DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sand and twk-48

DIOPT Version :9

Sequence 1:	NP_610349.1	Gene:	sand / 35777	FlyBaseID:	FBgn0033257	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_001022681.1	Gene:	twk-48 / 3565640	WormBaseID:	WBGene00010784	Length:	372	Species:	Caenorhabditis elegans

Alignment Length:	408	Identity:	137/408 - (33%)
Similarity:	215/408 - (52%)	Gaps:	72/408 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RRREKPAFERFKDHCRHFTAFMFSNVGIILLVTFYIIGGAFIFQSIEIFEYERLKSEKPH----R 69
            ||..:....|..:..:...||.||::|:..||..|.:.||.||:::          |.||    :
Worm     3 RRHRRSKVTRVVNLVKKIIAFFFSHIGLCALVVGYALLGAVIFKAV----------EGPHEAEIQ 57

  Fly    70 FIARNFSGECLSRIWELTAENISFFDHHAYRRRVNDVLLDYQRAIVKKQLKGPDVE------QWS 128
            .:.::...:.:..:|..|. .::..|...:::.|.|.:..::...:....||.|.:      ||:
Worm    58 ELVKSAREKAVDVVWNATF-RVNRLDSKQWKKTVLDEVKRFKTVCMLSIRKGYDGKEYGKQAQWT 121

  Fly   129 FSGAFLYSLTVITTIGYGNITPHSECGKLVTILYAIIGMPLFLLYLSNIGDVLAKSFKWIYSKVC 193
            |:|||||||||||||||||....:..||.:|:||||||:||.||:|:|||||:||.|:::|::
Worm   122 FTGAFLYSLTVITTIGYGNTAAKTYIGKTLTMLYAIIGIPLMLLFLTNIGDVMAKIFRFLYAQ-- 184

  Fly   194 LCRICPGVAKRRII--RERRKMRQLARALQMHDMENARGSSSYTSTSSTTSSNSSSSEYTRSSR- 255
            ..|:     |.|:|  .::||..::.||                        ||..|..||..|
Worm   185 SIRL-----KFRLILWHKKRKAAKIRRA------------------------NSLVSRLTRGHRV 220

  Fly   256 QSSSLVDIQYTESDSDIE-----------REIR----GSTDEITVPVTVCVFVMVGYILWGALLF 305
            ::.|.||.....:.:|:|           .|:|    ...:.:|||:::.||.|:||:..|..:|
Worm   221 KADSSVDSFGLGAGADVEDLLTARVEMEQLEVRETAAAQLESMTVPISLVVFTMLGYLGVGTTIF 285

  Fly   306 GRWEDWNYLDGSYFCLISLSSIGFGDLVPGDRVITADRDKVEVSFILCAIYLLLGMAVIAMCFNL 370
            ..||.|.:|:..|||.|||::|||||..|...|  ::.|:.:...::.:||||.|||::||||||
Worm   286 KVWEGWTFLESFYFCFISLTTIGFGDKFPSTSV--SNTDEAQEKLVITSIYLLFGMALLAMCFNL 348

  Fly   371 MQEQVVHNIRAIKRGFKA 388
            .||:|.:..|.|...|::
Worm   349 AQEEVQNKTRWIADKFRS 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sand	NP_610349.1	Ion_trans_2	123..183	CDD:285168	40/65 (62%)
sand	NP_610349.1	Ion_trans_2	292..377	CDD:285168	40/84 (48%)
twk-48	NP_001022681.1	Ion_trans_2	<117..176	CDD:285168	39/58 (67%)
twk-48	NP_001022681.1	Ion_trans_2	272..355	CDD:285168	40/84 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I5180
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5602
OMA	1	1.010	-	-		QHG29178
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106457
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2863
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.740