DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sand and twk-29

DIOPT Version :9

Sequence 1:	NP_610349.1	Gene:	sand / 35777	FlyBaseID:	FBgn0033257	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_001021467.1	Gene:	twk-29 / 185828	WormBaseID:	WBGene00006681	Length:	476	Species:	Caenorhabditis elegans

Alignment Length:	369	Identity:	83/369 - (22%)
Similarity:	146/369 - (39%)	Gaps:	128/369 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 IILLVTFYIIGGAFIFQSIEIFEYERLKSEKPHRFIARNFSGECLSRIWELTAENISFFDHHAYR 100
            |:.|:.:..||| |||.:.| |||:        :::.:|.:.|     ..|..|::...|:....
Worm    56 IVFLIIYTTIGG-FIFLNFE-FEYQ--------QYMKQNATLE-----KRLCIESLLNRDNRLRL 105

  Fly   101 RRVNDVLLDYQRAIVKKQLKGPDVEQWSFSGAFLYSLTVITTIGYGNITPHSECGKLVTILYAII 165
            .|.:||........:.:.:| .|..||||..|.||||.::||:|||.|.|.:..|::.|::|...
Worm   106 TRASDVAAAIAERCLTENVK-DDRMQWSFKSAALYSLGILTTLGYGKIEPQTINGRISTVIYGFF 169

  Fly   166 GMPLFLLYLSNIG---DVLAKSFKWIYSKVCLCRICPGVAKRRIIRERRKMRQLARALQMHDMEN 227
            |:||.::.|:|.|   :.:|..|                  ||:|..||:...        :.||
Worm   170 GIPLTVILLTNFGRYLEAMATRF------------------RRLISCRRRRED--------EDEN 208

  Fly   228 ARGSSSYTSTSSTTSSNSSSSEYTRSSRQSSSLVDIQYTESDSDIEREIRGSTDEITVPVTVCVF 292
            ..||:.:                                                         |
Worm   209 VSGSTLF---------------------------------------------------------F 216

  Fly   293 VMVGYILWGA----LLFGRWEDWNYLDGSYFCLISLSSIGFGDLVPGDRVITADRDKVEVSFILC 353
            :::.|::.||    |:.|:::   :.:|.|:..|.|::|.:||::|.:.....          :.
Worm   217 IVLVYLILGATMIPLMSGQFD---FFNGIYYAFICLTAIEYGDIIPQNNWFLP----------IS 268

  Fly   354 AIYLLLGMAV--IAMCFNLMQEQVVH-------NIRAIKRGFKA 388
            ..|:..|:|:  ||:....:..:.:|       ||..|:..|.|
Worm   269 VFYMCTGLAISTIALDIGSIYVRKLHFIGKKIKNIANIRIWFGA 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sand	NP_610349.1	Ion_trans_2	123..183	CDD:285168	26/62 (42%)
sand	NP_610349.1	Ion_trans_2	292..377	CDD:285168	19/90 (21%)
twk-29	NP_001021467.1	Ion_trans_2	127..186	CDD:285168	26/58 (45%)
twk-29	NP_001021467.1	Ion_trans_2	216..292	CDD:285168	19/88 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020