DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sand and twk-28

DIOPT Version :9

Sequence 1:	NP_610349.1	Gene:	sand / 35777	FlyBaseID:	FBgn0033257	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_508732.3	Gene:	twk-28 / 183714	WormBaseID:	WBGene00006680	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	423	Identity:	110/423 - (26%)
Similarity:	186/423 - (43%)	Gaps:	103/423 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSRRSSFRRREKPAFERFKDHCRHFTAFMFSNVGIILLVTFYIIGGAFIFQSIEIFEYERLKSE 65
            :|...:....:||..|...|....|        ||:::|:..|:|.|||:|:.:          |
Worm    38 ISDDETEVETKEKKLFVYAKRILPH--------VGLVILLFLYLIAGAFLFRYL----------E 84

  Fly    66 KPHRFIARN--------FSGECLSRIWELTAENISFFDHHAYRRRVNDVLLDYQRAIVKKQLKG- 121
            .|.....||        ...|....||.:|.::    |:...|...|.:..:|...:||...:.
Worm    85 APKELETRNHELTTILGLRDEFQDHIWNITQDS----DNRISREAFNAINQEYFEQLVKNMFQAY 145

  Fly   122 ---------------PDVEQWSFSGAFLYSLTVITTIGYGNITPHSECGKLVTILYAIIGMPLFL 171
                           .|...|:|..:..::.||||||||||:.|.:..|::..|::|::|:||.|
Worm   146 RNQFITAKHLLNKTREDEVLWTFPNSMFFAATVITTIGYGNLVPITVTGRVACIIFALLGIPLLL 210

  Fly   172 LYLSNIGDVLAKSFKWIYSKVCLCRICPGVAKRRIIRERRKMRQLARALQMHDMENARGSSSYTS 236
            :.:::||..|::...::|      |...|. ||::.|:.:|:                 :|.|.|
Worm   211 VTIADIGKFLSEFLSYLY------RSYRGF-KRKLRRQSKKI-----------------TSQYRS 251

  Fly   237 TSSTTSSNSSSSEYTRSSRQSSSLVDIQYTESDSDIEREIRGSTDEITVPVTVCVFVMVGYILWG 301
            .|.:.||:...|    |...|.:|.||     |||.|   ..:.||:.:||.:.:.|::.|...|
Worm   252 QSQSRSSSVMGS----SKAGSMNLHDI-----DSDSE---DSAGDELRIPVFMVLLVLLAYTAIG 304

  Fly   302 ALLFGRWEDWNYLDGSYFCLISLSSIGFGDLVPGDRVITADRDKVEVSFILCAIYLLLGMAVIAM 366
            ..||..||...|.:..|||.|:::::||||:||.::|.        |.|.:.  |::.|:::..|
Worm   305 GFLFQSWEHLEYFEAFYFCFITMATVGFGDIVPNEQVY--------VFFTMA--YIIFGLSLATM 359

  Fly   367 CFNLMQEQVVHNIR-----------AIKRGFKA 388
            |.:|...:.:..|.           |:..|.:|
Worm   360 CIDLAGTEYIRKIHYLGTKMEDAKGAVMTGLQA 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sand	NP_610349.1	Ion_trans_2	123..183	CDD:285168	24/59 (41%)
sand	NP_610349.1	Ion_trans_2	292..377	CDD:285168	26/84 (31%)
twk-28	NP_508732.3	Ion_trans_2	<166..222	CDD:285168	23/55 (42%)
twk-28	NP_508732.3	Ion_trans_2	295..370	CDD:285168	26/84 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920