DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sut1 and HXT4

DIOPT Version :9

Sequence 1:	NP_523658.1	Gene:	sut1 / 35774	FlyBaseID:	FBgn0028563	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_011960.2	Gene:	HXT4 / 856492	SGDID:	S000001134	Length:	576	Species:	Saccharomyces cerevisiae

Alignment Length:	552	Identity:	129/552 - (23%)
Similarity:	224/552 - (40%)	Gaps:	78/552 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ATKSQPAEAQQLYPQPNRVELLSAQTDPSQKPRWGNL--------------------------LL 40
            |.::.||:|.    .|...:..||.:.||.|....::                          :.
Yeast    12 AVQNTPADAL----SPVESDSNSALSTPSNKAERDDMKDFDENHEESNNYVEIPKKPASAYVTVS 72

  Fly    41 LVALATTFGGAV---STGYCIGVINAPSKLMKVWCNQTLHD-TYGSNLSAGGLDLLWSCVVSVFL 101
            :..|...|||.|   .||...|.:.....:.:.....  || ||..:....||      :||:|.
Yeast    73 ICCLMVAFGGFVFGWDTGTISGFVAQTDFIRRFGMKH--HDGTYYLSKVRTGL------IVSIFN 129

  Fly   102 VGGAIGSLGGAGAANKFGRKACFLICGALFTVGAVLFFFCRAASSVE---MLVIGRFVVGLASGL 163
            :|.|||.:..|...:.:|||...::...::.:|.::     ..:|:.   ...|||.:.||..|.
Yeast   130 IGCAIGGIILAKLGDMYGRKMGLIVVVVIYIIGIII-----QIASINKWYQYFIGRIISGLGVGG 189

  Fly   164 VTATLPMYLSEVAPMALRGTLGVFIAVGVTGGVVVGQVCSLANVFGTEDL-----WHYALTAYMF 223
            :....||.:|||:|..:||||.....:.:|.|:.:|...:    :||:..     |...|.....
Yeast   190 IAVLSPMLISEVSPKHIRGTLVSCYQLMITLGIFLGYCTN----YGTKTYTNSVQWRVPLGLGFA 250

  Fly   224 LILVCYLPSYLFPESPKFLYIVKGNRAAAKREL---QRLRGKDAEELIAQEMAEMEAESNAKVQT 285
            ..|.........||||::|..| |....|||.:   .::...|...:...|:.:...|:......
Yeast   251 WALFMIGGMTFVPESPRYLVEV-GKIEEAKRSIALSNKVSADDPAVMAEVEVVQATVEAEKLAGN 314

  Fly   286 SSFCDVL-RDPRLTLPLIIVCCFHGGQQLSGINAIFYYSVSIFEKAGLSTVDAQWANLGAGCLNL 349
            :|:.::. ...::...||:.......|||:|.|..|||..::|...||.  |:...::..|.:|.
Yeast   315 ASWGEIFSTKTKVFQRLIMGAMIQSLQQLTGDNYFFYYGTTVFTAVGLE--DSFETSIVLGIVNF 377

  Fly   350 AVSLLGPWLMAKCNRRTLMMFSCA---LCSVFLFTIAFVLFY----IDQVSWFAIACIV---CIM 404
            |.:.:|.:|:.:..||..:::..|   .|.|...::.....:    .:..|..|..|::   |.
Yeast   378 ASTFVGIFLVERYGRRRCLLWGAASMTACMVVFASVGVTRLWPNGKKNGSSKGAGNCMIVFTCF- 441

  Fly   405 GYIFFYQFGLGPIPYFIGAELFEVAPRSVAMSMGSLASWTCNFIIGISFPLLQNAWGAFVFLPFS 469
             |:|.:.....|||:.:.:|.|.:..:|..|::....:|...|:||...|.:..|...:....|.
Yeast   442 -YLFCFATTWAPIPFVVNSETFPLRVKSKCMAIAQACNWIWGFLIGFFTPFISGAIDFYYGYVFM 505

  Fly   470 ITCVLLFLLTKFYLPETRGRDPSEVAPLVSKG 501
            ...|..:....|::|||:|....||..|..:|
Yeast   506 GCLVFSYFYVFFFVPETKGLTLEEVNTLWEEG 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut1	NP_523658.1	Sugar_tr	55..497	CDD:278511	111/464 (24%)
sut1	NP_523658.1	MFS	96..482	CDD:119392	96/407 (24%)
HXT4	NP_011960.2	Sugar_tr	74..534	CDD:395036	117/481 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342881
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2115
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13429
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.880