DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sand and twk-30

DIOPT Version :9

Sequence 1:	NP_610349.1	Gene:	sand / 35777	FlyBaseID:	FBgn0033257	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_492381.3	Gene:	twk-30 / 185335	WormBaseID:	WBGene00006682	Length:	608	Species:	Caenorhabditis elegans

Alignment Length:	387	Identity:	84/387 - (21%)
Similarity:	155/387 - (40%)	Gaps:	108/387 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 FMFSNVGIILLVTFYIIGGAFIFQSIEIFEYERLKSEKPHRFIARNFSGECLSRIWELTAENISF 93
            |:..:|.:|..|..|||.||.:||.:|....:.||  |.|.......:.:.:.::|.:...
Worm     4 FLSLHVLLIGSVVLYIILGAIVFQMLEGEHLDALK--KDHMAKIEQNAKDYVDKLWSVAKR---- 62

  Fly    94 FDHHAYRRRVNDVLL-----------DY-------QRAIVKKQLKGPDVEQWSFSGAFLYSLTVI 140
             |...| :.|.|::.           ||       .||:  :.....|...|.|:.:..::.|::
Worm    63 -DRDKY-KNVEDLIKSVKEDTVDDFNDYVDTVFYAHRAV--RHGYDEDSPTWDFANSVFFTTTML 123

  Fly   141 TTIGYGNITPHSECGKLVTILYAIIGMPLFLLYLSNIGDVLAKSFKWIYSKV---CLCRICPGVA 202
            |:||||.:.|.:..|:|..::|.:||:||.|:.::|:...|:::..:::.::   ||
Worm   124 TSIGYGYVAPSTFGGRLFGVIYCLIGIPLTLVTVANVAKFLSETIFFLHYELWNKCL-------- 180

  Fly   203 KRRIIRERRKMRQLARALQMHDMENARGSSSYTSTSSTTSSNSSSSEYTRSSRQSSSLVDIQYTE 267
                                                          |:.|..:.......:|...
Worm   181 ----------------------------------------------EWKRKRKGEVEADPLQPMF 199

  Fly   268 SDSDIEREIRGSTDEITV----PVTVCVFVMVGYILWGALLFGRWEDWNYLDGSYFCLISLSSIG 328
            .|.:.|.||   .|.:.:    |:||..||.| |....|.:...||.|.|::..||..||:.::|
Worm   200 GDDENEEEI---LDRVRLVRFPPLTVFFFVFV-YGCIAAWVVRYWETWTYVESLYFIFISILTVG 260

  Fly   329 FGDL--VPGDRVITADRDKVEVSFILCAIYLLLGMAVIAMCFNLMQEQVVHNIRAIKRGFKA 388
            |||:  .||:..:|             ..::::|:.:..||.:::....:..|..:.|..|:
Worm   261 FGDIRPSPGNIWVT-------------LAFVVVGVILTTMCMDVVGRMYLKEIHYLGRKLKS 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sand	NP_610349.1	Ion_trans_2	123..183	CDD:285168	20/59 (34%)
sand	NP_610349.1	Ion_trans_2	292..377	CDD:285168	23/86 (27%)
twk-30	NP_492381.3	Ion_trans_2	103..166	CDD:285168	20/62 (32%)
		Ion_trans_2	224..298	CDD:285168	23/87 (26%)
		FN3	379..469	CDD:238020
		FN3	475..565	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820