DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sand and kcnk18

DIOPT Version :9

Sequence 1:	NP_610349.1	Gene:	sand / 35777	FlyBaseID:	FBgn0033257	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	XP_031761959.1	Gene:	kcnk18 / 100486306	XenbaseID:	XB-GENE-6257492	Length:	429	Species:	Xenopus tropicalis

Alignment Length:	457	Identity:	118/457 - (25%)
Similarity:	190/457 - (41%)	Gaps:	127/457 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SRRSSFRRREKPAFERFKDHCRHFTAF--MFSNVGIILLVTFYIIGGAFIFQSI------EIFEY 59
            |...:|...:.|..:|.|...:...||  .|.:|.::..:..|.|.||.:|..|      ||.::
Frog    15 SEMETFTTTQGPPPQRGKCSWKCLQAFWISFPHVCLVCSLVLYSILGALMFWFIEGSREKEISQF 79

  Fly    60 ERLKSEKPHRFIARNFSGECLSRIWELTAENIS--------------FFDHHAYRRRVNDVLLDY 110
            |                 |.|.::| :..:|.|              .|...|....:.|:.:::
Frog    80 E-----------------EFLEKLW-MIVQNSSIDNATISDNGSAPEIFKELAREAIITDLQVEW 126

  Fly   111 QRAIVKKQLKGPDVEQWSFSGAFLYSLTVITTIGYGNITPHSECGKLVTILYAIIGMPLFLLYLS 175
                    |:.|: |||||..:..:..||.||:|||:|.|.:..|||..::||.:|:||.||.|:
Frog   127 --------LQKPE-EQWSFKSSLFFCCTVFTTVGYGHICPVTMYGKLACMVYATLGIPLMLLLLA 182

  Fly   176 NIGDVLAKSFKWIYSKVCLC--RICPGVAKRRIIRERRKMRQLARALQMHDMENARGSSSYTSTS 238
            ::||:||:.....|.:..|.  ::|          .:.|..:|:...:.|.     |.||...|.
Frog   183 DLGDILARLLSRTYKRAVLACNKLC----------HKPKPIKLSSLHKEHS-----GKSSLLKTM 232

  Fly   239 STTSSNSSSSEYT------------------------------------RSSRQSSSL----VDI 263
            .:..|.......|                                    :||.|..|.    :|:
Frog   233 DSRVSMKEPLNITEVIKTQASVKRKYLQMRNIDIFELIIVKENQKVLPLKSSLQQKSFSCPDLDL 297

  Fly   264 QYTESDSDIER--EIRGSTDEITVPVTVCVFVMVGYILWGALLFGRWE-DWNYLDGSYFCLISLS 325
             :..|||.::.  :|....|.:.||:.:.|.|||.||:.||.:...|| ||..:|..|||.::|:
Frog   298 -WPPSDSAMQNFDKIGEELDHLDVPIVLIVLVMVAYIMCGACILPLWEDDWTTIDAFYFCFVTLT 361

  Fly   326 SIGFGDLVPGDRVITADRDKVEVSFILCAIYLLLGMAVIAMCFNLMQEQVVHNIRAIKRGFKACF 390
            :|||||::|          |....|:|.:.|.::||.::.|.|.|.|.::|       ..:|.|.
Frog   362 TIGFGDIIP----------KHPNYFLLLSAYTVVGMVIVCMAFKLGQNRLV-------SFYKQCI 409

  Fly   391 RC 392
            .|
Frog   410 LC 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sand	NP_610349.1	Ion_trans_2	123..183	CDD:285168	28/59 (47%)
sand	NP_610349.1	Ion_trans_2	292..377	CDD:285168	32/85 (38%)
kcnk18	XP_031761959.1	Ion_trans_2	<131..>175	CDD:400301	20/44 (45%)
kcnk18	XP_031761959.1	Ion_trans_2	327..402	CDD:400301	32/84 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2863
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110