.||
Human    74 QLEQFLGRVLEASNYGVSVLSNASGN------------------------WNWDFTSALFFASTV 114

  Fly   140 ITTIGYGNITPHSECGKLVTILYAIIGMPLFLLYLSNIGDVLAKSFKWIYSKVCLCRICPGVAKR 204
            ::|.|||:..|.|:.||...|:|::||:|..||:|:.:                :.||...|.:|
Human   115 LSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAV----------------VQRITVHVTRR 163

  Fly   205 RIIRERRKMRQLARALQMHDMENARGSSSYTSTSSTTSSNSSSSEYTRSSRQSSSLVDIQYTESD 269
            .:             |..|
Human   164 PV-------------LYFH---------------------------------------------- 169

  Fly   270 SDIEREIR-GSTDEITVPVTVCVFVMVGYILWG------ALLFGRWE-DWNYLDGSYFCLISLSS 326
                  || |.:.::   |.:...|::|::...      |.:|...| |||:|:..|||.||||:
Human   170 ------IRWGFSKQV---VAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLST 225

  Fly   327 IGFGDLVPGDRVITADRDKVEVSFILCAIYLLLGMAVIAMCFNLMQEQVVHNIRAIKRGF 386
            ||.||.|||:......|:..::. |.|  |||||:  |||...|.....:|.::..::.|
Human   226 IGLGDYVPGEGYNQKFRELYKIG-ITC--YLLLGL--IAMLVVLETFCELHELKKFRKMF 280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sand	NP_610349.1	Ion_trans_2	123..183	CDD:285168	21/59 (36%)
		Ion_trans_2	292..377	CDD:285168	35/91 (38%)
KCNK1	NP_002236.1	Ion_trans_2	<101..157	CDD:400301	22/71 (31%)
		pore-forming domain	107..123		7/15 (47%)
		Ion_trans_2	192..267	CDD:400301	33/79 (42%)
		pore-forming domain	212..238		15/25 (60%)
		Important for intracellular retention in recycling endosomes. /evidence=ECO:0000269|PubMed:19959478	293..299

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10857
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810